About this item:

27 Views | 8 Downloads

Author Notes:

Dr. Loretta Z. Reyes, MD, Assistant Professor, Division of Pediatric Nephrology, Emory University School of Medicine, Atlanta, Georgia, USA, Children’s Healthcare of Atlanta, Atlanta, Georgia, USA. Email: loretta.reyes@emory.edu

Claudia R. Morris, MD, is the inventor or co-inventor of several UCSF-Benioff Children’s Hospital Oakland patents/patent-pending applications that include nutritional supplements, and biomarkers of cardiovascular disease related to arginine bioavailability, is an inventor/co-inventor several Emory University School of Medicine patent applications for nutritional supplements, is a consultant for Pfizer, CSL Behring, F. Hoffmann-La Roche LTd, and has received research support from the United States Food and Drug Administration, Health Resources & Services Administration (HRSA, agency of the US Department of Health and Human Services) and the National Institutes of Health.

The authors have no conflicts of interest to declare.


Research Funding:

Food and Drug Administration-R01FD004814-01A2 and in part, the National Center for Complementary and Integrative Health K24AT009893-01


  • Science & Technology
  • Life Sciences & Biomedicine
  • Hematology

Safety of intravenous arginine therapy in children with sickle cell disease hospitalized for vaso-occlusive pain: A randomized placebo-controlled trial in progress


Journal Title:



Volume 97, Number 1


, Pages E21-E24

Type of Work:

Article | Post-print: After Peer Review


Sickle cell disease (SCD) is the most common hemoglobinopathy in the United States and vaso-occlusive pain episodes (VOE) are the leading cause of hospitalizations and emergency department (ED) visits1. There are limited therapies for acute management of VOE that directly target the underlying etiology for sickle-related pain therefore treatment is largely symptomatic. Moderate-to-severe pain is typically treated with parenteral hydration, opioids, and hospitalization to achieve adequate pain control.
Export to EndNote