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Search Results for all work with filters:

  • Jinnah, Hyder
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Work 1-5 of 5

Sorted by relevance

Article

Psychiatric associations of adult-onset focal dystonia phenotypes

by Brian D. Berman; Johanna Junker; Erika Shelton; Stefan H. Sillau; Hyder Jinnah; Joel S. Perlmutter; Alberto J. Espay; Joseph Jankovic; Marie Vidailhet; Cecilia Bonnet; William Ondo; Irene A. Malaty; Ramón Rodriguez; William McDonald; Laura Marsh; Mateusz Zurowski; Tobias Baumer; Norbert Bruggemann

2017

Subjects
  • Biology, Neuroscience
  • Biology, Genetics
  • Psychology, Behavioral
  • File Download
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Abstract:Close

Background Depression and anxiety frequently accompany the motor manifestations of isolated adult-onset focal dystonias. Whether the body region affected when this type of dystonia first presents is associated with the severity of these neuropsychiatric symptoms is unknown. Objectives The aim of this study was to determine whether depression, anxiety and social anxiety vary by dystonia onset site and evaluate whether pain and dystonia severity account for any differences. Methods patients with isolated focal dystonia evaluated within 5 years from symptom onset, enrolled in the Natural history project of the Dystonia coalition, were included in the analysis. Individual onset sites were grouped into five body regions: cervical, laryngeal, limb, lower cranial and upper cranial. Neuropsychiatric symptoms were rated using the Beck Depression Inventory, hospital anxiety and Depression scale and Liebowitz social anxiety scale. pain was estimated using the 36-Item short Form survey. results Four hundred and seventy-eight subjects met our inclusion criteria. high levels of depression, anxiety and social anxiety occurred in all groups; however, the severity of anxiety and social anxiety symptoms varied by onset site group. The most pronounced differences were higher anxiety in cervical and laryngeal, lower anxiety in upper cranial and higher social anxiety in laryngeal. Increases in pain were associated with worse neuropsychiatric symptom scores within all groups. higher anxiety and social anxiety in laryngeal and lower anxiety in upper cranial persisted after correcting for pain and dystonia severity. Conclusion anxiety and social anxiety severity vary by onset site of focal dystonia, and this variation is not explained by differences in pain and dystonia severity.

Article

Oscillatory head movements in cervical dystonia: Dystonia, tremor, or both?

by Aasef Shaikh; David S. Zee; Hyder Jinnah

2015

Subjects
  • Biology, Neuroscience
  • Health Sciences, General
  • Health Sciences, Medicine and Surgery
  • File Download
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Abstract:Close

Cervical dystonia is characterized by abnormal posturing of the head, often combined with tremor-like oscillatory head movements. The nature and source of these oscillatory head movements is controversial, so they were quantified to delineate their characteristics and develop a hypothetical model for their genesis. A magnetic search coil system was used to measure head movements in 14 subjects with cervical dystonia. Two distinct types of oscillatory head movements were detected for most subjects, even when they were not clinically evident. One type had a relatively large amplitude and jerky irregular pattern, and the other had smaller amplitude with a more regular and sinusoidal pattern. The kinematic properties of these two types of oscillatory head movements were distinct, although both were often combined in the same subject. Both had features suggestive of a defect in a central neural integrator. The combination of different types of oscillatory head movements in cervical dystonia helps to clarify some of the current debates regarding whether they should be considered as manifestations of dystonia or tremor and provides novel insights into their potential pathogenesis.

Article

A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia

by Cecília N. Prudente; Randall Stilla; Shivangi Singh; Cathrin Buetefisch; Marian Evatt; Stewart Factor; Alan Freeman; Xiaoping Hu; Ellen Hess; Krishnankutty Sathian; Hyder Jinnah

2016

Subjects
  • Biology, Neuroscience
  • Health Sciences, Radiology
  • File Download
  • View Abstract

Abstract:Close

Cervical dystonia (CD) is a neurological disorder characterized by abnormal movements and postures of the head. The brain regions responsible for these abnormal movements are not well understood, because most imaging techniques for assessing regional brain activity cannot be used when the head is moving. Recently, we mapped brain activation in healthy individuals using functional magnetic resonance imaging during isometric head rotation, when muscle contractions occur without actual head movements. In the current study, we used the same methods to explore the neural substrates for head movements in subjects with CD who had predominantly rotational abnormalities (torticollis). Isometric wrist extension was examined for comparison. Electromyography of neck and hand muscles ensured compliance with tasks during scanning, and any head motion was measured and corrected. Data were analyzed in three steps. First, we conducted within-group analyses to examine task-related activation patterns separately in subjects with CD and in healthy controls. Next, we directly compared task-related activation patterns between participants with CD and controls. Finally, considering that the abnormal head movements in CD occur in a consistently patterned direction for each individual, we conducted exploratory analyses that involved normalizing data according to the direction of rotational CD. The between-group comparisons failed to reveal any significant differences, but the normalization procedure in subjects with CD revealed that isometric head rotation in the direction of dystonic head rotation was associated with more activation in the ipsilateral anterior cerebellum, whereas isometric head rotation in the opposite direction was associated with more activity in sensorimotor cortex. These findings suggest that the cerebellum contributes to abnormal head rotation in CD, whereas regions in the cerebral cortex are involved in opposing the involuntary movements.

