Skip to navigation Skip to content
  • Woodruff
  • Business
  • Health Sciences
  • Law
  • MARBL
  • Oxford College
  • Theology
  • Schools
    • Undergraduate

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing

      Community

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing
    • Graduate

      • Business School
      • Graduate School
      • School of Law
      • School of Medicine
      • School of Nursing
      • School of Public Health
      • School of Theology
  • Libraries
    • Libraries

      • Robert W. Woodruff
      • Business
      • Chemistry
      • Health Sciences
      • Law
      • MARBL
      • Music & Media
      • Oxford College
      • Theology
    • Library Tools

      • Course Reserves
      • Databases
      • Digital Scholarship (ECDS)
      • discoverE
      • eJournals
      • Electronic Dissertations
      • EmoryFindingAids
      • EUCLID
      • ILLiad
      • OpenEmory
      • Research Guides
  • Resources
    • Resources

      • Administrative Offices
      • Emory Healthcare
      • Academic Calendars
      • Bookstore
      • Campus Maps
      • Shuttles and Parking
      • Athletics: Emory Eagles
      • Arts at Emory
      • Michael C. Carlos Museum
      • Emory News Center
      • Emory Report
    • Resources

      • Emergency Contacts
      • Information Technology (IT)
      • Outlook Web Access
      • Office 365
      • Blackboard
      • OPUS
      • PeopleSoft Financials: Compass
      • Careers
      • Human Resources
      • Emory Alumni Association
  • Browse
    • Works by Author
    • Works by Journal
    • Works by Subject
    • Works by Dept
    • Faculty by Dept
  • For Authors
    • How to Submit
    • Deposit Advice
    • Author Rights
    • Publishing Your Data
    • FAQ
    • Emory Open Access Policy
    • Open Access Fund
  • About OpenEmory
    • About OpenEmory
    • About Us
    • Citing Articles
    • Contact Us
    • Privacy Policy
    • Terms of Use
 
Contact Us

Filter Results:

Year

  • 2016 (1)

