Skip to navigation Skip to content
  • Woodruff
  • Business
  • Health Sciences
  • Law
  • Rose
  • Oxford College
  • Theology
  • Schools
    • Undergraduate

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing

      Community

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing
    • Graduate

      • Business School
      • Graduate School
      • School of Law
      • School of Medicine
      • School of Nursing
      • School of Public Health
      • School of Theology
  • Libraries
    • Libraries

      • Robert W. Woodruff
      • Business
      • Chemistry
      • Health Sciences
      • Law
      • MARBL
      • Music & Media
      • Oxford College
      • Theology
    • Library Tools

      • Course Reserves
      • Databases
      • Digital Scholarship (ECDS)
      • discoverE
      • eJournals
      • Electronic Dissertations
      • EmoryFindingAids
      • EUCLID
      • ILLiad
      • OpenEmory
      • Research Guides
  • Resources
    • Resources

      • Administrative Offices
      • Emory Healthcare
      • Academic Calendars
      • Bookstore
      • Campus Maps
      • Shuttles and Parking
      • Athletics: Emory Eagles
      • Arts at Emory
      • Michael C. Carlos Museum
      • Emory News Center
      • Emory Report
    • Resources

      • Emergency Contacts
      • Information Technology (IT)
      • Outlook Web Access
      • Office 365
      • Blackboard
      • OPUS
      • PeopleSoft Financials: Compass
      • Careers
      • Human Resources
      • Emory Alumni Association
  • Browse
    • Works by Author
    • Works by Journal
    • Works by Subject
  • For Authors
    • How to Submit
    • Deposit Advice
    • Deposit Instructions
    • Author Rights
    • FAQ
    • Emory Open Access Policy
    • Open Access Fund
  • About OpenEmory
    • About OpenEmory
    • About Us
    • Citing Articles
    • Contact Us
    • Privacy Policy
    • Terms of Use
 
Contact Us

Filter Results:

Year

  • 2021 (81)
  • 2020 (65)
  • 2019 (56)
  • 2022 (49)
  • 2017 (47)
  • 2018 (44)
  • 2016 (40)
  • 2012 (39)
  • 2014 (39)
  • 2023 (29)
  • 2013 (26)
  • 2015 (20)
  • 2011 (11)
  • 2009 (8)
  • 2010 (6)
  • 2008 (4)
  • 2007 (3)
  • 2006 (2)
  • 2004 (1)

Author

  • Clifford, Gari (27)
  • Yoganathan, Ajit (23)
  • Fei, Baowei (21)
  • Yang, Xiaofeng (19)
  • Davis, Michael (17)
  • Liu, Tian (17)
  • Lei, Yang (16)
  • Boyan, Barbara (15)
  • Wang, Tonghe (15)
  • Nemati, Shamim (14)
  • Schwartz, Zvi (14)
  • Serpooshan, Vahid (14)
  • McDevitt, Todd (13)
  • Halicek, Martin (12)
  • Jo, Hanjoong (12)
  • Kong, Jun (12)
  • Mao, Hui (11)
  • Willett, Nick (11)
  • Curran Jr, Walter (10)
  • Li, Qiao (10)
  • Shah, Amit (10)
  • Lam, Wilbur (9)
  • Wang, Dongmei (9)
  • Wang, Fusheng (8)
  • Xia, Younan (8)
  • Xu, Chunhui (8)
  • Chen, Amy (7)
  • Clifford, Gari D. (7)
  • Guldberg, Robert E. (7)
  • Liu, Chengyu (7)
  • Maxwell, Joshua (7)
  • Oshinski, John (7)
  • Patel, Pretesh (7)
  • Ting, Lena (7)
  • Botchwey, Edward (6)
  • Clasen, Thomas (6)
  • Emelianov, Stanislav (6)
  • Giddens, Don (6)
  • Jha, Rajneesh (6)
  • Ning, Liqun (6)
  • Olivares-Navarrete, Rene (6)
  • Sun, Wei (6)
  • Teodoro, George (6)
  • Wagner, Mary (6)
  • Barker, Thomas (5)
  • Bheri, Sruti (5)
  • Boopathy, Archana V. (5)
  • Field-Fote, Edelle (5)
  • Fu, Yabo (5)
  • Galipeau, Jacques (5)
  • Hettiaratchi, Marian H. (5)
  • Higgins, Kristin (5)
  • Jin, Peng (5)
  • Park, Hyun-Ji (5)
  • Prausnitz, Mark (5)
  • Reinertsen, Erik (5)
  • Samady, Habib (5)
  • Sarnat, Jeremy (5)
  • Shahedi, Maysam (5)
  • Sharma, Ashish (5)
  • Tang, Dalin (5)
  • Theus, Andrea S. (5)
  • Tomov, Martin L. (5)
  • Wen, Zhexing (5)
  • Xue, Jiajia (5)
  • Bao, Gang (4)
  • Bauser-Heaton, Holly (4)
  • Boulis, Nicholas (4)
  • Bradley, Jeffrey (4)
  • Brat, Daniel (4)
  • Brown, Joe (4)
  • Brown, Milton (4)
  • Dong, Xue (4)
  • Ethier, Christopher (4)
  • Fogel, Mark A. (4)
  • Garcia, Andres J. (4)
  • Gittens, Rolando A. (4)
  • Goudy, Steven (4)
  • Guo, Xiaoya (4)
  • Jani, Ashesh (4)
  • Kathiravelu, Pradeeban (4)
  • Kim, Yun-Soung (4)
  • Kurc, Tahsin (4)
  • Kwon, Shinjae (4)
  • Levy, Karen (4)
  • Li, Yujing (4)
  • Little III, James (4)
  • Ma, Ling (4)
  • Maehara, Akiko (4)
  • Maher, Kevin (4)
  • Mark, Roger G. (4)
  • Marzbanrad, Faezeh (4)
  • McDevitt, Todd C. (4)
  • Myers, David (4)
  • Nye, Jonathon (4)
  • Padala, Muralidhar (4)
  • Paden, Matthew (4)
  • Pierce, Eric L. (4)
  • Platt, Manu Omar (4)
  • Raman, Lakshmi (4)

