Skip to navigation Skip to content
  • Woodruff
  • Business
  • Health Sciences
  • Law
  • MARBL
  • Oxford College
  • Theology
  • Schools
    • Undergraduate

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing

      Community

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing
    • Graduate

      • Business School
      • Graduate School
      • School of Law
      • School of Medicine
      • School of Nursing
      • School of Public Health
      • School of Theology
  • Libraries
    • Libraries

      • Robert W. Woodruff
      • Business
      • Chemistry
      • Health Sciences
      • Law
      • MARBL
      • Music & Media
      • Oxford College
      • Theology
    • Library Tools

      • Course Reserves
      • Databases
      • Digital Scholarship (ECDS)
      • discoverE
      • eJournals
      • Electronic Dissertations
      • EmoryFindingAids
      • EUCLID
      • ILLiad
      • OpenEmory
      • Research Guides
  • Resources
    • Resources

      • Administrative Offices
      • Emory Healthcare
      • Academic Calendars
      • Bookstore
      • Campus Maps
      • Shuttles and Parking
      • Athletics: Emory Eagles
      • Arts at Emory
      • Michael C. Carlos Museum
      • Emory News Center
      • Emory Report
    • Resources

      • Emergency Contacts
      • Information Technology (IT)
      • Outlook Web Access
      • Office 365
      • Blackboard
      • OPUS
      • PeopleSoft Financials: Compass
      • Careers
      • Human Resources
      • Emory Alumni Association
  • Browse
    • Works by Author
    • Works by Journal
    • Works by Subject
    • Works by Dept
    • Faculty by Dept
  • For Authors
    • How to Submit
    • Deposit Advice
    • Author Rights
    • Publishing Your Data
    • FAQ
    • Emory Open Access Policy
    • Open Access Fund
  • About OpenEmory
    • About OpenEmory
    • About Us
    • Citing Articles
    • Contact Us
    • Privacy Policy
    • Terms of Use
 
Contact Us

Filter Results:

Author

  • Bassell, Gary (1)
  • Singer, R.H. (1)
  • Zhang, H.L. (1)

Subject

  • Biology, Molecular (1)
  • Health Sciences, General (1)

Journal

  • Journal of Cell Biology (1)

Keyword

  • actin (1)
  • axon (1)
  • axonaltransport (1)
  • beta (1)
  • betaactin (1)
  • biolog (1)
  • biomedicin (1)
  • cell (1)
  • cone (1)
  • filopodia (1)
  • growth (1)
  • hippocamp (1)
  • hippocampalneuron (1)
  • life (1)
  • local (1)
  • m (1)
  • messeng (1)
  • messengerrna (1)
  • mrna (1)
  • neurit (1)
  • neuron (1)
  • neurotrophin (1)
  • oligodendrocyt (1)
  • outgrowth (1)
  • polar (1)
  • rna (1)
  • scienc (1)
  • signal (1)
  • signaltransduct (1)
  • subcellular (1)
  • subcellularloc (1)
  • technolog (1)
  • transduct (1)
  • transport (1)

Author department

  • Cell Biology: Admin (1)

Search Results for all work with filters:

  • 1999
  • Biology, Cell
  • cultur

Work 1 of 1

Sorted by relevance

Article

Neurotrophin regulation of beta-actin mRNA and protein localization within growth cones

by H.L. Zhang; R.H. Singer; Gary Bassell

1999

Subjects
  • Biology, Cell
  • Biology, Molecular
  • Health Sciences, General
  • File Download
  • View Abstract

Abstract:Close

Neurotrophins play an essential role in the regulation of actin- dependent changes in growth cone shape and motility. We have studied whether neurotrophin signaling can promote the localization of β-actin mRNA and protein within growth cones. The regulated localization of specific mRNAs within neuronal processes and growth cones could provide a mechanism to modulate cytoskeletal composition and growth cone dynamics during neuronal development. We have previously shown that β-actin mRNA is localized in granules that were distributed throughout processes and growth cones of cultured neurons. In this study, we demonstrate that the localization of β- actin mRNA and protein to growth cones of forebrain neurons is stimulated by neurotrophin-3 (NT-3). A similar response was observed when neurons were exposed to forskolin or db-cAMP, suggesting an involvement of a cAMP signaling pathway. NT-3 treatment resulted in a rapid and transient stimulation of PKA activity that preceded the localization of β-actin mRNA. Localization of β-actin mRNA was blocked by prior treatment of cells with Rp-cAMP, an inhibitor of cAMP-dependent protein kinase A. Depolymerization of microtubules, but not microfilaments, inhibited the NT-3-induced localization of β-actin mRNA. These results suggest that NT-3 activates a cAMP-dependent signaling mechanism to promote the microtubule-dependent localization of β- actin mRNA within growth cones.
Site Statistics
  • 16,813
  • Total Works
  • 3,638,788
  • Downloads
  • 1,114,699
  • Downloads This Year
  • 6,807
  • Faculty Profiles

Copyright © 2016 Emory University - All Rights Reserved
540 Asbury Circle, Atlanta, GA 30322-2870
(404) 727-6861
Privacy Policy | Terms & Conditions

v2.2.8-dev

Contact Us Recent and Popular Items
Download now