Editorial: The role of calcium channels in human health and disease-Volume II

• Authors: Peng Zhang, Shenzhen Inst Otorhinolaryngol; Chang-Bo Zheng, Kunming Medical University; Zhen Chen, Emory University; Xiao-Yu Liu, Southern University of Science & Technology
• Journal Title: FRONTIERS IN MOLECULAR BIOSCIENCES
• Volume: Volume 10
• Publisher: FRONTIERS MEDIA SA | 2023-03-21, Pages 1180456-1180456
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.3389/fmolb.2023.1180456
• Subjects: Health Sciences, Pharmacology; Health Sciences, Oncology
• Keywords: Science & Technology; Life Sciences & Biomedicine; Biochemistry & Molecular Biology; calcium channels; calcium signal; human health; human disease; therapeutic target

Abstract

Calcium is among the most important second messengers in the cells and participates in multiple physiological and pathological progress (Baird GS, 2011). The extracellular calcium concentration (about 1–2 mmol/L) is much higher than the cytoplasmic concentration (about 100–200 nmol/L) in resting condition, and more than 90% of cytoplasmic calcium is stored in intracellular calcium pools (endoplasmic reticulum and mitochondria) (Matikainen et al., 2021). Calcium channels mediate the calcium influx or calcium release from intracellular pools in response to various stimuli. Abnormal calcium homeostasis is associated with various pathologic disorders, including cardiovascular diseases, cancer, immune diseases, and neurological disorders (Berridge MJ, 2012). Therefore, understanding how calcium channels regulate calcium homeostasis is important for identifying novel therapeutic targets. This Research Topic entitled “The Role of Calcium Channels in Human Health and Disease—Volume II” features the critical role of calcium channels in regulating human health and disease. The six studies included in this special Research Topic focus on the novel roles of calcium channels in pathophysiological processes.