Subject

  • Engineering, Biomedical (339)
  • Health Sciences, Medicine and Surgery (127)
  • Biology, Cell (78)
  • Health Sciences, Radiology (54)
  • Health Sciences, Oncology (48)
  • Biology, Neuroscience (41)
  • Health Sciences, Public Health (35)
  • Chemistry, Biochemistry (34)
  • Biology, Genetics (26)
  • Health Sciences, Epidemiology (26)
  • Computer Science (25)
  • Health Sciences, General (25)
  • Engineering, Mechanical (22)
  • Health Sciences, Pathology (22)
  • Biology, Molecular (19)
  • Health Sciences, Immunology (19)
  • Biology, Microbiology (18)
  • Environmental Sciences (17)
  • Health Sciences, Rehabilitation and Therapy (17)
  • Biology, Bioinformatics (16)
  • Chemistry, General (15)
  • Biophysics, Medical (14)
  • Biology, Biostatistics (13)
  • Biology, Physiology (10)
  • Engineering, Environmental (10)
  • Engineering, Chemical (9)
  • Health Sciences, Pharmacology (8)
  • Engineering, Electronics and Electrical (7)
  • Health Sciences, Opthamology (7)
  • Mathematics (7)
  • Biophysics, General (6)
  • Education, Technology (6)
  • Engineering, General (5)
  • Health Sciences, Human Development (5)
  • Physics, Optics (5)
  • Biology, Anatomy (4)
  • Biology, General (4)
  • Biology, Radiation (4)
  • Health Sciences, Health Care Management (4)
  • Engineering, Materials Science (3)
  • Health Sciences, Obstetrics and Gynecology (3)
  • Biology, Plant Physiology (2)
  • Biology, Virology (2)
  • Engineering, Civil (2)
  • Geography (2)
  • Health Sciences, Mental Health (2)
  • Health Sciences, Nursing (2)
  • Health Sciences, Occupational Health and Safety (2)
  • Health Sciences, Pharmacy (2)
  • Physics, Acoustics (2)
  • Physics, Atmospheric Science (2)
  • Physics, General (2)
  • Anthropology, Archaeology (1)
  • Anthropology, Cultural (1)
  • Applied Mechanics (1)
  • Biology, Veterinary Science (1)
  • Biology, Zoology (1)
  • Chemistry, Analytical (1)
  • Education, Philosophy of (1)
  • Engineering, Aerospace (1)
  • Engineering, Industrial (1)
  • Engineering, Nuclear (1)
  • Engineering, Robotics (1)
  • Engineering, System Science (1)
  • Gender Studies (1)
  • Geology (1)
  • Health Sciences, Audiology (1)
  • Health Sciences, Dentistry (1)
  • Health Sciences, Nutrition (1)
  • Health Sciences, Toxicology (1)
  • Information Science (1)
  • Mass Communications (1)
  • Physics, Molecular (1)
  • Psychology, General (1)
  • Psychology, Psychobiology (1)
  • Psychology, Social (1)
  • Sociology, General (1)
  • Statistics (1)

