Skip to navigation Skip to content
  • Woodruff
  • Business
  • Health Sciences
  • Law
  • MARBL
  • Oxford College
  • Theology
  • Schools
    • Undergraduate

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing

      Community

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing
    • Graduate

      • Business School
      • Graduate School
      • School of Law
      • School of Medicine
      • School of Nursing
      • School of Public Health
      • School of Theology
  • Libraries
    • Libraries

      • Robert W. Woodruff
      • Business
      • Chemistry
      • Health Sciences
      • Law
      • MARBL
      • Music & Media
      • Oxford College
      • Theology
    • Library Tools

      • Course Reserves
      • Databases
      • Digital Scholarship (ECDS)
      • discoverE
      • eJournals
      • Electronic Dissertations
      • EmoryFindingAids
      • EUCLID
      • ILLiad
      • OpenEmory
      • Research Guides
  • Resources
    • Resources

      • Administrative Offices
      • Emory Healthcare
      • Academic Calendars
      • Bookstore
      • Campus Maps
      • Shuttles and Parking
      • Athletics: Emory Eagles
      • Arts at Emory
      • Michael C. Carlos Museum
      • Emory News Center
      • Emory Report
    • Resources

      • Emergency Contacts
      • Information Technology (IT)
      • Outlook Web Access
      • Office 365
      • Blackboard
      • OPUS
      • PeopleSoft Financials: Compass
      • Careers
      • Human Resources
      • Emory Alumni Association
  • Browse
    • Works by Author
    • Works by Journal
    • Works by Subject
    • Works by Dept
    • Faculty by Dept
  • For Authors
    • How to Submit
    • Deposit Advice
    • Author Rights
    • Publishing Your Data
    • FAQ
    • Emory Open Access Policy
    • Open Access Fund
  • About OpenEmory
    • About OpenEmory
    • About Us
    • Citing Articles
    • Contact Us
    • Privacy Policy
    • Terms of Use
 
Contact Us

Filter Results:

Year

  • 2012 (1)
  • 2013 (1)
  • 2016 (1)

