Fast correction of B-0 field inhomogeneity for pH-specific magnetization transfer and relaxation normalized amide proton transfer imaging of acute ischemic stroke without Z-spectrum

• Authors: Phillip Zhe Sun, Emory University
• Journal Title: MAGNETIC RESONANCE IN MEDICINE
• Volume: Volume 83, Number 5
• Publisher: WILEY | 2019-10-21, Pages 1688-1697
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1002/mrm.28040
• Subjects: Health Sciences, Radiology
• Keywords: Science & Technology; Life Sciences & Biomedicine; Radiology, Nuclear Medicine & Medical Imaging; SATURATION-TRANSFER CEST; IN-VIVO; QUANTITATIVE DESCRIPTION; TISSUE ACIDIFICATION; EXCHANGE-RATE; TRANSFER MRI; 3 T; RESONANCE; OPTIMIZATION; SENSITIVITY

Abstract

Purpose: The magnetization transfer and relaxation normalized amide proton transfer (MRAPT) analysis is promising to provide a highly pH-specific mapping of tissue acidosis, complementing commonly used CEST asymmetry analysis. We aimed to develop a fast B0 inhomogeneity correction algorithm for acute stroke magnetization transfer and relaxation normalized amide proton transfer imaging without Z-spectral interpolation. Methods: The proposed fast field inhomogeneity correction describes B0 artifacts with linear regression. We compared the new algorithm with the routine interpolation correction approach in CEST imaging of a dual-pH phantom. The fast B0 correction was further evaluated in amide proton transfer imaging of normal and acute stroke rats. Results: Our phantom data showed that the proposed fast B0 inhomogeneity correction significantly improved pH MRI contrast, recovering over 80% of the pH MRI contrast-to-noise-ratio difference between the raw magnetization transfer ratio asymmetry and that using the routine interpolation-based B0 correction approach. In normal rat brains, the proposed fast B0 correction improved pH-specific MRI uniformity across the intact tissue, with the ratio of magnetization transfer and relaxation normalized amide proton transfer ratio being 10% of that without B0 inhomogeneity correction. In acute stroke rats, fast B0 inhomogeneity–corrected pH MRI reveals substantially improved pH lesion conspicuity, particularly in regions with nonnegligible B0 inhomogeneity. The pH MRI contrast-to-noise ratio between the ipsilateral diffusion lesion and contralateral normal tissue improved significantly with fast B0 correction (from 1.88 ± 0.48 to 2.20 ± 0.44, P <.01). Conclusions: Our study established an expedient B0 inhomogeneity correction algorithm for fast pH imaging of acute ischemia.