Author

  • Ailawadhi, Sikander (1)
  • Ambrosone, Christine B. (1)
  • Anderson, Kenneth C. (1)
  • Atanackovic, Djordje (1)
  • Bandera, Elisa V. (1)
  • Berndt, Sonja (1)
  • Bernstein, Leslie (1)
  • Bhatti, Parveen (1)
  • Birmann, Brenda M. (1)
  • Blot, William J. (1)
  • Bock, Cathryn H. (1)
  • Brooks-Wilson, Angela R. (1)
  • Brown, Elizabeth E. (1)
  • Camp, Nicola J. (1)
  • Cannon-Albright, Lisa A. (1)
  • Carpten, John (1)
  • Casey, Graham (1)
  • Chanock, Stephen J. (1)
  • Chiu, Brian C. (1)
  • Chu, Lisa (1)
  • Colditz, Graham A. (1)
  • Conti, David V. (1)
  • Cozen, Wendy (1)
  • Curtin, Karen (1)
  • De Roos, Anneclaire J. (1)
  • Dean, Eric (1)
  • Diver, W. Ryan (1)
  • Edlund, Christopher K. (1)
  • Giles, Graham G. (1)
  • Glenn, Martha J. (1)
  • Goodman, Phyllis J. (1)
  • Graff, John (1)
  • Haiman, Christopher A. (1)
  • Halverson, Sandra L. (1)
  • Hazelett, Dennis J. (1)
  • Hennis, Anselm J.M. (1)
  • Hsing, Ann W. (1)
  • Hu, Donglei (1)
  • Hu, Jennifer J. (1)
  • Huff, Carol Ann (1)
  • Hwang, Amie E. (1)
  • Ingles, Sue A. (1)
  • Janakiraman, Nalini (1)
  • John, Esther M. (1)
  • Jones, Brandt (1)
  • Kittles, Rick A. (1)
  • Klein, Eric A. (1)
  • Kolb, Suzanne (1)
  • Kolonel, Laurence N. (1)
  • Kong, Yinfei (1)
  • Kumar, Shaji K. (1)
  • Leske, Cristina (1)
  • Levy, Joan (1)
  • Lieber, Michael R. (1)
  • Lonial, Sagar (1)
  • Martin, Thomas G. (1)
  • Mehta, Jayesh (1)
  • Mohrbacher, Ann F. (1)
  • Munshi, Nikhil C. (1)
  • Murphy, Adam B. (1)
  • Nemesure, Barbara (1)
  • Neslund-Dudas, Christine (1)
  • Nooka, Ajay (1)
  • Nyante, Sarah J. (1)
  • Olshan, Andrew F. (1)
  • Orlowski, Robert Z. (1)
  • Pawlish, Karen (1)
  • Peters, Edward S. (1)
  • Pregja, Silvana L. (1)
  • Press, Michael F. (1)
  • Rajkumar, S. Vincent (1)
  • Rand, Kristin A. (1)
  • Rothman, Nathaniel (1)
  • Rybicki, Benjamin A. (1)
  • Serie, Daniel J. (1)
  • Severson, Richard K. (1)
  • Sheng, Xin (1)
  • Signorello, Lisa B. (1)
  • Singhal, Seema (1)
  • Slager, Susan L. (1)
  • Song, Chi (1)
  • Spinelli, John J. (1)
  • Stanford, Janet L. (1)
  • Stevens, Victoria L. (1)
  • Stram, Alex (1)
  • Stram, Daniel O. (1)
  • Strom, Sara S. (1)
  • Terebelo, Howard R. (1)
  • Tomasson, Michael H. (1)
  • Tricot, Guido (1)
  • Vachon, Celine M. (1)
  • Van den Berg, David J. (1)
  • Vij, Ravi (1)
  • Witte, John S. (1)
  • Wolf, Jeffrey L. (1)
  • Zheng, Wei (1)
  • Ziegler, Regina C. (1)
  • Zimmerman, Todd (1)

Subject

  • Health Sciences, Oncology (1)

Journal

  • Cancer Epidemiology, Biomarkers and Prevention (1)

Keyword

  • 15 (1)
  • 153 (1)
  • 3 (1)
  • 7 (1)
  • associ (1)
  • biomedicin (1)
  • environment (1)
  • gammopathi (1)
  • genom (1)
  • genomewid (1)
  • genotyp (1)
  • health (1)
  • life (1)
  • los (1)
  • losangel (1)
  • monoclon (1)
  • occup (1)
  • p (1)
  • pattern (1)
  • public (1)
  • scienc (1)
  • signific (1)
  • site (1)
  • target (1)
  • technolog (1)
  • undetermin (1)
  • variant (1)
  • wide (1)

Author department

  • HMO: BMT (1)
  • HMO: Hematology (1)

Search Results for all work with filters:

  • Bernal-Mizrachi, Leon
  • Huntsman, Scott
  • Health Sciences, General
  • oncolog
  • angel

