Skip to navigation Skip to content
  • Woodruff
  • Business
  • Health Sciences
  • Law
  • MARBL
  • Oxford College
  • Theology
  • Schools
    • Undergraduate

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing

      Community

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing
    • Graduate

      • Business School
      • Graduate School
      • School of Law
      • School of Medicine
      • School of Nursing
      • School of Public Health
      • School of Theology
  • Libraries
    • Libraries

      • Robert W. Woodruff
      • Business
      • Chemistry
      • Health Sciences
      • Law
      • MARBL
      • Music & Media
      • Oxford College
      • Theology
    • Library Tools

      • Course Reserves
      • Databases
      • Digital Scholarship (ECDS)
      • discoverE
      • eJournals
      • Electronic Dissertations
      • EmoryFindingAids
      • EUCLID
      • ILLiad
      • OpenEmory
      • Research Guides
  • Resources
    • Resources

      • Administrative Offices
      • Emory Healthcare
      • Academic Calendars
      • Bookstore
      • Campus Maps
      • Shuttles and Parking
      • Athletics: Emory Eagles
      • Arts at Emory
      • Michael C. Carlos Museum
      • Emory News Center
      • Emory Report
    • Resources

      • Emergency Contacts
      • Information Technology (IT)
      • Outlook Web Access
      • Office 365
      • Blackboard
      • OPUS
      • PeopleSoft Financials: Compass
      • Careers
      • Human Resources
      • Emory Alumni Association
  • Browse
    • Works by Author
    • Works by Journal
    • Works by Subject
    • Works by Dept
    • Faculty by Dept
  • For Authors
    • How to Submit
    • Deposit Advice
    • Author Rights
    • Publishing Your Data
    • FAQ
    • Emory Open Access Policy
    • Open Access Fund
  • About OpenEmory
    • About OpenEmory
    • About Us
    • Citing Articles
    • Contact Us
    • Privacy Policy
    • Terms of Use
 
Contact Us

Filter Results:

Year

  • 2015 (1)

Author

  • Cahill, Michael E. (1)
  • Casaccia, Patrizia (1)
  • Estey, David (1)
  • Fan, Guoping (1)
  • Faull, Kym F. (1)
  • Feng, Jian (1)
  • Ferguson, Deveroux (1)
  • Huynh, Jimmy (1)
  • Jin, Peng (1)
  • Kennedy, Pamela (1)
  • Koo, JaWook (1)
  • Labonte, Benoit (1)
  • Laitman, Benjamin M. (1)
  • Le, Thuc (1)
  • Li, Yujing (1)
  • Mensah, Isaac (1)
  • Nestler, Eric J. (1)
  • Ribeiro, Efrain (1)
  • Shao, Ningyi (1)
  • Shen, Li (1)
  • Stockman, Victoria (1)
  • Szulwach, Keith E. (1)
  • Turecki, Gustavo (1)
  • Vialou, Vincent (1)
  • Zhong, Chun (1)

Subject

  • Biology, Genetics (1)
  • Biology, Neuroscience (1)

Journal

  • Nature Neuroscience (1)

Keyword

  • 5 (1)
  • accumben (1)
  • addict (1)
  • biomedicin (1)
  • delta (1)
  • deltafosb (1)
  • demethyl (1)
  • dna (1)
  • drug (1)
  • drugaddict (1)
  • express (1)
  • format (1)
  • fosb (1)
  • gene (1)
  • geneexpress (1)
  • life (1)
  • mammalian (1)
  • memori (1)
  • methylcytosin (1)
  • neurolog (1)
  • neurosci (1)
  • nucleus (1)
  • nucleusaccumben (1)
  • scienc (1)
  • technolog (1)
  • transcript (1)

Search Results for all work with filters:

  • Song, Hongjun
  • Couroussé, Thomas
  • enhanc
  • Hum Gen: Admin

Work 1 of 1

Sorted by relevance

Article

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

by Jian Feng; Ningyi Shao; Keith E. Szulwach; Vincent Vialou; Jimmy Huynh; Chun Zhong; Thuc Le; Deveroux Ferguson; Michael E. Cahill; Yujing Li; JaWook Koo; Efrain Ribeiro; Benoit Labonte; Benjamin M. Laitman; David Estey; Victoria Stockman; Pamela Kennedy; Thomas Couroussé; Isaac Mensah; Gustavo Turecki; Kym F. Faull; Hongjun Song; Guoping Fan; Patrizia Casaccia; Li Shen; Peng Jin; Eric J. Nestler

2015

Subjects
  • Biology, Neuroscience
  • Biology, Genetics
  • File Download
  • View Abstract

Abstract:Close

Ten-eleven translocation (TET) enzymes mediate the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which is enriched in brain, and its ultimate DNA demethylation. However, the influence of TET and 5hmC on gene transcription in brain remains elusive. We found that ten-eleven translocation protein 1 (TET1) was downregulated in mouse nucleus accumbens (NAc), a key brain reward structure, by repeated cocaine administration, which enhanced behavioral responses to cocaine. We then identified 5hmC induction in putative enhancers and coding regions of genes that have pivotal roles in drug addiction. Such induction of 5hmC, which occurred similarly following TET1 knockdown alone, correlated with increased expression of these genes as well as with their alternative splicing in response to cocaine administration. In addition, 5hmC alterations at certain loci persisted for at least 1 month after cocaine exposure. Together, these reveal a previously unknown epigenetic mechanism of cocaine action and provide new insight into how 5hmC regulates transcription in brain in vivo.
Site Statistics
  • 16,865
  • Total Works
  • 3,645,231
  • Downloads
  • 1,121,142
  • Downloads This Year
  • 6,807
  • Faculty Profiles

Copyright © 2016 Emory University - All Rights Reserved
540 Asbury Circle, Atlanta, GA 30322-2870
(404) 727-6861
Privacy Policy | Terms & Conditions

v2.2.8-dev

Contact Us Recent and Popular Items
Download now