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Z.L., E.J.G.R., O.H., H.G., Y.-H.C., N.K., M.L.H., K.D., M.M., D.L., P.B., J.C., Y.S.L., S.K.K., S.Z., L.L., R.C., F.R., R.P.D., R.D.D., N.M., V.B., G.A.S., L.D.N., E.S.M., L.S., S.-Y.Z., and J.-L.C. performed or supervised experiments, generated and analyzed data, and contributed to the manuscript by providing figures and tables. D.R., D.M., Y.S., B.M., A.C. and L.A. performed computational analysis of data. L.M., C.G., J.-L.S., S.B. and S.C. evaluated and recruited patients. Z.L, J.-L.C and S.-Y.Z., wrote the manuscript. J.-L.C. and S.-Y.Z. conceptualized and supervised the project. All the authors edited the manuscript.
We warmly thank our patients and their families. We thank the members of both branches of the Laboratory of Human Genetics of Infectious Diseases for helpful discussions; Tatiana Kochetkov for technical assistance; Yelena Nemirovskaya for administrative assistance. We thank the Bio-Imaging, Flow Cytometry Resource Center and Genomics Resource Center of The Rockefeller University for technical assistance. We thank Dusan Bogunovic for providing the human fibroblast cells with complete TBK1 deficiency.
Gregory A. Smith discloses a significant financial interest in Thyreos, Inc. All other authors declare no competing interests.
This work was conducted in the two branches of the Laboratory of Human Genetics of Infectious Diseases, and was funded in part by the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Clinical and Translational Science Award (CTSA) program, grant UL1TR001866, NIH grants R01AI088364, R01NS072381, R01AI020211 and R21AI151663, grants from the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID) and the French National Research Agency (ANR) under the “Investments for the future” program (ANR-10-IAHU-01), the ANR grants IEIHSEER (ANR-14-CE14-0008-01), SEAeHostFactors (ANR-18-CE15-0020-02), and CNSVIRGEN (ANR-19-CE15-0009-01), the French Foundation for Medical Research (FRM) (EQU201903007798), the Square Foundation, Grandir - Fonds de solidarité pour l’enfance, the SCOR Corporate Foundation for Science, the Rockefeller University, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cité University, and the St. Giles Foundation. LDN is supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Y.H.C. was supported by the A*STAR International Fellowship (AIF). P.B. was supported by the FRM (EA20170638020) and the MD-PhD program of the Imagine Institute (with the support of the Fondation Bettencourt Schueller). E.S.M. is supported by NIH grant R01AI020211.
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