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Conceptualization, K.C.G., J.Y.L., H.C.J., H.T.S., and R.W., Methodology, K.C.G., J.Y.L., H.C.J., H.T.S., G.M.B., R.W.S., S.S., and R.W., Investigation, K.C.G., J.Y.L., H.C.J., A.S., V.M., S.S., M.J.S., K.K.P., A.F., A.A.P., J.S., A.H., and J.A.S.; Writing – Original Draft, J.Y.L., K.C.G., H.C.J., and H.T.S.; Writing – Review & Editing, J.Y.L., K.C.G., H.C.J., H.T.S., C.B.D., R.W., and S.S., Visualization, J.Y.L., K.C.G., and H.C.J.; Supervision, K.C.G. and H.T.S.
This research was supported by the Alex’s Lemonade Stand Foundation for Childhood Cancer Reach Award awarded to K.C.G. and H.T.S.; CURE Childhood Cancer through the Aflac Precision Medicine Program awarded to K.C.G.; Curing Kids Cancer awarded to H.T.S.; and the National Institutes of Health under an R01 grant (R01GM118803 to R.W.) and a T32 institutional training grant awarded to Emory University (5T32Hl069769-17 to H.C.J.). We thank the Children’s Healthcare of Atlanta and Emory University Pediatric/Winship Flow Cytometry Core for support with flow cytometry experiments and instrument use, the Winship Cancer Tissue Pathology Core at Emory University for support with IHC experiments, and the Department of Pathology at Children’s Healthcare of Atlanta for support with the development of the pediatric normal tissue microarray. The graphical abstract was created using BioRender.com.
The authors declare no competing interests.
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