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Search Results for all work with filters:

  • Engineering, Environmental

Work 1-10 of 44

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Article

Process evaluation and assessment of use of a large scale water filter and cookstove program in Rwanda

by Christina K. Barstow; Corey L. Nagel; Thomas Clasen; Evan A. Thomas

2016

Subjects
  • Engineering, Environmental
  • Health Sciences, Public Health
  • File Download
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Abstract:Close

Background: In an effort to reduce the disease burden in rural Rwanda, decrease poverty associated with expenditures for fuel, and minimize the environmental impact on forests and greenhouse gases from inefficient combustion of biomass, the Rwanda Ministry of Health (MOH) partnered with DelAgua Health (DelAgua), a private social enterprise, to distribute and promote the use of improved cookstoves and advanced water filters to the poorest quarter of households (Ubudehe 1 and 2) nationally, beginning in Western Province under a program branded Tubeho Neza (“Live Well”). The project is privately financed and earns revenue from carbon credits under the United Nations Clean Development Mechanism. Methods: During a 3-month period in late 2014, over 470,000 people living in over 101,000 households were provided free water filters and cookstoves. Following the distribution, community health workers visited nearly 98% of households to perform household level education and training activities. Over 87 % of households were visited again within 6 months with a basic survey conducted. Detailed adoption surveys were conducted among a sample of households, 1000 in the first round, 187 in the second. Results: Approximately a year after distribution, reported water filter use was above 90 % (+/−4 % CI) and water present in filter was observed in over 76 % (+/−6 % CI) of households, while the reported primary stove was nearly 90 % (+/−4.4 % CI) and of households cooking at the time of the visit, over 83 % (+/−5.3 % CI) were on the improved stove. There was no observed association between household size and stove stacking behavior. Conclusions: This program suggests that free distribution is not a determinant of low adoption. It is plausible that continued engagement in households, enabled by Ministry of Health support and carbon financed revenue, contributed to high adoption rates. Overall, the program was able to demonstrate a privately financed, public health intervention can achieve high levels of initial adoption and usage of household level water filtration and improved cookstoves at a large scale.

Article

Quantifying the Adaptive Cycle

by David G. Angeler; Craig R. Allen; Ahjond S. Garmestani; Lance Gunderson; Olle Hjerne; Monika Winder

2015

Subjects
  • Environmental Sciences
  • Engineering, Environmental
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Abstract:Close

The adaptive cycle was proposed as a conceptual model to portray patterns of change in complex systems. Despite the model having potential for elucidating change across systems, it has been used mainly as a metaphor, describing system dynamics qualitatively. We use a quantitative approach for testing premises (reorganisation, conservatism, adaptation) in the adaptive cycle, using Baltic Sea phytoplankton communities as an example of such complex system dynamics. Phytoplankton organizes in recurring spring and summer blooms, a well-established paradigm in planktology and succession theory, with characteristic temporal trajectories during blooms that may be consistent with adaptive cycle phases. We used long-term (1994–2011) data and multivariate analysis of community structure to assess key components of the adaptive cycle. Specifically, we tested predictions about: reorganisation: spring and summer blooms comprise distinct community states; conservatism: community trajectories during individual adaptive cycles are conservative; and adaptation: phytoplankton species during blooms change in the long term. All predictions were supported by our analyses. Results suggest that traditional ecological paradigms such as phytoplankton successional models have potential for moving the adaptive cycle from a metaphor to a framework that can improve our understanding how complex systems organize and reorganize following collapse. Quantifying reorganization, conservatism and adaptation provides opportunities to cope with the intricacies and uncertainties associated with fast ecological change, driven by shifting system controls. Ultimately, combining traditional ecological paradigms with heuristics of complex system dynamics using quantitative approaches may help refine ecological theory and improve our understanding of the resilience of ecosystems.

