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Contributions: Matea Juric: Validation, Formal analysis, Investigation, Writing – review & editing Varun Rawat: Validation, Formal analysis, Investigation, Writing – review & editing, Visualization M.J and V.R. equally contributed to this work. Radhika Amaradhi: Investigation, Writing – review & editing Jacek Zielonka: Conceptualization, Methodology, Validation, Formal analysis, Investigation, Resources, Data curation, Writing – original draft, Writing – review & editing, Visualization, Supervision, Project administration, Funding acquisition Thota Ganesh: Conceptualization, Methodology, Validation, Resources, Data curation, Writing – original draft, Writing – review & editing, Supervision, Project administration, Funding acquisition Conceptualization, T.G. and J.Z.; methodology, J.Z. and T.G.; validation, M.J., V.R., J.Z. and T.G.; formal analysis, M.J., V.R. and J.Z.; investigation, M.J., V.R., R.A. and J.Z.; resources, T.G. and J.Z.; data curation, T.G. and J.Z.; writing—original draft preparation, J.Z. and T.G.; writing—review and editing, M.J., V.R., R.A., J.Z. and T.G.; visualization, J.Z. and V.R.; supervision, J.Z. and T.G.; project administration, J.Z. and T.G.; funding acquisition, J.Z. and T.G.
Acknowledgments: J.Z. thanks B. Kalyanaraman (Medical College of Wisconsin) for providing access to the plate readers and HPLC instruments for the completion of this study.
Conflicts of Interest T.G., J.Z. and R.A. are inventors of patent application Quinazoline derivatives, pharmaceutical compositions, and therapeutic uses related to Nox inhibition (WO2022225866A1).
This work was supported by NIH/NIA grant U01 AG052460 (T.G.). The liquid handling equipment used to monitor the Nox2 inhibitory activity of the compounds tested was purchased using funds from the Advancing a Healthier Wisconsin Endowment (project 5520583: Small Volume Multi-well Plate Dispensers for Screening Drug Combinations) awarded to J.Z.
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