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  • Agnoli, Claudia
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Article

Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations

by Franzel J.B. van Duijnhoven; Mazda Jenab; Kristian Hveem; Peter D. Siersema; Veronika Fedirko; Eric J. Duell; Ellen Kampman; Anouk Halfweeg; Henk J. van Kranen; Jody M.W. van den Ouweland; Elisabete Weiderpass; Neil Murphy; Arnulf Langhammer; Eivind Ness-Jensen; Anja Olsen; Anne Tjonneland; Kim Overvad; Claire Cadeau; Marina Kvaskoff; Marie-Christine Boutron-Ruault; Verena A. Katzke; Tilman Kuehn; Heiner Boeing; Antonia Trichopoulou; Anastasia Kotanidou; Maria Kritikou; Domenico Palli; Claudia Agnoli; Rosario Tumino; Salvatore Panico; Giuseppe Matullo; Petra Peeters; Magritt Brustad; Karina Standahl Olsen; Cristina Lasheras; Mireia Obon-Santacana; Maria-Jose Sanchez; Miren Dorronsoro; Maria-Dolores Chirlaque; Aurelio Barricarte; Jonas Manjer; Martin Almquist; Frida Renstrom; Weimin Ye; Nick Wareham; Kay-Tee Khaw; Kathryn E. Bradbury; Heinz Freisling; Dagfinn Aune; Teresa Norat; Elio Riboli; H. B(as) Bueno-de-Mesquita

2018

Subjects
  • Health Sciences, Epidemiology
  • Health Sciences, Public Health
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Abstract:Close

Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D 2 and 25(OH)D 3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of > 50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42–1.20); 0.94 (0.72–1.22); 1.12 (0.82–1.53) and 1.26 (0.79–2.01) for clinically pre-defined categories of ≤25; > 25 to 50; > 75 to 100; and > 100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
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