Article

Effects of Single and Combined Water, Sanitation and Handwashing Interventions on Fecal Contamination in the Domestic Environment: A Cluster-Randomized Controlled Trial in Rural Bangladesh

by Ayse Ercumen; Andrew Mertens; Benjamin F. Arnold; Jade Benjamin-Chung; Alan E. Hubbard; Mir Alvee Ahmed; Mir Himayet Kabir; Md. Masudur Rahman Khalil; Ashish Kumar; Md. Sajjadur Rahman; Sarker Masud Parvez; Leanne Unicomb; Mahbubur Rahman; Pavani K. Ram; Thomas Clasen; Stephen P. Luby; John M. Colford Jr.

2018

Subjects
  • Environmental Sciences
  • Engineering, Environmental
  • Health Sciences, Public Health
  • File Download
  • View Abstract

Abstract:Close

Water, sanitation, and hygiene interventions have varying effectiveness in reducing fecal contamination in the domestic environment; delivering them in combination could yield synergies. We conducted environmental assessments within a randomized controlled trial in Bangladesh that implemented single and combined water treatment, sanitation, handwashing (WSH) and nutrition interventions (WASH Benefits, NCT01590095). After one and two years of intervention, we quantified fecal indicator bacteria in samples of drinking water (from source or storage), child hands, children's food and sentinel objects. In households receiving single water treatment interventions, Escherichia coli prevalence in stored drinking water was reduced by 50% and concentration by 1-log. E. coli prevalence in food was reduced by 30% and concentration by 0.5-log in households receiving single water treatment and handwashing interventions. Combined WSH did not reduce fecal contamination more effectively than its components. Interventions did not reduce E. coli in groundwater, on child hands and on objects. These findings suggest that WSH improvements reduced contamination along the direct transmission pathways of stored water and food but not along indirect upstream pathways. Our findings support implementing water treatment and handwashing to reduce fecal exposure through water and food but provide no evidence that combining interventions further reduces exposure.

Article

The roles of water, sanitation and hygiene in reducing schistosomiasis: a review

by Jack E.T. Grimes; David Croll; Wendy E. Harrison; Jurg Utzinger; Matthew Freeman; Michael R. Templeton

2015

Subjects
  • Engineering, Environmental
  • Health Sciences, Public Health
  • File Download
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Abstract:Close

Schistosomiasis is a disease caused by infection with blood flukes of the genus Schistosoma. Transmission of, and exposure to, the parasite result from faecal or urinary contamination of freshwater containing intermediate host snails, and dermal contact with the same water. The World Health Assembly resolution 65.21 from May 2012 urges member states to eliminate schistosomiasis through preventive chemotherapy (i.e. periodic large-scale administration of the antischistosomal drug praziquantel to school-aged children and other high-risk groups), provision of water, sanitation and hygiene (WASH) and snail control. However, control measures focus almost exclusively on preventive chemotherapy, while only few studies made an attempt to determine the impact of upgraded access to safe water, adequate sanitation and good hygiene on schistosome transmission. We recently completed a systematic review and meta-analysis pertaining to WASH and schistosomiasis and found that people with safe water and adequate sanitation have significantly lower odds of a Schistosoma infection. Importantly though, the transmission of schistosomiasis is deeply entrenched in social-ecological systems, and hence is governed by setting-specific cultural and environmental factors that determine human behaviour and snail populations. Here, we provide a comprehensive review of the literature, which explores the transmission routes of schistosomes, particularly focussing on how these might be disrupted with WASH-related technologies and human behaviour. Additionally, future research directions in this area are highlighted.

Article

Characterizing the spatial distribution of multiple pollutants and populations at risk in Atlanta, Georgia

by John L. Pearce; Lance Waller; Stefanie Sarnat; Howard Chang; Mitchel Klein; James A. Mulholland; Paige Tolbert

2016

Subjects
  • Health Sciences, Public Health
  • Environmental Sciences
  • Engineering, Environmental
  • File Download
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Abstract:Close