Article

Clinical and Demographic Characteristics Related to Onset Site and Spread of Cervical Dystonia

by Scott A. Norris; Hyder Jinnah; Alberto J. Espay; Christine Klein; Norbert Brueggemann; Richard L. Barbano; Irene Malaty; Ramon L. Rodriguez; Marie Vidailhet; Emmanuel Roze; Stephen G. Reich; Brian D. Berman; Mark S. LeDoux; Sarah Pirio Richardson; Pinky Agarwal; Zoftan Mari; William Ondo; Ludy C. Shih; Susan Fox; Alfredo Berardelli; Claudia M. Testa; Florence C.F. Cheng; Daniel Truong; Fatta Nahab; Tao Xie; Mark Hallett; Ami Rosen; Laura J. Wright; J.S. Perlmutter

2016

Subjects
  • Biology, Neuroscience
  • Biology, Genetics
  • File Download
  • View Abstract

Abstract:Close

Background: Clinical characteristics of isolated idiopathic cervical dystonia such as onset site and spread to and from additional body regions have been addressed in single-site studies with limited data and incomplete or variable dissociation of focal and segmental subtypes. The objectives of this study were to characterize the clinical characteristics and demographics of isolated idiopathic cervical dystonia in the largest standardized multicenter cohort. Methods: The Dystonia Coalition, through a consortium of 37 recruiting sites in North America, Europe, and Australia, recruited 1477 participants with focal (60.7%) or segmental (39.3%) cervical dystonia on examination. Clinical and demographic characteristics were evaluated in terms of the body region of dystonia onset and spread. Results: Site of dystonia onset was: (1) focal neck only (78.5%), (2) focal onset elsewhere with later segmental spread to neck (13.3%), and (3) segmental onset with initial neck involvement (8.2%). Frequency of spread from focal cervical to segmental dystonia (22.8%) was consistent with prior reports, but frequency of segmental onset with initial neck involvement was substantially higher than the 3% previously reported. Cervical dystonia with focal neck onset, more than other subtypes, was associated with spread and tremor of any type. Sensory tricks were less frequent in cervical dystonia with segmental components, and segmental cervical onset occurred at an older age. Conclusions: Subgroups had modest but significant differences in the clinical characteristics that may represent different clinical entities or pathophysiologic subtypes. These findings are critical for design and implementation of studies to describe, treat, or modify disease progression in idiopathic isolated cervical dystonia. © 2016 International Parkinson and Movement Disorder Society.

Article

Diagnostic Delays in Spasmodic Dysphonia: A Call for Clinician Education

by Francis X. Creighton; Edie Hapner; Adam Klein; Ami Rosen; Hyder Jinnah; Michael Johns

2015

Subjects
  • Biology, Neuroscience
  • Health Sciences, Education
  • Health Sciences, Medicine and Surgery
  • File Download
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Abstract:Close

Purpose. Spasmodic dysphonia (SD) is a rare but often debilitating disease. Due to lack of awareness among practitioners and lack of well-defined diagnostic criteria, it can be difficult for patients with SD to receive a diagnosis and subsequent treatment. There is currently no literature documenting the efficacy of the medical community in recognizing and diagnosing this disorder. We aimed to quantify the patients' experiences with obtaining a diagnosis of SD. Methods. One hundred seven consecutive patients with SD completed questionnaires about their experiences with SD. Patients were recruited either during outpatient laryngology visits or during participation in a National Institutes of Health funded study investigating SD. Results. It took patients an average of 4.43 years (53.21 months) to be diagnosed with SD after first going to a physician with vocal symptoms. Patients had to see an average of 3.95 physicians to receive a diagnosis of SD. Patients (31.4%) had been prescribed medications other than botulinum toxin to treat their symptoms. Patients (30%) attempted alternative therapies for treatment of SD, such as chiropractor or dietary modification. Conclusions. Despite advances in diagnostic modalities in medicine, the diagnosis of SD still remains elusive. Objective criteria for the diagnosis of SD and increased clinician education are warranted to address this diagnostic delay.
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