Journal

  • Biomaterials (27)
  • Acta Biomaterialia (19)
  • Annals of Biomedical Engineering (18)
  • PHYSIOLOGICAL MEASUREMENT (15)
  • PHYSICS IN MEDICINE AND BIOLOGY (14)
  • SENSORS (14)
  • Journal of Biomechanics (13)
  • STEM CELLS (10)
  • Cell Stem Cell (9)
  • ENVIRONMENTAL SCIENCE & TECHNOLOGY (9)
  • Physics in Medicine and Biology (9)
  • Physiological Measurement (9)
  • Scientific Reports (9)
  • Stem Cells Translational Medicine (9)
  • BIOMATERIALS (8)
  • Stem Cells International (8)
  • ADVANCED HEALTHCARE MATERIALS (7)
  • JOURNAL OF NEUROENGINEERING AND REHABILITATION (7)
  • Stem Cell Reports (7)
  • ACTA BIOMATERIALIA (6)
  • NATURE BIOMEDICAL ENGINEERING (6)
  • Cardiovascular Engineering and Technology (5)
  • JOURNAL OF NEURAL ENGINEERING (5)
  • ANNALS OF BIOMEDICAL ENGINEERING (4)
  • ASAIO JOURNAL (4)
  • ASAIO Journal (4)
  • CARDIOVASCULAR ENGINEERING AND TECHNOLOGY (4)
  • Cellular and Molecular Bioengineering (4)
  • Environmental Science and Technology (4)
  • IEEE ACCESS (4)
  • INDOOR AIR (4)
  • JOURNAL OF FUNCTIONAL BIOMATERIALS (4)
  • Journal of Biomedical Materials Research Part A (4)
  • Journal of Neural Engineering (4)
  • Stem Cells (4)
  • BIOENGINEERING & TRANSLATIONAL MEDICINE (3)
  • BIOMEDICAL ENGINEERING ONLINE (3)
  • BioMedical Engineering OnLine (3)
  • Biomechanics and Modeling in Mechanobiology (3)
  • CELL STEM CELL (3)
  • COMPUTERS IN BIOLOGY AND MEDICINE (3)
  • CURRENT OPINION IN BIOMEDICAL ENGINEERING (3)
  • Cell Transplantation (3)
  • ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (3)
  • FRONTIERS IN CARDIOVASCULAR MEDICINE (3)
  • International Journal for Numerical Methods in Biomedical Engineering (3)
  • Journal of Biomechanical Engineering (3)
  • Journal of NeuroEngineering and Rehabilitation (3)
  • PLoS ONE (3)
  • STEM CELL REPORTS (3)
  • STEM CELLS TRANSLATIONAL MEDICINE (3)
  • Stem Cell Research and Therapy (3)
  • Theranostics (3)
  • 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (2)
  • ACS Applied Materials and Interfaces (2)
  • ACS Nano (2)
  • Advanced Healthcare Materials (2)
  • Annals of Biomedical Engineering (2)
  • BIOENGINEERING-BASEL (2)
  • BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2)
  • CYTOTHERAPY (2)
  • EUROPEAN CELLS & MATERIALS (2)
  • FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2)
  • IEEE Transactions on Biomedical Engineering (2)
  • JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2)
  • Journal for ImmunoTherapy of Cancer (2)
  • MEDICAL IMAGE ANALYSIS (2)
  • Medical Image Analysis (2)
  • Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling (2)
  • NPJ CLEAN WATER (2)
  • Nature Biomedical Engineering (2)
  • Nature Communications (2)
  • PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2)
  • Pacing and Clinical Electrophysiology (2)
  • Proceedings of SPIE (2)
  • Proceedings of the IEEE (2)
  • STEM CELL RESEARCH & THERAPY (2)
  • STEM CELLS INTERNATIONAL (2)
  • Sensors (2)
  • WATER RESEARCH (2)
  • Water Research (2)
  • 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20 (1)
  • 2011 8TH IEEE International Symposium on Biomedical Imaging: From Nano to Macro (1)
  • 2015 IEEE 12TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI) (1)
  • 2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI) (1)
  • 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (1)
  • 2018 COMPUTING IN CARDIOLOGY CONFERENCE (CINC) (1)
  • 2018 IEEE 15TH INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS (BHI) AND THE WEARABLE AND IMPLANTABLE BODY SENSOR NETWORKS (BSN) (1)
  • 2018 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2018 (1)
  • 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019) (1)
  • 2019 IEEE 43rd Annual Computer Software and Applications Conference (COMPSAC) (1)
  • 2020 IEEE 17TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2020) (1)
  • 2020 IEEE 44th Annual Computers, Software, and Applications Conference (COMPSAC) (1)
  • 2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC) (1)
  • 2021 COMPUTING IN CARDIOLOGY (CINC) (1)
  • ACS APPLIED ELECTRONIC MATERIALS (1)
  • AEROSOL SCIENCE AND TECHNOLOGY (1)
  • AIChE Journal (1)
  • ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021 (1)
  • APL BIOENGINEERING (1)

