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Vineet N. KewalRamani, vineet@mail.nih.gov
G.X., F.D.G., J.L., and V.N.K. oversaw the design of the entire study. G.X. conducted and analyzed most experiments. H.J.Y. collected and analyzed the microscopic imaging data. C.B. performed CA-NC binding experiment. G.X., H.J.Y, S.W.H., C.B., F.D.G., A.T.G., S.G.S., and V.N.K. helped with Figures. J.L. suggested important experiments to examine the biological function of factors in supporting HIV-1 infection. S.G.S. provided insight on CA interactions with multiple host factors. S.W.H., K.L., S.L.G., and M.H.G. provided valuable discussions/technical expertise/guidance. J.L., F.D.G., and V.N.K. supervised the experiments. G.X. and V.N.K. wrote the manuscript with input from all authors.
The authors thank Eric Freed, Henry Levin, and Owen Pornillos for scientific suggestions, and Eric Freed for MT4 cells. We thank Joseph Meyer from Scientific Publications, Graphics and Media, Frederick National Laboratory for assistance with figure graphics. Dr. Xue was an NIH Intramural AIDS Research Fellow and an NCI Sallie Rosen Kaplan Award recipient for women scientists. This research was supported by the Intramural Research Program of the NCI, Frederick National Lab, Center for Cancer Research. This work was also supported by NIH grants 5R01AI111809, 5DP1DA034990, and 1R01AI117839, to J.L. S.G.S. acknowledges support by NIH grants P50 GM103368 and R01 AI120860. F.D.-G., C.B. and A.B.-R. were supported by an R01 grant from the NIH AI087390, to F.D.-G. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.
G.X. is an employee of AstraZeneca and has stock ownership and/or stock options or interests in the company. The remaining authors declare no competing interests.
© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023