Work 1 of 1

Sorted by relevance

Article

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci

by Kristin A. Rand; Chi Song; Eric Dean; Daniel J. Serie; Karen Curtin; Xin Sheng; Donglei Hu; Carol Ann Huff; Leon Bernal-Mizrachi; Michael H. Tomasson; Sikander Ailawadhi; Seema Singhal; Karen Pawlish; Edward S. Peters; Cathryn H. Bock; Alex Stram; David J. Van den Berg; Christopher K. Edlund; David V. Conti; Todd Zimmerman; Amie E. Hwang; Scott Huntsman; John Graff; Ajay Nooka; Yinfei Kong; Silvana L. Pregja; Sonja Berndt; William J. Blot; John Carpten; Graham Casey; Lisa Chu; W. Ryan Diver; Victoria L. Stevens; Michael R. Lieber; Phyllis J. Goodman; Anselm J.M. Hennis; Ann W. Hsing; Jayesh Mehta; Rick A. Kittles; Suzanne Kolb; Eric A. Klein; Cristina Leske; Adam B. Murphy; Barbara Nemesure; Christine Neslund-Dudas; Sara S. Strom; Ravi Vij; Benjamin A. Rybicki; Janet L. Stanford; Lisa B. Signorello; John S. Witte; Christine B. Ambrosone; Parveen Bhatti; Esther M. John; Leslie Bernstein; Wei Zheng; Andrew F. Olshan; Jennifer J. Hu; Regina C. Ziegler; Sarah J. Nyante; Elisa V. Bandera; Brenda M. Birmann; Sue A. Ingles; Michael F. Press; Djordje Atanackovic; Martha J. Glenn; Lisa A. Cannon-Albright; Brandt Jones; Guido Tricot; Thomas G. Martin; Shaji K. Kumar; Jeffrey L. Wolf; Sandra L. Halverson; Nathaniel Rothman; Angela R. Brooks-Wilson; S. Vincent Rajkumar; Laurence N. Kolonel; Stephen J. Chanock; Susan L. Slager; Richard K. Severson; Nalini Janakiraman; Howard R. Terebelo; Elizabeth E. Brown; Anneclaire J. De Roos; Ann F. Mohrbacher; Graham A. Colditz; Graham G. Giles; John J. Spinelli; Brian C. Chiu; Nikhil C. Munshi; Kenneth C. Anderson; Joan Levy; Jeffrey A. Zonder; Robert Z. Orlowski; Sagar Lonial; Nicola J. Camp; Celine M. Vachon; Elad Ziv; Daniel O. Stram; Dennis J. Hazelett; Christopher A. Haiman; Wendy Cozen

2016

Subjects
  • Health Sciences, Oncology
  • Health Sciences, General
  • File Download
  • View Abstract

Abstract:Close

Background: Genome-wide association studies (GWAS) in European populations have identified genetic risk variants associated with multiple myeloma. Methods: We performed association testing of common variation in eight regions in 1,318 patients with multiple myeloma and 1,480 controls of European ancestry and 1,305 patients with multiple myeloma and 7,078 controls of African ancestry and conducted a meta-analysis to localize the signals, with epigenetic annotation used to predict functionality. Results: We found that variants in 7p15.3, 17p11.2, 22q13.1 were statistically significantly (P < 0.05) associated with multiple myeloma risk in persons of African ancestry and persons of European ancestry, and the variant in 3p22.1 was associated in European ancestry only. In a combined African ancestry- European ancestry meta-analysis, variation in five regions (2p23.3, 3p22.1, 7p15.3, 17p11.2, 22q13.1) was statistically significantly associated with multiple myeloma risk. In 3p22.1, the correlated variants clustered within the gene body of ULK4. Correlated variants in 7p15.3 clustered around an enhancer at the 30 end of the CDCA7L transcription termination site. A missense variant at 17p11.2 (rs34562254, Pro251Leu, OR, 1.32; P = 2.93 × 10 -7 ) in TNFRSF13B encodes a lymphocyte-specific protein in the TNF receptor family that interacts with the NF-kB pathway. SNPs correlated with the index signal in 22q13.1 cluster around the promoter and enhancer regions of CBX7. Conclusions: We found that reported multiple myeloma susceptibility regions contain risk variants important across populations, supporting the use of multiple racial/ethnic groups with different underlying genetic architecture to enhance the localization and identification of putatively functional alleles. Impact: A subset of reported risk loci for multiple myeloma has consistent effects across populations and is likely to be functional.
Site Statistics
  • 16,751
  • Total Works
  • 3,621,576
  • Downloads
  • 1,097,487
  • Downloads This Year
  • 6,807
  • Faculty Profiles

Copyright © 2016 Emory University - All Rights Reserved
540 Asbury Circle, Atlanta, GA 30322-2870
(404) 727-6861
Privacy Policy | Terms & Conditions

v2.2.8-dev

Contact Us Recent and Popular Items
Download now