Keyword

  • scienc (513)
  • technolog (510)
  • biomed (342)
  • biomedicin (291)
  • life (291)
  • cell (211)
  • tissu (154)
  • biolog (111)
  • stem (109)
  • materi (100)
  • biomateri (99)
  • imag (94)
  • model (81)
  • medicin (79)
  • heart (70)
  • comput (67)
  • stemcel (66)
  • system (65)
  • differenti (63)
  • express (63)
  • in (63)
  • medic (61)
  • diseas (55)
  • biophys (54)
  • bone (52)
  • factor (52)
  • nuclear (52)
  • physic (50)
  • protein (50)
  • human (49)
  • radiolog (49)
  • electr (48)
  • learn (48)
  • electron (46)
  • gene (46)
  • growth (46)
  • vitro (46)
  • mesenchym (45)
  • therapi (45)
  • 2 (43)
  • invitro (43)
  • cardiac (42)
  • cancer (40)
  • deliveri (39)
  • analysi (38)
  • mechan (37)
  • activ (35)
  • deep (35)
  • network (35)
  • cardiovascular (34)
  • microbiolog (33)
  • vivo (33)
  • appli (32)
  • function (32)
  • myocardi (32)
  • stress (32)
  • biotechnolog (31)
  • environment (31)
  • physiolog (31)
  • progenitor (31)
  • segment (31)
  • topic (31)
  • infarct (30)
  • other (30)
  • regener (30)
  • endotheli (29)
  • research (29)
  • 1 (28)
  • health (28)
  • matrix (28)
  • nanoparticl (28)
  • simul (28)
  • brain (27)
  • flow (27)
  • hydrogel (27)
  • muscl (27)
  • neural (27)
  • transplant (27)
  • 3 (26)
  • dynam (26)
  • ecolog (26)
  • scaffold (26)
  • blood (25)
  • rate (25)
  • signal (25)
  • applic (24)
  • extracellular (24)
  • optic (24)
  • repair (24)
  • arteri (23)
  • control (23)
  • injuri (23)
  • marrow (23)
  • multidisciplinari (23)
  • neurolog (23)
  • risk (23)
  • cardiolog (22)
  • instrument (22)
  • interdisciplinari (22)

Author affiliation

  • Position object (168) (11)
  • Position object (169) (11)
  • Position object (100) (2)
  • Position object (103) (2)
  • Position object (107) (2)
  • Position object (56) (2)
  • Position object (57) (2)
  • Position object (58) (2)
  • Position object (77) (2)
  • Position object (112) (1)
  • Position object (113) (1)
  • Position object (114) (1)
  • Position object (133) (1)
  • Position object (151) (1)
  • Position object (239) (1)
  • Position object (240) (1)
  • Position object (241) (1)
  • Position object (242) (1)
  • Position object (44) (1)
  • Position object (45) (1)

Author department

  • BME: Admin (187)
  • BMI: Admin (61)
  • Orthopaedics: Admin (34)
  • Medicine: Cardiology (32)
  • Peds: Children's Hrt Ctr (27)
  • Environmental Health (25)
  • Rad Onc: Admin (24)
  • Rad: Physics & Comp Lab (21)
  • Pathology: Admin (19)
  • Rad: MR Research Lab (19)
  • Rehab: Admin (15)
  • Epidemiology (14)
  • Biostatistics (13)
  • Medicine: Pulmonary (13)
  • Hum Gen: Admin (11)
  • Sickle Cell (11)
  • Biochem: Admin (8)
  • HMO: Hematology (8)
  • Rad: Rsch Labs - Gen (8)
  • Surgery: Thoracic (8)
  • Academic Advancement (7)
  • Critical Care (7)
  • Neurosurgery: Admin (7)
  • Psych: Admin (7)
  • Rad: Admin (7)
  • Anesthesiology: Admin (6)
  • Cell Biology: Admin (6)
  • Chemistry (6)
  • Global Health (6)
  • HMO: BMT (6)
  • HMO: Med Onc (6)
  • Micro/Immun: Admin (6)
  • Neurology: Movement Disor (6)
  • Winship Cancer Institute (6)
  • Peds: Cystic Fibrosis (5)
  • Ophthal: Admin (4)
  • Otolaryngology (4)
  • Pharmacology: Admin (4)
  • Rad: Cardio Thoracic (4)
  • Rad: Nuclear Medicine (4)
  • Surgery: Oncology (4)
  • Surgery: Transplant (4)
  • Surgery: Vascular (4)
  • Biology (3)
  • Georgia CTSA (3)
  • Medicine: Digestive Dis (3)
  • Medicine: Infectious Dis (3)
  • Neurology: Admin (3)
  • Neurology: Sleep (3)
  • Peds: Hematology (3)
  • Peds: Sickle Cell (3)
  • Student Affairs (3)
  • BMT (2)
  • Ctr Study Human Health (2)
  • Emerg Med: Admin (2)
  • GYN OB: VCF 2nd MD (2)
  • Infectious Disease (2)
  • Leukemia Lymphoma (2)
  • Mathematics (2)
  • Medicine: Endocrinology (2)
  • Medicine: Immunology (2)
  • NND-Neuroscience (2)
  • Peds: Administration (2)
  • Peds: Infectious Disease (2)
  • Physics (2)
  • Rsch Compl & Reg. Affairs (2)
  • Surgery: Plastic (2)
  • Urology: Admin (2)
  • Application Development (1)
  • Center for Comprehensive Infor (1)
  • Computer Science (1)
  • EVP Health Affairs (1)
  • Emory Transplant Ctr (1)
  • Emory Vaccine Center (1)
  • Endocrinology (1)
  • Faculty Support / Resrch (1)
  • GDBBS MSP (1)
  • GME: Grad Medicine Educ (1)
  • GYN OB: Research (1)
  • Health Policy and Mngmnt (1)
  • Hospitalists (1)
  • Medicine: Admin (1)
  • Medicine: General Med (1)
  • Medicine: Hospital Med (1)
  • Medicine: Nephrology (1)
  • Music (1)
  • Neuro-Oncology (1)
  • Neurology: Cog Neurobehav (1)
  • Neurology: Epilepsy (1)
  • Neurology: Neuro-Oncology (1)
  • Neurology: Neuromuscular (1)
  • Neurology: Stroke (1)
  • Otolaryngology:Admin (1)
  • Oxford College (1)
  • Peds: Allergy (1)
  • Peds: Emory LOBP (1)
  • Peds: Gastroenterology (1)
  • Peds: Gene Therapy (1)
  • Peds: General (1)
  • Peds: Hospital Medicine (1)