Author

  • Aguilar, David (1)
  • Ampleford, Elizabeth J. (1)
  • Avila, Pedro C. (1)
  • Barnes, Kathleen C. (1)
  • Bernard, Gordon (1)
  • Bis, Joshua C. (1)
  • Bleecker, Eugene R. (1)
  • Boerwinkle, Eric (1)
  • Boyer, Laurie A. (1)
  • Brandimarto, Jeffrey (1)
  • Brown, Arleen (1)
  • Buckley, Brendan M. (1)
  • Burchard, Esteban G. (1)
  • Busse, William W. (1)
  • Butler, Javed (1)
  • Cappola, Thomas P. (1)
  • Capurso, Daniel (1)
  • Castro, Mario (1)
  • Cox, Nancy J. (1)
  • Cupples, L. Adrienne (1)
  • Dehghan, Abbas (1)
  • Demissie, Serkalem (1)
  • Djousse, Luc (1)
  • Dottin, Robert P. (1)
  • Dubinett, Steven M. (1)
  • Eng, Celeste (1)
  • Erzurum, Serpil C. (1)
  • Fair, Alecia (1)
  • Felix, Janine F. (1)
  • Fitzpatrick, Anne M (1)
  • Ford, Ian (1)
  • Ford, Jean G. (1)
  • Franco, Oscar H. (1)
  • Gaston, Benjamin (1)
  • Gaziano, J. Michael (1)
  • Gidlöf, Olof (1)
  • Gignoux, Christopher R. (1)
  • Hofman, Albert (1)
  • Howard, Timothy D. (1)
  • Hu, Donglei (1)
  • Imperato-McGinley, Julianne (1)
  • Israel, Elliot (1)
  • Jarjour, Nizar N. (1)
  • Joehanes, Roby (1)
  • Jukema, J. Wouter (1)
  • Kalogeropoulos, Andreas (1)
  • Kellis, Manolis (1)
  • Kritchevsky, Stephen B. (1)
  • Levy, Daniel (1)
  • Li, Xingnan (1)
  • Ligthart, Symen (1)
  • Liu, Chunyu (1)
  • Liu, Yongmei (1)
  • Margulies, Kenneth B. (1)
  • Mathias, Rasika A. (1)
  • Mellman, Thomas A. (1)
  • Mendelson, Michael (1)
  • Meyers, Deborah A. (1)
  • Moore, Wendy (1)
  • Moravec, Christine S. (1)
  • Morley, Michael (1)
  • Morrison, Alanna C. (1)
  • Newton-Cheh, Christopher (1)
  • Ngwa, Julius (1)
  • Nicolae, Dan L. (1)
  • Norris, Keith (1)
  • Ober, Carole (1)
  • Ofili, Elizabeth O. (1)
  • Olde, Björn (1)
  • Poland, Russell (1)
  • Psaty, Bruce M. (1)
  • Pulley, Jill (1)
  • Rice, Kenneth M. (1)
  • Rodriguez-Cintron, William (1)
  • Rodriguez-Santana, Jose R. (1)
  • Sesso, Howard D. (1)
  • Shan, Xiaoyin (1)
  • Sjögren, Marketa (1)
  • Smith, J. Gustav (1)
  • Smith, Nicholas L. (1)
  • Sotoodehnia, Nona (1)
  • Stephens, David (1)
  • Stott, David J. (1)
  • Stricker, Bruno H.Ch. (1)
  • Taylor, Kent D. (1)
  • Teague, W. Gerald (1)
  • Torgerson, Dara (1)
  • Trompet, Stella (1)
  • Uitterlinden, André G. (1)
  • Vasan, Ramachandran S. (1)
  • Verbalis, Joseph G. (1)
  • Wang, Xinchen (1)
  • Wang, Ying A. (1)
  • Wenzel, Sally E. (1)
  • West, Andrew (1)
  • Wilk, Jemma B. (1)
  • Yao, Chen (1)
  • consortium, CHARGE-QRS (1)
  • consortium, CHARGE-SCD (1)
  • consortium, EchoGen (1)

Subject

  • Health Sciences, Epidemiology (2)
  • Biology, Genetics (1)
  • Health Sciences, Immunology (1)
  • Health Sciences, Medicine and Surgery (1)

Journal

  • Clinical and Translational Science (1)
  • Journal of Allergy and Clinical Immunology (1)
  • PLoS Genetics (1)

Keyword

  • african (3)
  • biomedicin (3)
  • life (3)
  • research (3)
  • scienc (3)
  • technolog (3)
  • american (2)
  • ancestri (2)
  • associ (2)
  • genom (2)
  • genomewid (2)
  • popul (2)
  • risk (2)
  • studi (2)
  • variant (2)
  • wide (2)
  • admix (1)
  • admixtur (1)
  • africanamerican (1)
  • age (1)
  • allergi (1)
  • asthma (1)
  • blood (1)
  • cardiolog (1)
  • charg (1)
  • chromosom (1)
  • compon (1)
  • death (1)
  • dispar (1)
  • dna (1)
  • eject (1)
  • epidemiolog (1)
  • experiment (1)
  • express (1)
  • failur (1)
  • fraction (1)
  • gene (1)
  • geneticvari (1)
  • health (1)
  • heart (1)
  • hered (1)
  • herit (1)
  • human (1)
  • humanpopul (1)
  • immunolog (1)
  • institut (1)
  • loci (1)
  • locus (1)
  • map (1)
  • medicin (1)
  • metaanalysi (1)
  • methyl (1)
  • minor (1)
  • mortal (1)
  • obes (1)
  • partnership (1)
  • phenotyp (1)
  • preserv (1)
  • program (1)
  • puerto (1)
  • rate (1)
  • researchprogram (1)
  • rican (1)
  • scale (1)
  • serv (1)
  • stratif (1)
  • structur (1)
  • surviv (1)
  • test (1)
  • translat (1)

