Skip to navigation Skip to content
  • Woodruff
  • Business
  • Health Sciences
  • Law
  • MARBL
  • Oxford College
  • Theology
  • Schools
    • Undergraduate

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing

      Community

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing
    • Graduate

      • Business School
      • Graduate School
      • School of Law
      • School of Medicine
      • School of Nursing
      • School of Public Health
      • School of Theology
  • Libraries
    • Libraries

      • Robert W. Woodruff
      • Business
      • Chemistry
      • Health Sciences
      • Law
      • MARBL
      • Music & Media
      • Oxford College
      • Theology
    • Library Tools

      • Course Reserves
      • Databases
      • Digital Scholarship (ECDS)
      • discoverE
      • eJournals
      • Electronic Dissertations
      • EmoryFindingAids
      • EUCLID
      • ILLiad
      • OpenEmory
      • Research Guides
  • Resources
    • Resources

      • Administrative Offices
      • Emory Healthcare
      • Academic Calendars
      • Bookstore
      • Campus Maps
      • Shuttles and Parking
      • Athletics: Emory Eagles
      • Arts at Emory
      • Michael C. Carlos Museum
      • Emory News Center
      • Emory Report
    • Resources

      • Emergency Contacts
      • Information Technology (IT)
      • Outlook Web Access
      • Office 365
      • Blackboard
      • OPUS
      • PeopleSoft Financials: Compass
      • Careers
      • Human Resources
      • Emory Alumni Association
  • Browse
    • Works by Author
    • Works by Journal
    • Works by Subject
    • Works by Dept
    • Faculty by Dept
  • For Authors
    • How to Submit
    • Deposit Advice
    • Author Rights
    • Publishing Your Data
    • FAQ
    • Emory Open Access Policy
    • Open Access Fund
  • About OpenEmory
    • About OpenEmory
    • About Us
    • Citing Articles
    • Contact Us
    • Privacy Policy
    • Terms of Use
 
Contact Us

Filter Results:

Year

  • 2014 (1)
  • 2015 (1)

Author

  • Eisenschenk, Stephan (2)
  • Goldman, Alica (2)
  • Gross, Robert (2)
  • Salanova, Vicenta (2)
  • Barkley, Gregory L (1)
  • Barkley, Gregory L. (1)
  • Bazil, Carl (1)
  • Berg, Michel J (1)
  • Bergey, Gregory K (1)
  • Bergey, Gregory K. (1)
  • Cole, Andrew J (1)
  • Cole, Andrew J. (1)
  • Courtney, Tracy A. (1)
  • Duckrow, Robert B. (1)
  • Edwards, Jonathan C (1)
  • Edwards, Jonathan C. (1)
  • Fessler, James (1)
  • Fountain, Nathan B (1)
  • Fountain, Nathan B. (1)
  • Geller, Eric (1)
  • Geller, Eric B (1)
  • Gwinn, Ryder P (1)
  • Gwinn, Ryder P. (1)
  • Heck, Christianne N (1)
  • Heck, Christianne N. (1)
  • Hirsch, Lawrence J (1)
  • Hirsch, Lawrence J. (1)
  • Jobst, Barbara (1)
  • Jobst, Barbara C. (1)
  • Laxer, Kenneth D (1)
  • Leiphart, James W. (1)
  • Massey, Andrew D. (1)
  • Miller, Ian (1)
  • Miller, Ian O (1)
  • Mirro, Emily (1)
  • Morrell, Martha J (1)
  • Morrell, Martha J. (1)
  • Nair, Dileep R (1)
  • Nair, Dileep R. (1)
  • O'Donovan, Cormac A. (1)
  • Park, Yong D (1)
  • Park, Yong D. (1)
  • Rossi, Marvin A (1)
  • Rutecki, Paul A (1)
  • Rutecki, Paul A. (1)
  • Sadler, Toni L (1)
  • Seale, Caim G. (1)
  • Shields, Donald C (1)
  • Skidmore, Christopher (1)
  • Smith, Michael C. (1)
  • Spencer, David C (1)
  • Spencer, David C. (1)
  • Sperling, Michael R (1)
  • Sun, Felice T (1)
  • Sun, Felice T. (1)
  • Van Ness, Paul C (1)
  • Van Ness, Paul C. (1)
  • Weber, Peter B (1)
  • Wharen, Robert E (1)
  • Wharen, Robert E. (1)
  • Worrell, Gregory A (1)
  • Worrell, Gregory A. (1)
  • Zimmerman, Richard (1)

Subject

  • Health Sciences, Medicine and Surgery (2)

Journal

  • Epilepsia (2)

Keyword

  • biomedicin (2)
  • brain (2)
  • clinic (2)
  • life (2)
  • neurolog (2)
  • neurosci (2)
  • partial (2)
  • respons (2)
  • scienc (2)
  • seizur (2)
  • technolog (2)
  • trial (2)
  • adult (1)
  • ambulatori (1)
  • antiepilept (1)
  • control (1)
  • controlledtri (1)
  • cortic (1)
  • deep (1)
  • deepbrainstimul (1)
  • drug (1)
  • eeg (1)
  • electr (1)
  • electricalstimul (1)
  • electrocorticographi (1)
  • epilepsi (1)
  • focal (1)
  • intracrani (1)
  • lobe (1)
  • local (1)
  • long (1)
  • longterm (1)
  • monitor (1)
  • nerv (1)
  • nervestimul (1)
  • neurostimul (1)
  • of (1)
  • qualiti (1)
  • qualityoflif (1)
  • random (1)
  • recurr (1)
  • refractori (1)
  • standard (1)
  • standardssubcommitte (1)
  • subcommitte (1)
  • surgeri (1)
  • tempor (1)
  • temporallob (1)
  • term (1)
  • vagus (1)
  • withdraw (1)