Search Results for all work with filters:

  • engin

Work 1-10 of 570

Sorted by relevance
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6
  7. 7
  8. ...
>

Article

Wireless, Flexible, Ion-Selective Electrode System for Selective and Repeatable Detection of Sodium

by Hyo-Ryoung Lim; Yun-Soung Kim; Shinjae Kwon; Musa Mahmood; Young-Tae Kwon; Yongkuk Lee; Soon Min Lee; Woon-Hong Yeo

2020

Subjects
  • Engineering, Biomedical
  • File Download
  • View Abstract

Abstract:Close

Wireless, flexible, ion-selective electrodes (ISEs) are of great interest in the development of wearable health monitors and clinical systems. Existing film-based electrochemical sensors, however, still have practical limitations due to poor electrical contact and material–interfacial leakage. Here, we introduce a wireless, flexible film-based system with a highly selective, stable, and reliable sodium sensor. A flexible and hydrophobic composite with carbon black and soft elastomer serves as an ion-to-electron transducer offering cost efficiency, design simplicity, and long-term stability. The sensor package demonstrates repeatable analysis of selective sodium detection in saliva with good sensitivity (56.1 mV/decade), stability (0.53 mV/h), and selectivity coefficient of sodium against potassium (−3.0). The film ISEs have an additional membrane coating that provides reinforced stability for the sensor upon mechanical bending. Collectively, the comprehensive study of materials, surface chemistry, and sensor design in this work shows the potential of the wireless flexible sensor system for low-profile wearable applications.

Article

TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma

by Maximilian O Schaettler; Rupen Desai; Anthony Z Wang; Alexandra J Livingstone; Dale K Kobayashi; Andrew T Coxon; Jay A Bowman-Kirigin; Connor J Liu; Mao Li; Diane E Bender; Michael J White; David M Kranz; Tanner M Johanns; Gavin P Dunn

2023

Subjects
  • Health Sciences, Medicine and Surgery
  • File Download
  • View Abstract

