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  • 2010 (1)

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  • Li, Xing-Cong
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Article

Anti-infective Discorhabdins from a Deep-Water Alaskan Sponge of the Genus Latrunculia

by MinKyun Na; Yuanqing Ding; Bin Wang; Babu L. Tekwani; Raymond F Schinazi; Scott Franzblau; Michelle Kelly; Robert Stone; Xing-Cong Li; Daneel Ferreira; Mark T. Hamann

2010

Subjects
  • Chemistry, Pharmaceutical
  • Health Sciences, Pharmacology
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Abstract:Close

Bioassay- and LC-MS-guided fractionation of a methanol extract from a new deep-water Alaskan sponge species of the genus Latrunculia resulted in the isolation of two new brominated pyrroloiminoquinones, dihydrodiscorhabdin B (1) and discorhabdin Y (2), along with six known pyrroloiminoquinone alkaloids, discorhabdins A (3), C (4), E (5), and L (6), dihydrodiscorhabdin C (7), and the benzene derivative 8. Compounds 3, 4, and 7 exhibited anti-HCV activity, antimalarial activity, and selective antimicrobial activity. Although compounds 3 and 7 displayed potent and selective in vitro antiprotozoal activity, Plasmodium berghei-infected mice did not respond to these metabolites due to their toxicity in vivo. © 2010 American Chemical Society and American Society of Pharmacognosy.
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