Background: Development of exposure metrics that identify contrasts in multipollutant air quality across space are needed to better understand multipollutant geographies and health effects from air pollution. Objective: Our aim is to improve understanding of: 1) long-term spatial distributions of multiple pollutants across urban environments; and 2) demographic characteristics of populations residing within areas that experience differing long-term air quality in order to assist in the development of future epidemiologic studies. Methods: Data available for this study included seven years of spatiotemporally resolved concentrations for ten ambient air pollutants across the Atlanta metropolitan area. To analyze, we first distinguish the long-term behavior of air pollution at each grid location (n=253) by calculating study period means for each pollutant (n=10). Then, we apply the self-organizing map (SOM) technique to derive patterns in the multipollutant combinations observed among grid cells, i.e., multipollutant spatial types (MSTs), project results onto an ‘organized map’, and classify each grid cell under its most similar MST. Finally, we geographically map grid cell classifications to delineate regions of similar multipollutant characteristics and characterize associated population demographics using geographic information systems. Results: We found six MSTs well describe the nature of multipollutant combinations experienced at locations in our study area. MST profiles highlighted a range of combinations, from locations experiencing generally clean air quality (all pollutants low) to locations experiencing conditions that were relatively dirty (high long-term concentrations of several pollutants). Mapping the spatial distribution of MSTs revealed strong within-class contiguity and highlighted that downtown areas were dominated by primary pollution and that suburban areas experienced relatively higher levels of secondary pollution. Demographics show that the largest proportion of the overall population of metro Atlanta resided in downtown locations experiencing relatively high levels of primary pollution. Moreover, higher proportions of nonwhites and children in poverty reside in these areas when compared to populations that resided in suburban areas exhibiting relatively lower pollution, moderate secondary pollution, or relatively high SO2. Conclusion: Placing multipollutant air quality within a geographic regionalization problem reveals the nature and spatial distribution of differential pollutant combinations across urban environments and provides helpful insights for identifying spatial exposure and demographic contrasts for future health studies.

Article

Planning for climate change: The need for mechanistic systems-based approaches to study climate change impacts on diarrheal diseases

by Jonathan E. Mellor; Karen Levy; Julie Zimmerman; Mark Elliott; Jamie Bartram; Elizabeth Carlton; Thomas Clasen; Rebecca Dillingham; Joseph Eisenberg; Richard Guerrant; Daniele Lantagne; James Mihelcic; Kara Nelson

2016

Subjects
  • Health Sciences, Public Health
  • Environmental Sciences
  • Engineering, Environmental
  • File Download
  • View Abstract

Abstract:Close

Increased precipitation and temperature variability as well as extreme events related to climate change are predicted to affect the availability and quality of water globally. Already heavily burdened with diarrheal diseases due to poor access to water, sanitation and hygiene facilities, communities throughout the developing world lack the adaptive capacity to sufficiently respond to the additional adversity caused by climate change. Studies suggest that diarrhea rates are positively correlated with increased temperature, and show a complex relationship with precipitation. Although climate change will likely increase rates of diarrheal diseases on average, there is a poor mechanistic understanding of the underlying disease transmission processes and substantial uncertainty surrounding current estimates. This makes it difficult to recommend appropriate adaptation strategies. We review the relevant climate-related mechanisms behind transmission of diarrheal disease pathogens and argue that systems-based mechanistic approaches incorporating human, engineered and environmental components are urgently needed. We then review successful systems-based approaches used in other environmental health fields and detail one modeling framework to predict climate change impacts on diarrheal diseases and design adaptation strategies.

Article

Exposure to Mobile Source Air Pollution in Early-life and Childhood Asthma Incidence: The Kaiser Air Pollution and Pediatric Asthma Study

by Audrey Flak Pennington; Matthew Strickland; Mitchel Klein; Xinxin Zhai; Josephine T. Bates; Carolyn Drews-Botsch; Craig Hansen; Armistead G. Russell; Paige Tolbert; Lyndsey Darrow

2018

Subjects
  • Health Sciences, Public Health
  • Health Sciences, Epidemiology
  • Engineering, Environmental
  • File Download
  • View Abstract

