Skip to navigation Skip to content
  • Woodruff
  • Business
  • Health Sciences
  • Law
  • MARBL
  • Oxford College
  • Theology
  • Schools
    • Undergraduate

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing

      Community

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing
    • Graduate

      • Business School
      • Graduate School
      • School of Law
      • School of Medicine
      • School of Nursing
      • School of Public Health
      • School of Theology
  • Libraries
    • Libraries

      • Robert W. Woodruff
      • Business
      • Chemistry
      • Health Sciences
      • Law
      • MARBL
      • Music & Media
      • Oxford College
      • Theology
    • Library Tools

      • Course Reserves
      • Databases
      • Digital Scholarship (ECDS)
      • discoverE
      • eJournals
      • Electronic Dissertations
      • EmoryFindingAids
      • EUCLID
      • ILLiad
      • OpenEmory
      • Research Guides
  • Resources
    • Resources

      • Administrative Offices
      • Emory Healthcare
      • Academic Calendars
      • Bookstore
      • Campus Maps
      • Shuttles and Parking
      • Athletics: Emory Eagles
      • Arts at Emory
      • Michael C. Carlos Museum
      • Emory News Center
      • Emory Report
    • Resources

      • Emergency Contacts
      • Information Technology (IT)
      • Outlook Web Access
      • Office 365
      • Blackboard
      • OPUS
      • PeopleSoft Financials: Compass
      • Careers
      • Human Resources
      • Emory Alumni Association
  • Browse
    • Works by Author
    • Works by Journal
    • Works by Subject
    • Works by Dept
    • Faculty by Dept
  • For Authors
    • How to Submit
    • Deposit Advice
    • Author Rights
    • Publishing Your Data
    • FAQ
    • Emory Open Access Policy
    • Open Access Fund
  • About OpenEmory
    • About OpenEmory
    • About Us
    • Citing Articles
    • Contact Us
    • Privacy Policy
    • Terms of Use
 
Contact Us

Filter Results:

Year

  • 2017 (1)

Author

  • Depoy, Lauren M. (1)
  • Gourley, Shannon L (1)
  • Marvar, Paul J. (1)
  • Zimmermann, Kelsey S. (1)

Subject

  • Health Sciences, Medicine and Surgery (1)

Journal

  • Biological Psychiatry (1)

Keyword

  • 2 (1)
  • abl (1)
  • amygdala (1)
  • arg (1)
  • b (1)
  • basolater (1)
  • bcontain (1)
  • biomedicin (1)
  • contain (1)
  • dendrit (1)
  • discrimin (1)
  • glutamaterg (1)
  • ifenprodil (1)
  • incub (1)
  • kinas (1)
  • life (1)
  • long (1)
  • longterm (1)
  • neurolog (1)
  • neurosci (1)
  • nmda (1)
  • nr (1)
  • ofc (1)
  • orbit (1)
  • orbitofront (1)
  • outcom (1)
  • plastic (1)
  • potenti (1)
  • prefront (1)
  • psychiatri (1)
  • respons (1)
  • scienc (1)
  • spine (1)
  • stimulus (1)
  • synapt (1)
  • technolog (1)
  • term (1)

Author department

  • Peds: Marcus Center (1)

Search Results for all work with filters:

  • Biology, Neuroscience
  • receptor
  • inhibitor
  • cortex
  • responseoutcom

Work 1 of 1

Sorted by relevance

Article

Induction and Blockade of Adolescent Cocaine-Induced Habits

by Lauren M. Depoy; Kelsey S. Zimmermann; Paul J. Marvar; Shannon L Gourley

2017

Subjects
  • Health Sciences, Medicine and Surgery
  • Biology, Neuroscience
  • File Download
  • View Abstract

Abstract:Close

Cocaine use during adolescence increases vulnerability to drug dependence and decreases the likelihood that individuals will seek treatment as adults. Understanding how early-life cocaine exposure influences decision-making processes in adulthood is thus critically important. Methods Adolescent or adult mice were exposed to subchronic cocaine, then behavioral sensitivity to changes in the predictive relationship between actions and their consequences was tested. Dendritic spines on the principal pyramidal neurons of the orbitofrontal prefrontal cortex (oPFC) were also imaged and enumerated. To determine whether cytoskeletal regulatory systems in the oPFC influenced decision-making strategies, we then inhibited the activity of Abl family and Rho kinases as well as NR2B-containing N-methyl-D-aspartate receptors. We also attempted to block the reinstatement of cocaine seeking in cocaine self-administering mice. Results Adult mice with a history of subchronic cocaine exposure in adolescence engaged habit-based response strategies at the expense of goal-directed decision-making strategies and had fewer dendritic spines in the oPFC. Inhibition of the cytoskeletal regulatory Abl family kinases in the oPFC recapitulated these neurobehavioral deficiencies, whereas Rho kinase inhibition corrected response strategies. Additionally, the NR2B-selective N-methyl-D-aspartate receptor antagonists ifenprodil and CP-101,606 blocked cocaine-induced habits; this was dependent on Abl family signaling in the oPFC. Ifenprodil also mitigated cue-induced reinstatement of cocaine seeking in mice self-administering cocaine. Conclusions We suggest that adolescent cocaine exposure confers a bias toward habit-based behavior in adulthood via long-term cellular structural modifications in the oPFC. Treatments aimed at mitigating the durable consequences of early-life cocaine use may benefit from targeting cytoskeletal regulatory systems.
Site Statistics
  • 16,733
  • Total Works
  • 3,623,692
  • Downloads
  • 1,099,603
  • Downloads This Year
  • 6,807
  • Faculty Profiles

Copyright © 2016 Emory University - All Rights Reserved
540 Asbury Circle, Atlanta, GA 30322-2870
(404) 727-6861
Privacy Policy | Terms & Conditions

v2.2.8-dev

Contact Us Recent and Popular Items
Download now