Abstract:Close

Background Adoptive cellular therapies with chimeric antigen receptor T cells have revolutionized the treatment of some malignancies but have shown limited efficacy in solid tumors such as glioblastoma and face a scarcity of safe therapeutic targets. As an alternative, T cell receptor (TCR)-engineered cellular therapy against tumor-specific neoantigens has generated significant excitement, but there exist no preclinical systems to rigorously model this approach in glioblastoma. Methods We employed single-cell PCR to isolate a TCR specific for the Imp3 D81N neoantigen (mImp3) previously identified within the murine glioblastoma model GL261. This TCR was used to generate the Mutant Imp3-Specific TCR TransgenIC (MISTIC) mouse in which all CD8 T cells are specific for mImp3. The therapeutic efficacy of neoantigen-specific T cells was assessed through a model of cellular therapy consisting of the transfer of activated MISTIC T cells and interleukin 2 into lymphodepleted tumor-bearing mice. We employed flow cytometry, single-cell RNA sequencing, and whole-exome and RNA sequencing to examine the factors underlying treatment response. Results We isolated and characterized the 3×1.1C TCR that displayed a high affinity for mImp3 but no wild-type cross-reactivity. To provide a source of mImp3-specific T cells, we generated the MISTIC mouse. In a model of adoptive cellular therapy, the infusion of activated MISTIC T cells resulted in rapid intratumoral infiltration and profound antitumor effects with long-term cures in a majority of GL261-bearing mice. The subset of mice that did not respond to the adoptive cell therapy showed evidence of retained neoantigen expression but intratumoral MISTIC T cell dysfunction. The efficacy of MISTIC T cell therapy was lost in mice bearing a tumor with heterogeneous mImp3 expression, showcasing the barriers to targeted therapy in polyclonal human tumors. Conclusions We generated and characterized the first TCR transgenic against an endogenous neoantigen within a preclinical glioma model and demonstrated the therapeutic potential of adoptively transferred neoantigen-specific T cells. The MISTIC mouse provides a powerful novel platform for basic and translational studies of antitumor T-cell responses in glioblastoma.

Article

Development of Flexible Ion-Selective Electrodes for Saliva Sodium Detection

by Hyo-Ryoung Lim; Soon M Lee; Musa Mahmood; Shinjae Kwon; Yun-Soung Kim; Yongkuk Lee; Woon-Hong Yeo

2021

Subjects
  • Engineering, Mechanical
  • Engineering, Biomedical
  • File Download
  • View Abstract

Abstract:Close

Saliva can be used for health monitoring with non-invasive wearable systems. Such devices, including electrochemical sensors, may provide a safe, fast, and cost-efficient way of detecting target ions. Although salivary ions are known to reflect those in blood, no available clinical device can detect essential ions directly from saliva. Here, we introduce an all-solid-state, flexible film sensor that allows highly accurate detection of sodium levels in saliva, comparable to those in blood. The wireless film sensor system can successfully measure sodium ions from a small volume of infants’ saliva (<400 µL), demonstrating its potential as a continuous health monitor. This study includes the structural characterization and error analysis of a carbon/elastomer-based ion-selective electrode and a reference electrode to confirm the signal reliability. The sensor, composed of a pair of the electrodes, shows good sensitivity (58.9 mV/decade) and selectivity (log K = −2.68 for potassium), along with a broad detection range of 5 × 10−5 ≈ 1 M with a low detection limit of 4.27 × 10−5 M. The simultaneous comparison between the film sensor and a commercial electrochemical sensor demonstrates the accuracy of the flexible sensor and a positive correlation in saliva-to-blood sodium levels. Collectively, the presented study shows the potential of the wireless ion-selective sensor system for a non-invasive, early disease diagnosis with saliva.

Article

Global Meta-analysis of Airborne Bacterial Communities and Associations with Anthropogenic Activities

by Xiaqing Jiang; Chunhui Wang; Jinyuan Guo; Jiaheng Hou; Xiao Guo; Haoyu Zhang; Jie Tan; Mo Li; Xin Li; Huaiqiu Zhu

2022

Subjects
  • Engineering, Biomedical
  • File Download
  • View Abstract

Abstract:Close

Airborne microbiome alterations, an emerging global health concern, have been linked to anthropogenic activities in numerous studies. However, these studies have not reached a consensus. To reveal general trends, we conducted a meta-analysis using 3226 air samples from 42 studies, including 29 samples of our own. We found that samples in anthropogenic activity-related categories showed increased microbial diversity, increased relative abundance of pathogens, increased co-occurrence network complexity, and decreased positive edge proportions in the network compared with the natural environment category. Most of the above conclusions were confirmed using the samples we collected in a particular period with restricted anthropogenic activities. Additionally, unlike most previous studies, we used 15 human-production process factors to quantitatively describe anthropogenic activities. We found that microbial richness was positively correlated with fine particulate matter concentration, NH3emissions, and agricultural land proportion and negatively correlated with the gross domestic product per capita. Airborne pathogens showed preferences for different factors, indicating potential health implications. SourceTracker analysis showed that the human body surface was a more likely source of airborne pathogens than other environments. Our results advance the understanding of relationships between anthropogenic activities and airborne bacteria and highlight the role of airborne pathogens in public health.

Article

We need to address ableism in science

by Raven J Peterson

2021

Subjects
  • Biology, Cell
  • Chemistry, Biochemistry
  • File Download
  • View Abstract

Abstract:Close

In science, technology, engineering, and mathematics (STEM) fields, disabled people remain a significantly underrepresented part of the workforce. Recent data suggests that about 20% of undergraduates in the United States have disabilities, but representation in STEM fields is consistently lower than in the general population. Of those earning STEM degrees, only about 10% of undergraduates, 6% of graduate students, and 2% of doctoral students identify as disabled. This suggests that STEM fields have difficulty recruiting and retaining disabled students, which ultimately hurts the field, because disabled scientists bring unique problem-solving perspectives and input. This essay briefly explores the ways in which ableism - prejudice against disabled people based on the assumption that they are "less than"their nondisabled peers - in research contributes to the exclusion of disabled scientists and suggests ways in which the scientific community can improve accessibility and promote the inclusion of disabled scientists in academic science.