Author department

  • Academic Advancement (1)
  • Medicine: Admin (1)
  • Medicine: Cardiology (1)
  • Peds: Pulmonology (1)

Search Results for all work with filters:

  • Health Sciences, General
  • t
  • genet
  • consortium

Work 1-3 of 3

Sorted by relevance

Article

Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

by J. Gustav Smith; Janine F. Felix; Alanna C. Morrison; Andreas Kalogeropoulos; Stella Trompet; Jemma B. Wilk; Olof Gidlöf; Xinchen Wang; Michael Morley; Michael Mendelson; Roby Joehanes; Symen Ligthart; Xiaoyin Shan; Joshua C. Bis; Ying A. Wang; Marketa Sjögren; Julius Ngwa; Jeffrey Brandimarto; David J. Stott; David Aguilar; Kenneth M. Rice; Howard D. Sesso; Serkalem Demissie; Brendan M. Buckley; Kent D. Taylor; Ian Ford; Chen Yao; Chunyu Liu; CHARGE-SCD consortium; EchoGen consortium; QT-IGC consortium; CHARGE-QRS consortium; Nona Sotoodehnia; Pim van der Harst; Bruno H.Ch. Stricker; Stephen B. Kritchevsky; Yongmei Liu; J. Michael Gaziano; Albert Hofman; Christine S. Moravec; André G. Uitterlinden; Manolis Kellis; Joyce B. van Meurs; Kenneth B. Margulies; Abbas Dehghan; Daniel Levy; Björn Olde; Bruce M. Psaty; L. Adrienne Cupples; J. Wouter Jukema; Luc Djousse; Oscar H. Franco; Eric Boerwinkle; Laurie A. Boyer; Christopher Newton-Cheh; Javed Butler; Ramachandran S. Vasan; Thomas P. Cappola; Nicholas L. Smith

2016

Subjects
  • Biology, Genetics
  • Health Sciences, Epidemiology
  • Health Sciences, General
  • File Download
  • View Abstract

Abstract:Close

Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients with new-onset heart failure, we performed a meta-analysis of genome-wide association studies and follow-up genotyping in independent populations. We identified and replicated an association for a genetic variant on chromosome 5q22 with 36% increased risk of death in subjects with heart failure (rs9885413, P = 2.7x10-9). We provide evidence from reporter gene assays, computational predictions and epigenomic marks that this polymorphism increases activity of an enhancer region active in multiple human tissues. The polymorphism was further reproducibly associated with a DNA methylation signature in whole blood (P = 4.5x10-40) that also associated with allergic sensitization and expression in blood of the cytokine TSLP (P = 1.1x10-4). Knockdown of the transcription factor predicted to bind the enhancer region (NHLH1) in a human cell line (HEK293) expressing NHLH1 resulted in lower TSLP expression. In addition, we observed evidence of recent positive selection acting on the risk allele in populations of African descent. Our findings provide novel genetic leads to factors that influence mortality in patients with heart failure.

Article

Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects

by Dara Torgerson; Daniel Capurso; Elizabeth J. Ampleford; Xingnan Li; Wendy Moore; Christopher R. Gignoux; Donglei Hu; Celeste Eng; Rasika A. Mathias; William W. Busse; Mario Castro; Serpil C. Erzurum; Anne M Fitzpatrick; Benjamin Gaston; Elliot Israel; Nizar N. Jarjour; W. Gerald Teague; Sally E. Wenzel; Jose R. Rodriguez-Santana; William Rodriguez-Cintron; Pedro C. Avila; Jean G. Ford; Kathleen C. Barnes; Esteban G. Burchard; Timothy D. Howard; Eugene R. Bleecker; Deborah A. Meyers; Nancy J. Cox; Carole Ober; Dan L. Nicolae

