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Jian Hu, jian.hu@emory.edu
Linghua Wang, lwang22@mdanderson.org
Mingyao Li, mingyao@pennmedicine.upenn.edu
This study was conceived and led by M.L. J.H. designed the model and algorithm. J.H. implemented the TESLA software and led the data analysis with input from M.L., L.W., E.B.L., H.K., K.C., and D.Z. K.C. performed cell-type deconvolution analysis. E.B.L. examined the histology images. L.W. and H.K. provided marker genes for cancer and interpreted the results. L.W. provided guidance for the tumor TME analysis. J.H., M.L., and L.W. wrote the paper with feedback from all other coauthors.
This work was supported by the following grants: National Institutes of Health grants R01GM125301 (to M.L.), P01AG066597 (to E.B.L. and M.L.), U01CA264583 (to H.K., L.W., and M.L.), and Cancer Prevention and Research Institute of Texas (CPRIT) grant RP220101 (to H.K. and L.W.). L.W. was also supported in part by the Start-up Research fund and the Institutional Research Grant (IRG) awards provided by U.T. MD Anderson Cancer Center, the Andrew Sabin Family Fellowship provided by the Andrew Sabin Family Foundation, and the RP200385 award provided by CPRIT. We thank Dr. Kim Thrane for sharing the melanoma histology image data.
M.L. received research funding from Biogen Inc. unrelated to the current manuscript.