Article

Do inequalities exist in housing and working conditions among local and migrant industrial workers in Vietnam? Results from a multi-site survey

by Ngoc Do Ha; Milkie Vu; Anh Tuan Nguyen; Quynh Thi Nguyen Hoa; Phuong Bui Thanh; Van Nguyen Quy; Thu Thi Tran Ngan; Bac Thi La Ly; Thu Thi Nguyen Nga; Quang N Nguyen; Thanh Phan Hai; Thi Hoang Men; Gia Vu Linh; Minh Thi Vu Thuc; Xuan Tran Bach; Carl A Latkin; Cyrus SH Ho; Roger CM Ho

2021

Subjects
  • Health Sciences, Medicine and Surgery
  • Health Sciences, Public Health
  • File Download
  • View Abstract

Abstract:Close

Background: While internal migrants in Vietnam have been a key driving force in the country's rapid economic development, they also face many vulnerabilities. Our study seeks to explore possible inequalities in housing and working conditions between local and internal migrant industrial workers in Vietnam. Methods: Cross-sectional surveys were conducted with 1200 industrial workers in four regions of Vietnam. Dependent variables included housing conditions (satisfaction with convenience of accommodation, sanitation and water of accommodation, and accommodation in general) and working conditions (satisfaction with income, monthly income, number of hazardous working conditions, and work-related stress measured through the modified Effort-Reward Imbalance Questionnaire). The primary independent variable is migrant status. Covariates included region, gender, education, marital status, accommodation status, living arrangements, industry, age, monthly income, experience, and working hours. Results: Of the sample, 24.7% (n = 296) were migrants. Overall, no differences were found regarding housing conditions by migrant status. In adjusted regression models, migrants reported higher numbers of hazardous working conditions (β = 0.07, 95 %CI = 0.01–0.13, p = 0.01) and higher monthly income (β = 0.05, 95 %CI = 0.01–0.09, p = 0.02). Discussion: Recent state-level changes in the Vietnamese household registration system may explain the lack of differences in housing conditions by migrant status. Future research should utilize longitudinal designs to examine impacts over time of state policy on migrants’ housing conditions as well as well-being. Regarding working conditions, findings highlight the need for stronger social protection policy and better information channels on occupational health and safety for migrants. Further research, including qualitative studies, is needed to explore why migrants face more hazardous working conditions.

Conference

DEVELOPMENT OF A NOVEL 2D COLOR MAP FOR INTERACTIVE SEGMENTATION OF HISTOLOGICAL IMAGES

by Qaiser Chaudry; Yachna Sharma; Syed H. Raza; Dongmei Wang

2012-07-12

Subjects
  • Engineering, Biomedical
  • File Download
  • View Abstract

Abstract:Close

We present a color segmentation approach based on a two-dimensional color map derived from the input image. Pathologists stain tissue biopsies with various colored dyes to see the expression of biomarkers. In these images, because of color variation due to inconsistencies in experimental procedures and lighting conditions, the segmentation used to analyze biological features is usually ad-hoc. Many algorithms like K-means use a single metric to segment the image into different color classes and rarely provide users with powerful color control. Our 2D color map interactive segmentation technique based on human color perception information and the color distribution of the input image, enables user control without noticeable delay. Our methodology works for different staining types and different types of cancer tissue images. Our proposed method's results show good accuracy with low response and computational time making it a feasible method for user interactive applications involving segmentation of histological images.

Conference

AUTOMATED CELL COUNTING AND CLUSTER SEGMENTATION USING CONCAVITY DETECTION AND ELLIPSE FITTING TECHNIQUES

by Sonal Kothari; Qaiser Chaudry; Dongmei Wang

2009-08-07

Subjects
  • Engineering, Biomedical
  • File Download
  • View Abstract

Abstract:Close

This paper presents a novel, fast and semi-automatic method for accurate cell cluster segmentation and cell counting of digital tissue image samples. In pathological conditions, complex cell clusters are a prominent feature in tissue samples. Segmentation of these clusters is a major challenge for development of an accurate cell counting methodology. We address the issue of cluster segmentation by following a three step process. The first step involves pre-processing required to obtain the appropriate nuclei cluster boundary image from the RGB tissue samples. The second step involves concavity detection at the edge of a cluster to find the points of overlap between two nuclei. The third step involves segmentation at these concavities by using an ellipse-fitting technique. Once the clusters are segmented, individual nuclei are counted to give the cell count. The method was tested on four different types of cancerous tissue samples and shows promising results with a low percentage error, high true positive rate and low false discovery rate.

