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Correspondence: Claudio Sorio, claudio.sorio@univr.it
Acknowledgements: The authors wish to acknowledge the role of the former Director of the Cystic Fibrosis Center, Verona, Italy, Prof. Baroukh Maurice Assael, for having shared and supported the initial phases of the project. We thank Martina Gentzsch (University of North Carolina – Chapel Hill) and Cystic Fibrosis Foundation for the antibodies anti-CFTR received through CFTR antibody distribution program. We also wish to thank Dr. Giulio Innamorati, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, 37134 Verona, Italy for access to EVOS FL system. We dedicate this work to H. R. DeJonge (Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam 3015, Netherlands) that was supported with his enthusiasm and criticism in this study; he regretfully passed away on June 6th, 2022 leaving a great loss in the CF community worldwide.
Author contributions: Conceptualization, P.M. and C.S.; methodology, A.F., K.K., V.L., F.S., S.P., J.C., L.R., F.T., A.C., M.B., A.E., S.L.C., G.C., D.D.O., D.J., J.H., and E.J.S.; formal analysis, A.F., K.K., V.L., S.P., J.C., C.L., D.D.O., and C.S.; investigation, A.F., K.K., V.L., S.P., J.C., F.A., V.R.V., E.J.S., I.Z., M.L., J.H., and D.J.; resources, C.S., P.M., S.V., and A.E.; data curation, K.K., V.L., C.S., and P.M.; writing – original draft preparation, V.L. and C.S.; writing – review and editing, C.S., K.K., and P.M.; visualization, D.D.O.; supervision, C.S.; funding acquisition, C.S., P.M., F.A., M.L., and A.E. All authors read and agreed to the published version of the manuscript.
Competing interests: P.M. was paid for her expert testimony by Vertex Pharmaceuticals.
This research was funded by the Italian Cystic Fibrosis Research Foundation, grant numbers FFC #12/2018 (Delegazione FFC di Cecina e Rosignano and Delegazione FFC di Alberobello) to A.E. and M.L., #13/2018 (Delegazione FFC di Tradate Gallarate) to C.S., and #9/2020 (Delegazione FFC di Pesaro, Rivarolo Canavese e Gruppo sostegno FFC di Fidenza) to P.M.; Lega Italiana Fibrosi Cistica onlus (C.S. and P.M.); and American Cystic Fibrosis Foundation, grant number Assael08A0 (P.M.). This work was also funded by R01HL139876 (NIH) to E.J.S. The research leading to these results has received funding from the European Union - NextGenerationEU through the Italian Ministry of University and Research under PNRR - M4C2-I1.3 Project PE_00000019 “HEAL ITALIA” to A.E. CUP I83C22001830006.
© 2023 The Author(s)