Skip to navigation Skip to content
  • Woodruff
  • Business
  • Health Sciences
  • Law
  • MARBL
  • Oxford College
  • Theology
  • Schools
    • Undergraduate

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing

      Community

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing
    • Graduate

      • Business School
      • Graduate School
      • School of Law
      • School of Medicine
      • School of Nursing
      • School of Public Health
      • School of Theology
  • Libraries
    • Libraries

      • Robert W. Woodruff
      • Business
      • Chemistry
      • Health Sciences
      • Law
      • MARBL
      • Music & Media
      • Oxford College
      • Theology
    • Library Tools

      • Course Reserves
      • Databases
      • Digital Scholarship (ECDS)
      • discoverE
      • eJournals
      • Electronic Dissertations
      • EmoryFindingAids
      • EUCLID
      • ILLiad
      • OpenEmory
      • Research Guides
  • Resources
    • Resources

      • Administrative Offices
      • Emory Healthcare
      • Academic Calendars
      • Bookstore
      • Campus Maps
      • Shuttles and Parking
      • Athletics: Emory Eagles
      • Arts at Emory
      • Michael C. Carlos Museum
      • Emory News Center
      • Emory Report
    • Resources

      • Emergency Contacts
      • Information Technology (IT)
      • Outlook Web Access
      • Office 365
      • Blackboard
      • OPUS
      • PeopleSoft Financials: Compass
      • Careers
      • Human Resources
      • Emory Alumni Association
  • Browse
    • Works by Author
    • Works by Journal
    • Works by Subject
    • Works by Dept
    • Faculty by Dept
  • For Authors
    • How to Submit
    • Deposit Advice
    • Author Rights
    • Publishing Your Data
    • FAQ
    • Emory Open Access Policy
    • Open Access Fund
  • About OpenEmory
    • About OpenEmory
    • About Us
    • Citing Articles
    • Contact Us
    • Privacy Policy
    • Terms of Use
 
Contact Us

Filter Results:

Year

  • 2015 (1)

Author

  • Albert, Marilyn S. (1)
  • Albin, Roger L. (1)
  • Apostolova, Liana G. (1)
  • Arnold, Steven E. (1)
  • Asthana, Sanjay (1)
  • Atwood, Craig S. (1)
  • Baldwin, Clinton T. (1)
  • Barber, Robert C. (1)
  • Barmada, Michael M. (1)
  • Barnes, Lisa L. (1)
  • Beach, Thomas G. (1)
  • Becker, James T. (1)
  • Beecham, Gary W. (1)
  • Beekly, Duane (1)
  • Bigio, Eileen H. (1)
  • Bird, Thomas D. (1)
  • Blacker, Deborah (1)
  • Boehme, Kevin L. (1)
  • Boeve, Bradley F. (1)
  • Bowen, James D. (1)
  • Boxer, Adam (1)
  • Burke, James R. (1)
  • Buxbaum, Joseph D. (1)
  • Cairns, Nigel J. (1)
  • Cantwell, Laura B. (1)
  • Cao, Chuanhai (1)
  • Carlson, Chris S. (1)
  • Carlsson, Cynthia M. (1)
  • Carney, Regina M. (1)
  • Carrasquillo, Minerva M. (1)
  • Carroll, Steven L. (1)
  • Chui, Helena C. (1)
  • Clark, David G. (1)
  • Corneveaux, Jason (1)
  • Crane, Paul K. (1)
  • Cribbs, David H. (1)
  • Crocco, Elizabeth A. (1)
  • Cruchaga, Caros (1)
  • Day, Felix (1)
  • De Jager, Philip L. (1)
  • DeCarli, Charles (1)
  • Demirci, F. Yesim (1)
  • Dick, Malcolm (1)
  • Dickson, Dennis W. (1)
  • Duara, Ranjan (1)
  • Ertekin-Taner, Nilufer (1)
  • Evans, Denis (1)
  • Faber, Kelley M. (1)
  • Fallon, Kenneth B. (1)
  • Farlow, Martin R. (1)
  • Farrer, Lindsay A. (1)
  • Ferris, Steven (1)
  • Foroud, Tatiana M. (1)
  • Frosch, Matthew P. (1)
  • Galasko, Douglas R. (1)
  • Gearing, Marla (1)
  • Geschwind, Daniel H. (1)
  • Ghetti, Bernardino (1)
  • Gibbons, Laura E. (1)
  • Gilbert, John R. (1)
  • Glass, Jonathan D (1)
  • Goate, Alison M. (1)
  • Graff-Rafford, Neill R. (1)
  • Green, Robert C. (1)
  • Growden , John H. (1)
  • Haines, Jonathan L. (1)
  • Hakonarson, Hakon (1)
  • Hamilton, Ronald L. (1)
  • Hamilton-Nelson, Kara L. (1)
  • Hardy, John (1)
  • Harrell, Lindy E. (1)
  • Honig, Lawrence S. (1)
  • Kauwe, John S. (1)
  • Lah, James J (1)
  • Langenberg, Claudia (1)
  • Larson, Eric B. (1)
  • Levey, Allan (1)
  • Lotta, Luca A. (1)
  • Mukherjee, Shubhabrata (1)
  • Perry, John R.B. (1)
  • Powell, John F. (1)
  • Proitsi, Patroula (1)
  • Scott, Robert A. (1)
  • Sharp, Stephen J. (1)
  • Walter, Stefan (1)
  • Wareham, Nicholas J. (1)
  • Østergaard, Soren D. (1)

Subject

  • Health Sciences, Epidemiology (1)

