Evaluation of wound healing effects of micronized acellular dermal matrix in combination with negative pressure wound therapy: In vivo study

• Authors: Jeongmok Cho, University of Ulsan College of Medicine; Hyun Hwang, Emory University School of Medicine; Shin Young Song, University of Ulsan College of Medicine; Hyunsuk P Suh, University of Ulsan College of Medicine; Joon Pio Hong, University of Ulsan College of Medicine
• Journal Title: International Wound Journal
• Volume: Volume 20, Number 4
• Publisher: Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. | 2023-04-01, Pages 1053-1060
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1111/iwj.13958
• Subjects: Health Sciences, Medicine and Surgery
• Keywords: collagen; gelatin; micronized acellular dermal matrix; porcine model; wound healing; Swine; Animals; Acellular Dermis; Negative-Pressure Wound Therapy; Gelatin; Wound Healing; Collagen; Skin Transplantation

Abstract

Acellular dermal matrix (ADM) grafts can provide coverage for full-thickness skin defects and substitute for dermal defects. We tested the effectiveness of micronized ADM (mADM) as a dressing material, combined with negative pressure wound therapy (NPWT), for managing superficial wounds. We compared the wound healing effect of mADM in combination with NPWT with those of gelatin and mADM applied with a foam dressing. These therapeutic materials were applied to 36 cm2 excisional wounds in a porcine full-thickness skin defect model. Wound healing kinetics and new tissue formation were assessed 10 days after the initial treatment by measuring the wound area. Collagen deposition and neovascularization were histologically evaluated. Compared with the other two groups, mADM plus NPWT combination group had a significantly larger wound area at the baseline (P =.0040), but the smallest on the 7th day (P =.0093). In addition, collagen formation and neovascularization were more histologically promoted than in the other two groups. mADM showed better results than the gelatin group but less collagen and revascularization than the combination group, and there was no significant difference in wound area. Our results show that the combination of mADM and NPWT has a synergistic wound healing effect.