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Author Notes:

Yubo Fan, Email: yubofan@buaa.edu.en

L.W. and K.J. contributed equally to the work. Designed the research: L.W., Y.F., and S.J.H. Materials PGD synthesized: L.W., K.J., H.R., and S.J.H. Mechanical test and data analysis: K.J., P.X., L.W., and Y.F. Biodegradation experiments and data analysis: K.J, L.W., Y.F. Biocompatible experiments and data analysis: K.J., L.W., H.Y., and Y.F. In-vivo implantation experiments and care for rats and rabbits: K.J., N.L., H.Y., and L.W. Histological observations and data analysis: K.J., H.Y., N.L., and L.W. Finite element model develop and data analysis: L.W., P.X., K.J., and Y.F. MRI images observations and T2 signal intensity analysis: N.L., K.J., and Y.F. Manuscript writing and editing: L.W., K.J., N.L., P.X., H.Y., H.R., S.J.H., and Y.F.

Y.F. and L.W. were supported by the National Natural Science Foundation of China (T2288101, 11822201, 11827803, 12172034, U20A20390). L.W. and K.J. acknowledged Beijing Municipal Natural Science Foundation (7212205) with financial support for this paper. Y.F. was supported by the 111 project (B13003). L.W. was supported by the Fundamental Research Funds for the Central Universities.

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Research Funding:

National Natural Science Foundation of China (T2288101, 11822201, 11827803, 12172034, U20A20390). L.W. and K.J. acknowledged Beijing Municipal Natural Science Foundation (7212205) with financial support for this paper. Y.F. was supported by the 111 project (B13003). L.W. was supported by the Fundamental Research Funds for the Central Universities.

Keywords:

  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • INTERVERTEBRAL DISC REGENERATION
  • SHAPE-MEMORY PROPERTIES
  • DEGENERATION
  • INJECTION
  • HYDROGELS
  • PUNCTURE

Innovative design of minimal invasive biodegradable poly(glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration

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Journal Title:

NATURE COMMUNICATIONS

Volume:

Volume 14, Number 1

Publisher:

, Pages 3865-3865

Type of Work:

Article | Final Publisher PDF

Abstract:

Minimally invasive biodegradable implants with regeneration have been a frontier trend in clinic. Degeneration of nucleus pulposus (NP) is irreversible in most of spine diseases, and traditional spinal fusion or discectomy usually injure adjacent segments. Here, an innovative minimally invasive biodegradable NP scaffold with function regeneration inspired by cucumber tendril is developed using shape memory polymer poly(glycerol-dodecanoate) (PGD), whose mechanical property is controlled to the similar with human NP by adjusting synthetic parameters. The chemokine stromal cell-derived factor-1α (SDF-1α) is immobilized to the scaffold recruiting autologous stem cells from peripheral tissue, which has better ability of maintaining disc height, recruiting autologous stem cells, and inducing regeneration of NP in vivo compared to PGD without chemokine group and hydrogel groups significantly. It provides an innovative way to design minimally invasive implants with biodegradation and functional recovery, especially for irreversible tissue injury, including NP, cartilage and so on.

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© 2024 Springer Nature Limited

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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