Skip to navigation Skip to content
  • Woodruff
  • Business
  • Health Sciences
  • Law
  • MARBL
  • Oxford College
  • Theology
  • Schools
    • Undergraduate

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing

      Community

      • Emory College
      • Oxford College
      • Business School
      • School of Nursing
    • Graduate

      • Business School
      • Graduate School
      • School of Law
      • School of Medicine
      • School of Nursing
      • School of Public Health
      • School of Theology
  • Libraries
    • Libraries

      • Robert W. Woodruff
      • Business
      • Chemistry
      • Health Sciences
      • Law
      • MARBL
      • Music & Media
      • Oxford College
      • Theology
    • Library Tools

      • Course Reserves
      • Databases
      • Digital Scholarship (ECDS)
      • discoverE
      • eJournals
      • Electronic Dissertations
      • EmoryFindingAids
      • EUCLID
      • ILLiad
      • OpenEmory
      • Research Guides
  • Resources
    • Resources

      • Administrative Offices
      • Emory Healthcare
      • Academic Calendars
      • Bookstore
      • Campus Maps
      • Shuttles and Parking
      • Athletics: Emory Eagles
      • Arts at Emory
      • Michael C. Carlos Museum
      • Emory News Center
      • Emory Report
    • Resources

      • Emergency Contacts
      • Information Technology (IT)
      • Outlook Web Access
      • Office 365
      • Blackboard
      • OPUS
      • PeopleSoft Financials: Compass
      • Careers
      • Human Resources
      • Emory Alumni Association
  • Browse
    • Works by Author
    • Works by Journal
    • Works by Subject
    • Works by Dept
    • Faculty by Dept
  • For Authors
    • How to Submit
    • Deposit Advice
    • Author Rights
    • Publishing Your Data
    • FAQ
    • Emory Open Access Policy
    • Open Access Fund
  • About OpenEmory
    • About OpenEmory
    • About Us
    • Citing Articles
    • Contact Us
    • Privacy Policy
    • Terms of Use
 
Contact Us

Filter Results:

Year

  • 2014 (1)

Author

  • Agudo, Antonio (1)
  • Bamia, Christina (1)
  • Barricarte, Aurelio (1)
  • Benetou, Vassiliki (1)
  • Boeing, Heiner (1)
  • Boffetta, Paolo (1)
  • Boutron-Ruault, Marie-Christine (1)
  • Bueno-De-Mesquita, Bas (1)
  • Dorronsoro, Miren (1)
  • Dossus, Laure (1)
  • Duarte-Salles, Talita (1)
  • Fedirko, Veronika (1)
  • Gavrila, Diana (1)
  • Gram, Inger Torhild (1)
  • Halkjær, Jytte (1)
  • Jenab, Mazda (1)
  • Johansson, Anders (1)
  • Kaaks, Rudolf (1)
  • Khaw, Kay-Tee (1)
  • Lagiou, Pagona (1)
  • Lindkvist, Björn (1)
  • Lukanova, Annekatrin (1)
  • Lund, Eiliv (1)
  • Ohlsson, Bodil (1)
  • Overvad, Kim (1)
  • Palli, Domenico (1)
  • Panico, Salvatore (1)
  • Peeters, Petra H (1)
  • Pischon, Tobias (1)
  • Quirós, J Ramón (1)
  • Racine, Antoine (1)
  • Stepien, Magdalena (1)
  • Sund, Malin (1)
  • Sánchez, María-José (1)
  • Tjønneland, Anne (1)
  • Travis, Ruth C (1)
  • Trepo, Elisabeth (1)
  • Trichopoulos, Dimitrios (1)
  • Trichopoulou, Antonia (1)
  • Tumino, Rosario (1)
  • Vineis, Paolo (1)
  • Wareham, Nicholas (1)
  • Weiderpass, Elisabete (1)
  • Westhpal, Sabine (1)

Subject

  • Health Sciences, Epidemiology (1)
  • Health Sciences, Public Health (1)

Journal

  • Hepatology (1)

Keyword

  • 6 (1)
  • adiponectin (1)
  • biomedicin (1)
  • c (1)
  • cancer (1)
  • carcinoma (1)
  • chronic (1)
  • colorect (1)
  • colorectalcanc (1)
  • diseas (1)
  • gastroenterolog (1)
  • hepat (1)
  • hepatitisc (1)
  • hepatocellular (1)
  • hepatocellularcarcinoma (1)
  • hepatolog (1)
  • insulin (1)
  • insulinresist (1)
  • interleukin (1)
  • leptin (1)
  • life (1)
  • model (1)
  • obes (1)
  • resist (1)
  • risk (1)
  • scienc (1)
  • technolog (1)

