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Stephen F. Traynelis, strayne@emory.edu
Synthesis of the 93 series compounds was completed by Y.A.T., N.S.A., and L.D.H. Oocyte recordings were performed by K.A.N. and L.D.H. S.J.M. performed the triheteromeric recordings. Crystal structure data were provided by H.F. and M.C.R. Spinal nerve ligation and plasma and brain concentration data were collected and analyzed by R.D., S.J.M., and L.J.W. L.D.H performed all tail immersion and locomotor experiments. L.D.H., M.C.R., S.J.M., H.F., L.J.W., R.D., S.F.T., and D.C.L. were involved in experimental design. Data were analyzed by L.D.H., M.C.R., S.J.M., and H.F. All authors were involved in writing the manuscript.
The authors thank Sukhan Kim and James Allen for their excellent technical assistance. They also thank Robert Gereau, PhD, and Shannon Gourley, PhD, for their guidance and feedback on the experimental design and analysis of the work reported here. Receptor binding profiles and Ki determinations were generously provided by the National Institute of Mental Health’s Psychoactive Drug Screening Program, Contract # HHSN-271-2018-00023-C (NIMH PDSP). The NIMH PDSP is Directed by Bryan L. Roth, MD, PhD, at the University of North Carolina at Chapel Hill and Project Officer Jamie Driscoll at NIMH, Bethesda, MD, United States. We thank the staff at the 17-ID beamlines at the Brookhaven National Laboratory NSLSII, in particular Jean Jakoncic, Alexei Soares, and Vivian Stojanoff, for help with data collection. An atomic coordinate and structure factor for the GluN1b-GluN2B ATDs with EU93-108 is deposited to the Protein Data Bank under the accession code, 8G18.
The authors declare the following competing financial interest(s): S.F.T. is a member of the SAB for Sage Therapeutics, Eumentis Therapeutics, the GRIN2B Foundation, CureGRIN Foundation, a consultant for GRIN Therapeutics, a co-founder of NeurOp, Inc. and AgriThera, and a member of the Board of Directors for NeurOp, Inc. D.C.L. is a member of the Board of Directors for NeurOp, Inc. and co-founder of AgriThera. R.D. is a member of the Board of Directors for NeurOp, Inc. and chair of the Board of Pyrefin, Inc., and a co-founder of NeurOp, Inc. and Pyrefin, Inc.
© 2023 The Authors. Published by American Chemical Society