Vibrio cholerae in rural and urban Bangladesh, findings from hospital-based surveillance, 2000–2021

• Authors: Rina Das, International Centre for Diarrhoeal Disease Research Bangladesh; Sabiha Nasrin, International Centre for Diarrhoeal Disease Research Bangladesh; Parag Palit, International Centre for Diarrhoeal Disease Research Bangladesh; Rukaeya A Sobi, International Centre for Diarrhoeal Disease Research Bangladesh; Al-Afroza Sultana, International Centre for Diarrhoeal Disease Research Bangladesh; Soroar H Khan, International Centre for Diarrhoeal Disease Research Bangladesh; Md Ahshanul Haque, International Centre for Diarrhoeal Disease Research Bangladesh; Sharika Nuzhat, International Centre for Diarrhoeal Disease Research Bangladesh; Tahmeed Ahmed, International Centre for Diarrhoeal Disease Research Bangladesh; ASG Faruque, International Centre for Diarrhoeal Disease Research Bangladesh; Mohammod Jobayer Chisti, International Centre for Diarrhoeal Disease Research Bangladesh
• Journal Title: Scientific Reports
• Volume: Volume 13, Number 1
• Publisher: Springer Nature Limited | 2023-12-01, Pages 6411-6411
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1038/s41598-023-33576-3
• Subjects: Biology, Biostatistics; Health Sciences, Epidemiology
• Keywords: Child; Humans; Female; Vibrio cholerae; Cholera; Bangladesh; Hospitals; Enterotoxigenic Escherichia coli; Water

Abstract

With more than 100,000 cases estimated each year, Bangladesh is one of the countries with the highest number of people at risk for cholera. Moreover, Bangladesh is formulating a countrywide cholera-control plan to satisfy the GTFCC (The Global Task Force on Cholera Control) Roadmap's goals. With a particular focus on cholera trends, variance in baseline and clinical characteristics of cholera cases, and trends in antibiotic susceptibility among clinical isolates of Vibrio cholerae, we used data from facility-based surveillance systems from icddr,b’s Dhaka, and Matlab Hospitals from years 2000 to 2021. Female patients comprised 3,553 (43%) in urban and 1,099 (51.6%) in rural sites. Of the cases and most patients 5,236 (63.7%) in urban and 1,208 (56.7%) in the rural site were aged 15 years and more. More than 50% of the families belonged to the poor and lower-middle-class; in 2009 (24.4%) were in urban and in 1,791 (84.2%) were in rural sites. In the urban site, 2,446 (30%) of households used untreated drinking water, and 702 (9%) of families disposed of waste in their courtyard. In the multiple logistic regression analysis, the risk of cholera has significantly increased due to waste disposal in the courtyard and the boiling of water has a protective effect against cholera. Rotavirus (9.7%) was the most prevalent co-pathogen among the under-5 children in both sites. In urban sites, the percentage of V. cholerae along with co-existing ETEC and Campylobacter is changing in the last 20 years; Campylobacter (8.36%) and Enterotoxigenic Escherichia coli (ETEC) (7.15%) were the second and third most prevalent co-pathogens. Shigella (1.64%) was the second most common co-pathogen in the rural site. Azithromycin susceptibility increased slowly from 265 (8%) in 2006–2010 to 1485 (47.8%) in 2016–2021, and erythromycin susceptibility dropped substantially over 20 years period from 2,155 (98.4%) to 21 (0.9%). Tetracycline susceptibility decreased in the urban site from 2051 (45.9%) to 186 (4.2%) and ciprofloxacin susceptibility decreased from 2,581 (31.6%) to 1,360 (16.6%) until 2015, then increased 1,009 (22.6%) and 1,490 (18.2%) in 2016–2021, respectively. Since 2016, doxycycline showed 902 (100%) susceptibility. Clinicians need access to up-to-date information on antimicrobial susceptibility for treating hospitalized patients. To achieve the WHO-backed objective of eliminating cholera by 2030, the health systems need to be put under a proper surveillance system that may help to improve water and sanitation practices and deploy oral cholera vaccines strategically.