2012

Subjects
  • Health Sciences, Immunology
  • Health Sciences, Epidemiology
  • Health Sciences, General
  • File Download
  • View Abstract

Abstract:Close

Genetic variants that contribute to asthma susceptibility might be present at varying frequencies in different populations, which is an important consideration and advantage for performing genetic association studies in admixed populations. Objective: We sought to identify asthma-associated loci in African American subjects. Methods: We compared local African and European ancestry estimated from dense single nucleotide polymorphism genotype data in African American adults with asthma and nonasthmatic control subjects. Allelic tests of association were performed within the candidate regions identified, correcting for local European admixture. Results: We identified a significant ancestry association peak on chromosome 6q. Allelic tests for association within this region identified a single nucleotide polymorphism (rs1361549) on 6q14.1 that was associated with asthma exclusively in African American subjects with local European admixture (odds ratio, 2.2). The risk allele is common in Europe (42% in the HapMap population of Utah residents with Northern and Western European ancestry from the Centre d'Etude du Polymorphisme Humain collection) but absent in West Africa (0% in the HapMap population of Yorubans in Ibadan, Nigeria), suggesting the allele is present in African American subjects because of recent European admixture. We replicated our findings in Puerto Rican subjects and similarly found that the signal of association is largely specific to subjects who are heterozygous for African and non-African ancestry at 6q14.1. However, we found no evidence for association in European American or Puerto Rican subjects in the absence of local African ancestry, suggesting that the association with asthma at rs1361549 is due to an environmental or genetic interaction. Conclusion: We identified a novel asthma-associated locus that is relevant to admixed populations with African ancestry and highlight the importance of considering local ancestry in genetic association studies of admixed populations.

Article

Models of Interinstitutional Partnerships between Research Intensive Universities and Minority Serving Institutions (MSI) across the Clinical Translational Science Award (CTSA) Consortium

by Elizabeth O. Ofili; Alecia Fair; Keith Norris; Joseph G. Verbalis; Russell Poland; Gordon Bernard; David Stephens; Steven M. Dubinett; Julianne Imperato-McGinley; Robert P. Dottin; Jill Pulley; Andrew West; Arleen Brown; Thomas A. Mellman

2013

Subjects
  • Health Sciences, Medicine and Surgery
  • Health Sciences, General
  • File Download
  • View Abstract

Abstract:Close

Health disparities are an immense challenge to American society. Clinical and Translational Science Awards (CTSAs) housed within the National Center for Advancing Translational Science (NCATS) are designed to accelerate the translation of experimental findings into clinically meaningful practices and bring new therapies to the doorsteps of all patients. Research Centers at Minority Institutions (RCMI) program at the National Institute on Minority Health and Health Disparities (NIMHD) are designed to build capacity for biomedical research and training at minority serving institutions. The CTSA created a mechanism fostering formal collaborations between research intensive universities and minority serving institutions (MSI) supported by the RCMI program. These consortium-level collaborations activate unique translational research approaches to reduce health disparities with credence to each academic institutions history and unique characteristics. Five formal partnerships between research intensive universities and MSI have formed as a result of the CTSA and RCMI programs. These partnerships present a multifocal approach; shifting cultural change and consciousness toward addressing health disparities, and training the next generation of minority scientists. This collaborative model is based on the respective strengths and contributions of the partnering institutions, allowing bidirectional interchange and leveraging NIH and institutional investments providing measurable benchmarks toward the elimination of health disparities.
Site Statistics
  • 16,941
  • Total Works
  • 3,667,900
  • Downloads
  • 1,143,811
  • Downloads This Year
  • 6,807
  • Faculty Profiles

Copyright © 2016 Emory University - All Rights Reserved
540 Asbury Circle, Atlanta, GA 30322-2870
(404) 727-6861
Privacy Policy | Terms & Conditions

v2.2.8-dev

Contact Us Recent and Popular Items
Download now