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Author Notes:

Ao Zhang, zhangao@sysycc.org.cn

Xinjia Wang, xjwang4@stu.edu.cn

Prof XW and Dr AZ conceptualized and designed the study, and reviewed and revised the manuscript. Drs YM, NL designed the data collection instruments, carried out the initial analyses, and wrote the first draft of the manuscript. Drs JZ, YJ, YX, YOW, GZ, GJ, YAW, ZZ, GF, SH and CL coordinated and supervised data collection and critically reviewed the manuscript for important intellectual content. Drs YL, SC, XW, PZ, XL, YN, ML and SL collected data and reviewed and revised the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. The work reported in the paper has been performed by the authors, unless clearly specified in the text. All authors contributed to the article and approved the submitted version.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Subject:

Research Funding:

The Fellowship of China Postdoctoral Science Foundation (2021M692015 to YM); and National Natural Science Foundation of China Youth Science Fund Project (82102687 to YM; 82201922 to AZ).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • COVID-19 vaccines
  • Hashimoto thyroiditis
  • thyroid function
  • inflammation
  • mood change
  • AUTOIMMUNITY
  • OUTCOMES
  • HEALTH

Thyroid function and associated mood changes after COVID-19 vaccines in patients with Hashimoto thyroiditis

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Journal Title:

FRONTIERS IN IMMUNOLOGY

Volume:

Volume 14

Publisher:

, Pages 1129746-1129746

Type of Work:

Article | Final Publisher PDF

Abstract:

Context: Severe acute respiratory syndrome-coronavirus 2 (COVID-19) vaccines may incur changes in thyroid functions followed by mood changes, and patients with Hashimoto thyroiditis (HT) were suggested to bear a higher risk. Objectives: We primarily aim to find whether COVID-19 vaccination could induce potential subsequent thyroid function and mood changes. The secondary aim was to find inflammatory biomarkers associated with risk. Methods: The retrospective, multi-center study recruited patients with HT receiving COVID-19–inactivated vaccines. C-reactive proteins (CRPs), thyroid-stimulating hormones (TSHs), and mood changes were studied before and after vaccination during a follow-up of a 6-month period. Independent association was investigated between incidence of mood state, thyroid functions, and inflammatory markers. Propensity score–matched comparisons between the vaccine and control groups were carried out to investigate the difference. Results: Final analysis included 2,765 patients with HT in the vaccine group and 1,288 patients in the control group. In the matched analysis, TSH increase and mood change incidence were both significantly higher in the vaccine group (11.9% versus 6.1% for TSH increase and 12.7% versus 8.4% for mood change incidence). An increase in CRP was associated with mood change (p< 0.01 by the Kaplan–Meier method) and severity (r = 0.75) after vaccination. Baseline CRP, TSH, and antibodies of thyroid peroxidase (anti-TPO) were found to predict incidence of mood changes. Conclusion: COVID-19 vaccination seemed to induce increased levels and incidence of TSH surge followed by mood changes in patients with HT. Higher levels of pre-vaccine serum TSH, CRP, and anti-TPO values were associated with higher incidence in the early post-vaccine phase.

Copyright information:

© 2023 Ma, Zeng, Jiang, Xu, Wang, Zhong, Liu, Wang, Zhang, Li, Chen, Wei, Zhu, Jian, Lyu, Niu, Li, Liang, Fu, He, Liu, Zhang and Wang

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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