Journal

  • PLoS Medicine (1)

Keyword

  • alzheim (1)
  • analysi (1)
  • diseas (1)
  • factor (1)
  • femal (1)
  • human (1)
  • male (1)
  • mendelian (1)
  • nucleotid (1)
  • polymorph (1)
  • predisposit (1)
  • random (1)
  • risk (1)
  • singl (1)

Author department

  • Neurology: Cog Neurobehav (1)
  • Neurology: Neuromuscular (1)

Search Results for all work with filters:

  • Head, Elizabeth
  • Health Sciences, General
  • genet
  • Pathology: Admin

Work 1 of 1

Sorted by relevance

Article

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

by Soren D. Østergaard; Shubhabrata Mukherjee; Stephen J. Sharp; Patroula Proitsi; Luca A. Lotta; Felix Day; John R.B. Perry; Kevin L. Boehme; Stefan Walter; John S. Kauwe; Laura E. Gibbons; Eric B. Larson; John F. Powell; Claudia Langenberg; Paul K. Crane; Nicholas J. Wareham; Robert A. Scott; Marilyn S. Albert; Roger L. Albin; Liana G. Apostolova; Steven E. Arnold; Sanjay Asthana; Craig S. Atwood; Clinton T. Baldwin; Robert C. Barber; Michael M. Barmada; Lisa L. Barnes; Thomas G. Beach; James T. Becker; Gary W. Beecham; Duane Beekly; Eileen H. Bigio; Thomas D. Bird; Deborah Blacker; Bradley F. Boeve; James D. Bowen; Adam Boxer; James R. Burke; Joseph D. Buxbaum; Nigel J. Cairns; Laura B. Cantwell; Chuanhai Cao; Chris S. Carlson; Cynthia M. Carlsson; Regina M. Carney; Minerva M. Carrasquillo; Steven L. Carroll; Helena C. Chui; David G. Clark; Jason Corneveaux; David H. Cribbs; Elizabeth A. Crocco; Caros Cruchaga; Philip L. De Jager; Charles DeCarli; F. Yesim Demirci; Malcolm Dick; Dennis W. Dickson; Ranjan Duara; Nilufer Ertekin-Taner; Denis Evans; Kelley M. Faber; Kenneth B. Fallon; Martin R. Farlow; Lindsay A. Farrer; Steven Ferris; Tatiana M. Foroud; Matthew P. Frosch; Douglas R. Galasko; Marla Gearing; Daniel H. Geschwind; Bernardino Ghetti; John R. Gilbert; Jonathan D Glass; John H. Growden ; Jonathan L. Haines; Hakon Hakonarson; Ronald L. Hamilton; Kara L. Hamilton-Nelson; John Hardy; Lindy E. Harrell; Elizabeth Head; Lawrence S. Honig; Alison M. Goate; Neill R. Graff-Rafford; Robert C. Green; James J Lah; Allan Levey

2015

Subjects
  • Health Sciences, Epidemiology
  • Health Sciences, General
  • File Download
  • View Abstract

Abstract:Close

Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess the causal nature of these associations using Mendelian randomization (MR). We used SNPs associated with each risk factor as instrumental variables in MR analyses. We considered type 2 diabetes (T2D, N SNPs = 49), fasting glucose (N SNPs = 36), insulin resistance (N SNPs = 10), body mass index (BMI, N SNPs = 32), total cholesterol (N SNPs = 73), HDL-cholesterol (N SNPs = 71), LDL-cholesterol (N SNPs = 57), triglycerides (N SNPs = 39), systolic blood pressure (SBP, N SNPs = 24), smoking initiation (N SNPs = 1), smoking quantity (N SNPs = 3), university completion (N SNPs = 2), and years of education (N SNPs = 1). We calculated MR estimates of associations between each exposure and AD risk using an inverse-variance weighted approach, with summary statistics of SNP–AD associations from the International Genomics of Alzheimer’s Project, comprising a total of 17,008 individuals with AD and 37,154 cognitively normal elderly controls. We found that genetically predicted higher SBP was associated with lower AD risk (odds ratio [OR] per standard deviation [15.4 mm Hg] of SBP [95% CI] : 0.75 [0.62–0.91]; p = 3.4 × 10 −3 ). Genetically predicted higher SBP was also associated with a higher probability of taking antihypertensive medication (p = 6.7 × 10 −8 ). Genetically predicted smoking quantity was associated with lower AD risk (OR per ten cigarettes per day [95% CI]: 0.67 [0.51–0.89] ; p = 6.5 × 10 −3 ), although we were unable to stratify by smoking history; genetically predicted smoking initiation was not associated with AD risk (OR = 0.70 [0.37, 1.33]; p = 0.28). We saw no evidence of causal associations between glycemic traits, T2D, BMI, or educational attainment and risk of AD (all p > 0.1). Potential limitations of this study include the small proportion of intermediate trait variance explained by genetic variants and other implicit limitations of MR analyses. Inherited lifetime exposure to higher SBP is associated with lower AD risk. These findings suggest that higher blood pressure—or some environmental exposure associated with higher blood pressure, such as use of antihypertensive medications—may reduce AD risk.
Site Statistics
  • 16,941
  • Total Works
  • 3,661,857
  • Downloads
  • 1,137,768
  • Downloads This Year
  • 6,807
  • Faculty Profiles

Copyright © 2016 Emory University - All Rights Reserved
540 Asbury Circle, Atlanta, GA 30322-2870
(404) 727-6861
Privacy Policy | Terms & Conditions

v2.2.8-dev

Contact Us Recent and Popular Items
Download now