Author department

  • Neurosurgery: Admin (2)

Search Results for all work with filters:

  • King-Stephens, David
  • Biology, Neuroscience
  • stimul

Work 1-2 of 2

Sorted by relevance

Article

Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial

by Christianne N. Heck; David King-Stephens; Andrew D. Massey; Dileep R. Nair; Barbara C. Jobst; Gregory L. Barkley; Vicenta Salanova; Andrew J. Cole; Michael C. Smith; Ryder P. Gwinn; Christopher Skidmore; Paul C. Van Ness; Gregory K. Bergey; Yong D. Park; Ian Miller; Eric Geller; Paul A. Rutecki; Richard Zimmerman; David C. Spencer; Alica Goldman; Jonathan C. Edwards; James W. Leiphart; Robert E. Wharen; James Fessler; Nathan B. Fountain; Gregory A. Worrell; Robert Gross; Stephan Eisenschenk; Robert B. Duckrow; Lawrence J. Hirsch; Carl Bazil; Cormac A. O'Donovan; Felice T. Sun; Tracy A. Courtney; Caim G. Seale; Martha J. Morrell

2014

Subjects
  • Biology, Neuroscience
  • Health Sciences, Medicine and Surgery
  • File Download
  • View Abstract

Abstract:Close

Objective To demonstrate the safety and effectiveness of responsive stimulation at the seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with medically intractable partial onset seizures arising from one or two seizure foci. Methods Randomized multicenter double-blinded controlled trial of responsive focal cortical stimulation (RNS System). Subjects with medically intractable partial onset seizures from one or two foci were implanted, and 1 month postimplant were randomized 1:1 to active or sham stimulation. After the fifth postimplant month, all subjects received responsive stimulation in an open label period (OLP) to complete 2 years of postimplant follow-up. Results All 191 subjects were randomized. The percent change in seizures at the end of the blinded period was -37.9% in the active and -17.3% in the sham stimulation group (p = 0.012, Generalized Estimating Equations). The median percent reduction in seizures in the OLP was 44% at 1 year and 53% at 2 years, which represents a progressive and significant improvement with time (p < 0.0001). The serious adverse event rate was not different between subjects receiving active and sham stimulation. Adverse events were consistent with the known risks of an implanted medical device, seizures, and of other epilepsy treatments. There were no adverse effects on neuropsychological function or mood. Significance Responsive stimulation to the seizure focus reduced the frequency of partial-onset seizures acutely, showed improving seizure reduction over time, was well tolerated, and was acceptably safe. The RNS System provides an additional treatment option for patients with medically intractable partial-onset seizures.

Article

Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography

by David King-Stephens; Emily Mirro; Peter B Weber; Kenneth D Laxer; Paul C Van Ness; Vicenta Salanova; David C Spencer; Christianne N Heck; Alica Goldman; Barbara Jobst; Donald C Shields; Gregory K Bergey; Stephan Eisenschenk; Gregory A Worrell; Marvin A Rossi; Robert Gross; Andrew J Cole; Michael R Sperling; Dileep R Nair; Ryder P Gwinn; Yong D Park; Paul A Rutecki; Nathan B Fountain; Robert E Wharen; Lawrence J Hirsch; Ian O Miller; Gregory L Barkley; Jonathan C Edwards; Eric B Geller; Michel J Berg; Toni L Sadler; Felice T Sun; Martha J Morrell

2015

Subjects
  • Biology, Neuroscience
  • Health Sciences, Medicine and Surgery
  • File Download
  • View Abstract

Abstract:Close

Objective: Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with MTL epilepsy may provide additional information about seizure lateralization. This analysis describes data obtained from chronic ambulatory ECoG in patients with suspected bilateral MTL epilepsy in order to assess the time required to determine the seizure lateralization and whether this information could influence treatment decisions. Methods: Ambulatory ECoG was reviewed in patients with suspected bilateral MTL epilepsy who were among a larger cohort with intractable epilepsy participating in a randomized controlled trial of responsive neurostimulation. Subjects were implanted with bilateral MTL leads and a cranially implanted neurostimulator programmed to detect abnormal interictal and ictal ECoG activity. ECoG data stored by the neurostimulator were reviewed to determine the lateralization of electrographic seizures and the interval of time until independent bilateral MTL electrographic seizures were recorded. Results: Eighty-two subjects were implanted with bilateral MTL leads and followed for 4.7 years on average (median 4.9 years). Independent bilateral MTL electrographic seizures were recorded in 84%. The average time to record bilateral electrographic seizures in the ambulatory setting was 41.6 days (median 13 days, range 0-376 days). Sixteen percent had only unilateral electrographic seizures after an average of 4.6 years of recording. Significance: About one third of the subjects implanted with bilateral MTL electrodes required >1 month of chronic ambulatory ECoG before the first contralateral MTL electrographic seizure was recorded. Some patients with suspected bilateral MTL seizures had only unilateral electrographic seizures. Chronic ambulatory ECoG in patients with suspected bilateral MTL seizures provides data in a naturalistic setting, may complement data from inpatient video-EEG monitoring, and can contribute to treatment decisions.
Site Statistics
  • 16,941
  • Total Works
  • 3,665,017
  • Downloads
  • 1,140,928
  • Downloads This Year
  • 6,807
  • Faculty Profiles

Copyright © 2016 Emory University - All Rights Reserved
540 Asbury Circle, Atlanta, GA 30322-2870
(404) 727-6861
Privacy Policy | Terms & Conditions

v2.2.8-dev

Contact Us Recent and Popular Items
Download now