Author affiliation

  • Winship Cancer Institute (1)

Author department

  • Epidemiology (1)

Search Results for all work with filters:

  • Agnoli, Claudia
  • Aleksandrova, Krasimira
  • Nöthlings, Ute
  • Riboli, Elio

Work 1 of 1

Sorted by relevance

Article

Inflammatory and Metabolic Biomarkers and Risk of Liver and Biliary Tract Cancer

by Krasimira Aleksandrova; Heiner Boeing; Ute Nöthlings; Mazda Jenab; Veronika Fedirko; Rudolf Kaaks; Annekatrin Lukanova; Antonia Trichopoulou; Dimitrios Trichopoulos; Paolo Boffetta; Elisabeth Trepo; Sabine Westhpal; Talita Duarte-Salles; Magdalena Stepien; Kim Overvad; Anne Tjønneland; Jytte Halkjær; Marie-Christine Boutron-Ruault; Laure Dossus; Antoine Racine; Pagona Lagiou; Christina Bamia; Vassiliki Benetou; Claudia Agnoli; Domenico Palli; Salvatore Panico; Rosario Tumino; Paolo Vineis; Bas Bueno-De-Mesquita; Petra H Peeters; Inger Torhild Gram; Eiliv Lund; Elisabete Weiderpass; J Ramón Quirós; Antonio Agudo; María-José Sánchez; Diana Gavrila; Aurelio Barricarte; Miren Dorronsoro; Bodil Ohlsson; Björn Lindkvist; Anders Johansson; Malin Sund; Kay-Tee Khaw; Nicholas Wareham; Ruth C Travis; Elio Riboli; Tobias Pischon

2014

Subjects
  • Health Sciences, Epidemiology
  • Health Sciences, Public Health
  • File Download
  • View Abstract

Abstract:Close

Obesity and associated metabolic disorders have been implicated in liver carcinogenesis; however, there are little data on the role of obesity-related biomarkers on liver cancer risk. We studied prospectively the association of inflammatory and metabolic biomarkers with risks of hepatocellular carcinoma (HCC), intrahepatic bile duct (IBD), and gallbladder and biliary tract cancers outside of the liver (GBTC) in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. Over an average of 7.7 years, 296 participants developed HCC (n=125), GBTC (n=137), or IBD (n=34). Using risk-set sampling, controls were selected in a 2:1 ratio and matched for recruitment center, age, sex, fasting status, and time of blood collection. Baseline serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), C-peptide, total high-molecular-weight (HMW) adiponectin, leptin, fetuin-a, and glutamatdehydrogenase (GLDH) were measured, and incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. After adjustment for lifestyle factors, diabetes, hepatitis infection, and adiposity measures, higher concentrations of CRP, IL-6, C-peptide, and non-HMW adiponectin were associated with higher risk of HCC (IRR per doubling of concentrations=1.22; 95% CI=1.02-1.46; P = 0.03; 1.90; 95% CI=1.30-2.77; P = 0.001; 2.25; 95% CI=1.43-3.54; P = 0.0005; and 2.09; 95% CI=1.19-3.67; P = 0.01, respectively). CRP was associated also with risk of GBTC (IRR=1.22; 95% CI=1.05-1.42; P = 0.01). GLDH was associated with risks of HCC (IRR=1.62; 95% CI=1.25-2.11; P = 0.0003) and IBD (IRR=10.5; 95% CI=2.20-50.90; P = 0.003). The continuous net reclassification index was 0.63 for CRP, IL-6, C-peptide, and non-HMW adiponectin and 0.46 for GLDH, indicating good predictive ability of these biomarkers. Conclusion: Elevated levels of biomarkers of inflammation and hyperinsulinemia are associated with a higher risk of HCC, independent of obesity and established liver cancer risk factors.
Site Statistics
  • 16,876
  • Total Works
  • 3,653,757
  • Downloads
  • 1,129,668
  • Downloads This Year
  • 6,807
  • Faculty Profiles

Copyright © 2016 Emory University - All Rights Reserved
540 Asbury Circle, Atlanta, GA 30322-2870
(404) 727-6861
Privacy Policy | Terms & Conditions

v2.2.8-dev

Contact Us Recent and Popular Items
Download now