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Author Notes:

Sharmila Raghunandan, Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University, 1405 Clifton Rd, Atlanta, GA 30322; sraghu2@emory.edu

S.R., L.G., J.H., A.A.L., and B.W. designed the study, analyzed the data, and wrote the manuscript; and S.R., L.G., M.G., B.B., Y.S., S.G., A.L.W., K.M.W., M.L.S., L.S.K., J.H., A.A.L., M.Q., and B.W. reviewed the data and edited the manuscript.

M.L.S. reports being a consultant/receiving honorarium at Omeros and Alexion. M.Q. reports receiving honoraria at Vertex and Novartis. L.S.K. reports receiving research funding from Novartis, bluebird bio, EMD Serono, and Magenta; consultancy from Vertex and HiFiBio; patents and royalties: clinical trial, research funding from Bristol Myers Squibb; is a current equity holder in private company Mammoth Biosciences; and is a current holder of stock options in a privately held company. The remaining authors declare no competing financial interests.

Subject:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Hematology

Abatacept for the prevention of GVHD in patients receiving mismatched unrelated transplants: a real-world analysis

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Journal Title:

BLOOD ADVANCES

Volume:

Volume 7, Number 16

Publisher:

, Pages 4395-4399

Type of Work:

Article | Final Publisher PDF

Abstract:

TO THE EDITOR: Allogeneic hematopoietic cell transplantation (HCT) is paramount to the treatment of relapsed refractory hematologic malignancies. In the absence of a matched related or unrelated donor, a mismatched unrelated donor (MMUD) increases the donor options, particularly for patients from ethnic minorities. However, MMUD HCTs have historically conveyed an increased risk of severe (grade 3-4) acute graft-versus-host disease (aGVHD) and treatment-related mortality (TRM).

Copyright information:

© 2023 by The American Society of Hematology.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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