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See publication for full list of authors.
W.Z. and T.Y.H. conceived the study, generated the hypotheses and designed the experiments. W.Z., F.Z., J.F., S.W., L.Z., D.B., L.Y., Y.X., B.N. and C.L. performed all the experiments and analysed the data. W.Z., C.J.L. and T.Y.H. wrote the manuscript. D.K., D.K.S., M.K. and A.J.R performed the P3 infection study. D.K. and D.K.S. conceived and designed the non-human primate study. B.S., S.L. and R.L. designed the portable device and the software for image processing. W.Z., C.J.L., S.M.L., J.S., J.N.E., Z.H. and T.Y.H. performed clinical experiments, and analysed and interpreted the clinical data. G.J.-S. and D.C.W. designed the parent PUSH trial study and obtained grant funding. I.N., L.M.C., D.C.W. and G.J.-S. developed the PUSH protocol and study. I.N., E.M.-O., D.C.W., L.M.C. and G.J.-S. assessed initial clinical data. J.S., I.N.N., L.M.C., S.M.L. and G.J.-S. analysed the primary trial data and/or subsequent TB diagnostic and clinical data. J.O., C.V., C.D.M., E.P.-T., E.A.G., D.T.N., N.N., H.P. and C.M.B. contributed to the clinical sample protocol for this study. All authors contributed to the writing of the manuscript and to its revision.
T.Y.H. and W.Z. have a provisional patent (‘Method of detecting TB in blood’) submitted through Tulane University. The rest of the authors declare no competing interests.
This work was primarily supported by research funding from the National Institutes of Health (U01CA252965, R01HD090927, R01AI122932, R01AI113725, R21Al126361-01, W8IXWH1910926 and R01HD103511 to T.Y.H.; R03AI140977 to J.F.; and R01AI162152 to S.M.L.). Analysis regarding the PUSH cohort was funded by NIAID K23AI120793 (S.M.L.) and NIAID R21AI143341 (S.M.L.). The original PUSH cohort was funded by NICHD R01-HD023412 (G.J.-S.). The primate studies were funded by P51OD011133 (D.K. and D.K.S.), P51OD011104 (D.K.), U42OD10442 (D.K.), R01AI134245 (D.K.), R01IAI111914 (D.K.) and R01AI134240 (D.K. and D.K.S.). We thank L. Lewy for proofreading the manuscript.
© The Author(s) 2022