Background and Purpose-This study aims to describe the relationship between computed tomographic (CT) perfusion (CTP)-to-reperfusion time and clinical and radiological outcomes, in a cohort of patients who achieve successful reperfusion for acute ischemic stroke. Methods-We included data from the CRISP (Computed Tomographic Perfusion to Predict Response in Ischemic Stroke Project) in which all patients underwent a baseline CTP scan before endovascular therapy. Patients were included if they had a mismatch on their baseline CTP scan and achieved successful endovascular reperfusion. Patients with mismatch were categorized into target mismatch and malignant mismatch profles, according to the volume of their Tmax >10s lesion volume (target mismatch, <100 mL; malignant mismatch, >100 mL). We investigated the impact of CTP-toreperfusion times on probability of achieving functional independence (modifed Rankin Scale, 0-2) at day 90 and radiographic outcomes at day 5. Results-Of 156 included patients, 108 (59%) had the target mismatch profle, and 48 (26%) had the malignant mismatch profle. In patients with the target mismatch profle, CTP-to-reperfusion time showed no association with functional independence (P=0.84), whereas in patients with malignant mismatch profle, CTP-to-reperfusion time was strongly associated with lower probability of functional independence (odds ratio, 0.08; P=0.003). Compared with patients with target mismatch, those with the malignant mismatch profle had signifcantly more infarct growth (90 [49-166] versus 43 [18-81] mL; P=0.006) and larger fnal infarct volumes (110 [61-155] versus 48 [21-99] mL; P=0.001). Conclusions-Compared with target mismatch patients, those with the malignant profle experience faster infarct growth and a steeper decline in the odds of functional independence, with longer delays between baseline imaging and reperfusion. However, this does not exclude the possibility of treatment beneft in patients with a malignant profle.