Article

Providing “a beam of light to see the gaps”: determinants of implementation of the Systems Analysis and Improvement Approach applied to the pediatric and adolescent HIV cascade in Kenya

by Kristin Beima-Sofie; Anjuli D Wagner; Caroline Soi; Wenjia Liu; Deanna Tollefson; Irene N Njuguna; Emily Ogutu; Douglas Gaitho; Nancy Mburu; Geoffrey Oluoch; Peter Mwaura; Peter Cherutich; Laura Oyiengo; Grace C John-Stewart; Ruth Nduati; Kenneth Sherr; Sarah Gimbel

2022

Subjects
  • Health Sciences, Epidemiology
  • Health Sciences, Medicine and Surgery
  • File Download
  • View Abstract

Abstract:Close

Background Children and adolescents living with HIV have poorer rates of HIV testing, treatment, and virologic suppression than adults. Strategies that use a systems approach to optimize these multiple, linked steps simultaneously are critical to close these gaps. Methods The Systems Analysis and Improvement Approach (SAIA) was adapted and piloted for the pediatric and adolescent HIV care and treatment cascade (SAIA-PEDS) at 6 facilities in Kenya. SAIA-PEDS includes three tools: continuous quality improvement (CQI), flow mapping, and pediatric cascade analysis (PedCAT). A predominately qualitative evaluation utilizing focus group discussions (N = 6) and in-depth interviews (N = 19) was conducted with healthcare workers after implementation to identify determinants of implementation. Data collection and analysis were grounded in the Consolidated Framework for Implementation Research (CFIR). Results Overall, the adapted SAIA-PEDS strategy was acceptable, and the three tools complemented one another and provided a relative advantage over existing processes. The flow mapping and CQI tools were compatible with existing workflows and resonated with team priorities and goals while providing a structure for group problem solving that transcended a single department’s focus. The PedCAT was overly complex, making it difficult to use. Leadership and hierarchy were complex determinants. All teams reported supportive leadership, with some describing in detail how their leadership was engaged and enthusiastic about the SAIA-PEDS process, by providing recognition, time, and resources. Hierarchy was similarly complex: in some facilities, leadership stifled rapid innovation by insisting on approving each change, while at other facilities, leadership had strong and supportive oversight of processes, checking on the progress frequently and empowering teams to test innovative ideas. Conclusion CQI and flow mapping were core components of SAIA-PEDS, with high acceptability and consistent use, but the PedCAT was too complex. Leadership and hierarchy had a nuanced role in implementation. Future SAIA-PEDS testing should address PedCAT complexity and further explore the modifiability of leadership engagement to maximize implementation.

Article

Effect of Zinc and Nitric Oxide on Monocyte Adhesion to Endothelial Cells under Shear Stress

by Sungmun Lee; Suzanne G. Eskin; Ankit K. Shah; Lisa A. Schildmeyer; Larry McIntire

2012

Subjects
  • Engineering, Biomedical
  • File Download
  • View Abstract

Abstract:Close

This study describes the effect of zinc on monocyte adhesion to endothelial cells under different shear stress regimens, which may trigger atherogenesis. Human umbilical vein endothelial cells were exposed to steady shear stress (15 dynes/cm 2 or 1 dyne/cm 2) or reversing shear stress (time average 1 dyne/cm 2) for 24 h. In all shear stress regimes, zinc deficiency enhanced THP-1 cell adhesion, while heparinase III reduced monocyte adhesion following reversing shear stress exposure. Unlike other shear stress regimes, reversing shear stress alone enhanced monocyte adhesion, which may be associated with increased H 2O 2 and superoxide together with relatively low levels of nitric oxide (NO) production. L-N G-Nitroarginine methyl ester (L-NAME) treatment increased monocyte adhesion under 15 dynes/cm 2 and under reversing shear stress. After reversing shear stress, monocyte adhesion dramatically increased with heparinase III treatment followed by a zinc scavenger. Static culture experiments supported the reduction of monocyte adhesion by zinc following endothelial cell cytokine activation. These results suggest that endothelial cell zinc levels are important for the inhibition of monocyte adhesion to endothelial cells, and may be one of the key factors in the early stages of atherogenesis.
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6
  7. 7
  8. ...
>
Site Statistics
  • 35,724
  • Total Works
  • 9,164,124
  • Downloads
  • 241,998
  • Downloads This Year

Copyright © 2016 Emory University - All Rights Reserved
540 Asbury Circle, Atlanta, GA 30322-2870
(404) 727-6861
Privacy Policy | Terms & Conditions

v2.2.8-dev

Contact Us
Download now