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Author Notes:

Mehmet Asim Bilen, mehmet.a.bilen@emory.edu

TZ and SM drafted the editorial. MB and KB edited the manuscript. All authors contributed to this work and gave approval to the final version.

MB has acted as a paid consultant for and/or as a member of the advisory boards of Exelixis, Bayer, BMS, Eisai, Pfizer, AstraZeneca, Janssen, Calithera Biosciences, Genomic Health, Nektar, EMD Serono, SeaGen, and Sanofi, and his institution has received grants from Merck, Xencor, Bayer, Bristol-Myers Squibb, Genentech/Roche, SeaGen, Incyte, Nektar, AstraZeneca, Tricon Pharmaceuticals, Genome & Company, AAA, Peloton Therapeutics, and Pfizer for work performed outside of the current study. KB has acted as a paid consultant for and/or as a member of the advisory boards of LCFA-BMS-IASLC for Young Investigator Award, Alpine Biosciences, Aravive, Astrazeneca, Aveo, BMS, Exelexis, Merck, Sanofi, and Seagen. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Subject:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • renal cell carcinoma
  • biomarker
  • immunotherapy
  • next-generation sequencing cytoreduction

Editorial: Case reports in renal cell carcinoma

Tools:

Journal Title:

FRONTIERS IN ONCOLOGY

Volume:

Volume 13

Publisher:

, Pages 1165013-1165013

Type of Work:

Article | Final Publisher PDF

Abstract:

Renal cell carcinoma (RCC) is one of the most common malignancies worldwide with nearly 81,000 new cases and 15,000 deaths annually (1). Clear cell RCC (ccRCC) is the most common histologic subtype. Immune checkpoint inhibitors (ICI) have been approved as a frontline treatment in recent years, with nivolumab/cabozantinib, pembrolizumab/levantinib, and pembrolizumab/axitinib approved for all risk groups, while nivolumab/ipilimumab is reserved for intermediate-to-poor risk disease (2–7). While the presentation of case reports and series may not represent practice-changing data, we believe it can spark new thoughts regarding biology, mechanisms, therapeutic options, and responses. Despite significant advances in immunotherapy and the discovery of novel biomarkers, the management of RCC is complex, owing to its heterogeneity, with multiple histological and genomic subtypes. This brief review describes 12 unique cases presented by 87 authors exploring the role of next-generation sequencing in treatment selection, rare disease and treatment complications, and the management of oligometastatic disease.

Copyright information:

© 2023 Zhuang, Mustafa, Beckermann and Bilen

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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