Abstract:Close

Background: Early-life exposure to traffic-related air pollution exacerbates childhood asthma, but it is unclear what role it plays in asthma development. Methods: The association between exposure to primary mobile source pollutants during pregnancy and during infancy and asthma incidence by ages 2 through 6 was examined in the Kaiser Air Pollution and Pediatric Asthma Study, a racially diverse birth cohort of 24,608 children born between 2000 and 2010 and insured by Kaiser Permanente Georgia. We estimated concentrations of mobile source fine particulate matter (PM2.5, μg/m3), nitrogen oxides (NOX, ppb), and carbon monoxide (CO, ppm) at the maternal and child residence using a Research LINE source dispersion model for near-surface releases. Asthma was defined using diagnoses and medication dispensings from medical records. We used binomial generalized linear regression to model the impact of exposure continuously and by quintiles on asthma risk. Results: Controlling for covariates and modeling log-transformed exposure, a 2.7-fold increase in first year of life PM2.5 was associated with an absolute 4.1% (95% confidence interval, 1.6%, 6.6%) increase in risk of asthma by age 5. Quintile analysis showed an increase in risk from the first to second quintile, but similar risk across quintiles 2-5. Risk differences increased with follow-up age. Results were similar for NOX and CO and for exposure during pregnancy and the first year of life owing to high correlation. Conclusions: Results provide limited evidence for an association of early-life mobile source air pollution with childhood asthma incidence with a steeper concentration-response relationship observed at lower levels of exposure.

Article

Stability of influenza vaccine coated onto microneedles

by Hyo-Jick Choi; Dae-Goon Yoo; Brian J. Bondy; Fu-Shi Quan; Richard W Compans; Sang-Moo Kang; Mark R. Prausnitz

2012

Subjects
  • Health Sciences, Immunology
  • Engineering, Environmental
  • Biology, Zoology
  • File Download
  • View Abstract

Abstract:Close

A microneedle patch coated with vaccine simplifies vaccination by using a patch-based delivery method and targets vaccination to the skin for superior immunogenicity compared to intramuscular injection. Previous studies of microneedles have demonstrated effective vaccination using freshly prepared microneedles, but the issue of long-term vaccine stability has received only limited attention. Here, we studied the long-term stability of microneedles coated with whole inactivated influenza vaccine guided by the hypothesis that crystallization and phase separation of the microneedle coating matrix damages influenza vaccine coated onto microneedles. In vitro studies showed that the vaccine lost stability as measured by hemagglutination activity in proportion to the degree of coating matrix crystallization and phase separation. Transmission electron microscopy similarly showed damaged morphology of the inactivated virus vaccine associated with crystallization. In vivo assessment of immune response and protective efficacy in mice further showed reduced vaccine immunogenicity after influenza vaccination using microneedles with crystallized or phase-separated coatings. This work shows that crystallization and phase separation of the dried coating matrix are important factors affecting long-term stability of influenza vaccine-coated microneedles.

Article

Development of Outcome-based, Multipollutant Mobile Source Indicators

by Jorge E. Pachon; Sivaraman Balachandran; Yongtao Hu; James A. Mulholland; Lyndsey Darrow; Jeremy Sarnat; Paige Tolbert; Armistead G. Russell

2012

Subjects
  • Health Sciences, Public Health
  • Engineering, Environmental
  • Physics, Atmospheric Science
  • File Download
  • View Abstract

