Skip to navigation Skip to content
  • Woodruff
  • Business
  • Health Sciences
  • Law
  • MARBL
  • Oxford College
  • Theology
  • Schools
    • Undergraduate

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing

      Community

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing
    • Graduate

      • Business School
      • Graduate School
      • School of Law
      • School of Medicine
      • School of Nursing
      • School of Public Health
      • School of Theology
  • Libraries
    • Libraries

      • Robert W. Woodruff
      • Business
      • Chemistry
      • Health Sciences
      • Law
      • MARBL
      • Music & Media
      • Oxford College
      • Theology
    • Library Tools

      • Course Reserves
      • Databases
      • Digital Scholarship (ECDS)
      • discoverE
      • eJournals
      • Electronic Dissertations
      • EmoryFindingAids
      • EUCLID
      • ILLiad
      • OpenEmory
      • Research Guides
  • Resources
    • Resources

      • Administrative Offices
      • Emory Healthcare
      • Academic Calendars
      • Bookstore
      • Campus Maps
      • Shuttles and Parking
      • Athletics: Emory Eagles
      • Arts at Emory
      • Michael C. Carlos Museum
      • Emory News Center
      • Emory Report
    • Resources

      • Emergency Contacts
      • Information Technology (IT)
      • Outlook Web Access
      • Office 365
      • Blackboard
      • OPUS
      • PeopleSoft Financials: Compass
      • Careers
      • Human Resources
      • Emory Alumni Association
  • Browse
    • Works by Author
    • Works by Journal
    • Works by Subject
    • Works by Dept
    • Faculty by Dept
  • For Authors
    • How to Submit
    • Deposit Advice
    • Author Rights
    • Publishing Your Data
    • FAQ
    • Emory Open Access Policy
    • Open Access Fund
  • About OpenEmory
    • About OpenEmory
    • About Us
    • Citing Articles
    • Contact Us
    • Privacy Policy
    • Terms of Use
 
Contact Us

Filter Results:

Year

  • 2019 (1)

Author

  • Aleksandrova, Krasimira (1)
  • Aune, Dagfinn (1)
  • Barricarte, Aurelio (1)
  • Boutron-Ruault, Marie-Christine (1)
  • Bradbury, Kathryn E. (1)
  • Bueno-de-Mesquita, Bas (1)
  • Fedirko, Veronika (1)
  • Freisling, Heinz (1)
  • Gunter, Marc (1)
  • Gylling, Bjorn (1)
  • Harlid, Sophia (1)
  • Hesketh, John E. (1)
  • Hughes, David J. (1)
  • Hybsier, Sandra (1)
  • Jenab, Mazda (1)
  • Jones, Jeb (1)
  • Karakatsani, Anna (1)
  • Katzke, Verena (1)
  • Khaw, Kay-Tee (1)
  • Kotanidou, Anastasia (1)
  • Kuehn, Tilman (1)
  • Lujan-Barroso, Leila (1)
  • Maria Huerta, Jose (1)
  • Meplan, Catherine (1)
  • Murphy, Neil (1)
  • Naccarati, Alessio (1)
  • Nost, Therese Haugdahl (1)
  • Omichessan, Hanane (1)
  • Overvad, Kim (1)
  • Panico, Salvatore (1)
  • Perduca, Vittorio (1)
  • Ramon Quiros, J. (1)
  • Riboli, Elio (1)
  • Rodriguez-Barranco, Miguel (1)
  • Schomburg, Lutz (1)
  • Siddiq, Afshan (1)
  • Skeie, Guri (1)
  • Tjonneland, Anne (1)
  • Trichopoulou, Antonia (1)
  • Tsilidis, Kostas (1)
  • Tumino, Rosario (1)
  • Vermeulen, Roel C.H. (1)
  • Wareham, Nick (1)
  • Weiderpass, Elisabete (1)
  • Zhu, Wanzhe (1)

Subject

  • Health Sciences, Epidemiology (1)
  • Health Sciences, Nutrition (1)
  • Health Sciences, Oncology (1)

Keyword

  • architectur (1)
  • biomark (1)
  • biomedicin (1)
  • cancer (1)
  • cohort (1)
  • colorect (1)
  • crohn (1)
  • crohnsdiseas (1)
  • diseas (1)
  • epidemiolog (1)
  • frizzl (1)
  • frizzledrel (1)
  • genet (1)
  • geneticvari (1)
  • health (1)
  • life (1)
  • megalin (1)
  • metaanalysi (1)
  • neoplasm (1)
  • nutrit (1)
  • p (1)
  • pathway (1)
  • polymorph (1)
  • prospect (1)
  • protein (1)
  • relat (1)
  • risk (1)
  • scienc (1)
  • selenium (1)
  • selenoprotein (1)
  • status (1)
  • suscept (1)
  • technolog (1)
  • variant (1)
  • variat (1)

Author affiliation

  • Winship Cancer Institute (1)

Author department

  • Epidemiology (1)

Search Results for all work with filters:

  • Agnoli, Claudia
  • Masala, Giovanna
  • gene
  • dietet

Work 1 of 1

Sorted by relevance

Conference

Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status

by Veronika Fedirko; Mazda Jenab; Catherine Meplan; Jeb Jones; Wanzhe Zhu; Lutz Schomburg; Afshan Siddiq; Sandra Hybsier; Kim Overvad; Anne Tjonneland; Hanane Omichessan; Vittorio Perduca; Marie-Christine Boutron-Ruault; Tilman Kuehn; Verena Katzke; Krasimira Aleksandrova; Antonia Trichopoulou; Anna Karakatsani; Anastasia Kotanidou; Rosario Tumino; Salvatore Panico; Giovanna Masala; Claudia Agnoli; Alessio Naccarati; Bas Bueno-de-Mesquita; Roel C.H. Vermeulen; Elisabete Weiderpass; Guri Skeie; Therese Haugdahl Nost; Leila Lujan-Barroso; J. Ramon Quiros; Jose Maria Huerta; Miguel Rodriguez-Barranco; Aurelio Barricarte; Bjorn Gylling; Sophia Harlid; Kathryn E. Bradbury; Nick Wareham; Kay-Tee Khaw; Marc Gunter; Neil Murphy; Heinz Freisling; Kostas Tsilidis; Dagfinn Aune; Elio Riboli; John E. Hesketh; David J. Hughes

2019-04-01

Subjects
  • Health Sciences, Epidemiology
  • Health Sciences, Oncology
  • Health Sciences, Nutrition
  • File Download
  • View Abstract

Abstract:Close

Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengate assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P < 0.1). SNPs in Wingless/Integrated (Wnt) and Transforming growth factor (TGF) beta-signaling genes (FRZB, SMAD3, SMAD7) from pathways affected by Se intake were also associated with CRC risk after multiple testing adjustments. Interactions with Se status (using existing serum Se and Selenoprotein P data) were tested at the SNP, gene, and pathway levels. Pathway analyses using the modified Adaptive Rank Truncated Product method suggested that genes and gene x Se status interactions in antioxidant, apoptosis, and TGF-beta signaling pathways may be associated with CRC risk. This study suggests that SNPs in the Se pathway alone or in combination with suboptimal Se status may contribute to CRC development.
Site Statistics
  • 16,862
  • Total Works
  • 3,646,213
  • Downloads
  • 1,122,124
  • Downloads This Year
  • 6,807
  • Faculty Profiles

Copyright © 2016 Emory University - All Rights Reserved
540 Asbury Circle, Atlanta, GA 30322-2870
(404) 727-6861
Privacy Policy | Terms & Conditions

v2.2.8-dev

Contact Us Recent and Popular Items
Download now