Abstract:Close

Multipollutant indicators of mobile source impacts are developed from readily available CO, NOx, and elemental carbon (EC) data for use in air quality and epidemiologic analysis. Two types of outcome-based Integrated Mobile Source Indicators (IMSI) are assessed. The first is derived from analysis of emissions of EC, CO, and NOxsuch that pollutant concentrations are mixed and weighted based on emission ratios for both gasoline and diesel vehicles. The emission-based indicators (IMSIEB) capture the impact of mobile sources on air quality estimated from receptor models and their uncertainty is comparable to measurement and source apportionment uncertainties. The IMSIEBhave larger correlation between two different receptor sites impacted by traffic than single pollutants, suggesting they are better indicators of the local impact of mobile sources. A sensitivity analysis of fractions of pollutants in a two-pollutant mixture and the inclusion in an epidemiologic model is conducted to develop a second set of indicators based on health outcomes. The health-based indicators (IMSIHB) are weighted combinations of CO, NOx, and EC pairs that have the lowest P value in their association with cardiovascular disease emergency department visits, possibly due to their better spatial representativeness. These outcome-based, multipollutant indicators can provide support for the setting of multipollutant air quality standards and other air quality management activities. Implications: Integrated mobile source indicators (IMSI) were developed and assessed for use in air quality and epidemiologic analysis. IMSI contribute to fill the gap in the path towards a multipollutant air quality approach in two aspects: IMSI represent an innovative way to identify mixtures of pollutants based on outcomes and constitutes an alternative approach to assess multipollutant health effects. IMSI developed for mobile sources can be easily applied to other sources. Results can support the setting of multipollutant air quality standards. Supplemental Material: Supplemental materials are available for this article. Go to the publisher's online edition of the Journal of the Air & Waste Management Association for materials showing the estimation of uncertainties using propagation of errors, comparison of source impacts from CMB and PMF and wind direction and speed for the Jefferson Street monitoring location in Atlanta.

Article

Association of Low-Moderate Arsenic Exposure and Arsenic Metabolism with Incident Diabetes and Insulin Resistance in the Strong Heart Family Study.

by Maria Grau-Perez; Chin-Chi Kuo; Matthew Gribble; Poojitha Balakrishnan; Miranda Jones Spratlen; Dhananjay Vaidya; Kevin A. Francesconi; Walter Goessler; Eliseo Guallar; Ellen K. Silbergeld; Jason G. Umans; Lyle G. Best; Elisa T. Lee; Barbara V. Howard; Shelley A. Cole; Ana Navas-Acien

2017

Subjects
  • Environmental Sciences
  • Engineering, Environmental
  • Health Sciences, Epidemiology
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BACKGROUND: High arsenic exposure has been related to diabetes, but at low-moderate levels the evidence is mixed. Arsenic metabolism, which is partly genetically controlled and may rely on certain B vitamins, plays a role in arsenic toxicity. OBJECTIVE: We evaluated the prospective association of arsenic exposure and metabolism with type 2 diabetes and insulin resistance. METHODS: We included 1,838 American Indian men and women free of diabetes (median age, 36 y). Arsenic exposure was assessed as the sum of inorganic arsenic (iAs), monomethylarsonate (MMA), and dimethylarsinate (DMA) urine concentrations (ΣAs). Arsenic metabolism was evaluated by the proportions of iAs, MMA, and DMA over their sum (iAs%, MMA%, and DMA%). Homeostasis model assessment for insulin resistance (HOMA2-IR) was measured at baseline and follow-up visits. Incident diabetes was evaluated at follow-up. RESULTS: Median ΣAs, iAs%, MMA%, and DMA% was 4.4 μg/g creatinine, 9.5%, 14.4%, and 75.6%, respectively. Over 10,327 person-years of follow-up, 252 participants developed diabetes. Median HOMA2-IR at baseline was 1.5. The fully adjusted hazard ratio [95% confidence interval (CI)] for incident diabetes per an interquartile range increase in ΣAs was 1.57 (95% CI: 1.18, 2.08) in participants without prediabetes at baseline. Arsenic metabolism was not associated with incident diabetes. ΣAs was positively associated with HOMA2-IR at baseline but negatively with HOMA2-IR at follow-up. Increased MMA% was associated with lower HOMA2-IR when either iAs% or DMA% decreased. The association of arsenic metabolism with HOMA2-IR differed by B-vitamin intake and AS3MT genetics variants. CONCLUSIONS: Among participants without baseline prediabetes, arsenic exposure was associated with incident diabetes. Low MMA% was cross-sectional and prospectively associated with higher HOMA2-IR. Research is needed to confirm possible interactions of arsenic metabolism with B vitamins and AS3MT variants on diabetes risk.
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