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Author Notes:

Albert M. Anderson, Emory University School of Medicine, 341 Ponce de Leon Avenue, Atlanta, GA 30308, Phone: 404-616-3147, Fax: 404-616-9702. Email: aande2@emory.edu

The authors also gratefully acknowledge funding from the following sources: K23 MH095679, R21 MH118092, R01 AG062387 (Principal Investigator: A. Anderson) and P30AI050409 (Emory Center for AIDS Research). The study sponsors had no involvement in the design or performance of the project or the analysis of the results.

Disclosures: None

Subject:

Research Funding:

Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS), now the MACS/WIHS Combined Cohort Study (MWCCS).

The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). MWCCS (Principal Investigators): Atlanta CRS (Ighovwerha Ofotokun, Anandi Sheth, and Gina Wingood), U01-HL146241; Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; Brooklyn CRS (Deborah Gustafson and Tracey Wilson), U01-HL146202; Data Analysis and Coordination Center (Gypsyamber D’Souza, Stephen Gange and Elizabeth Golub), U01-HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146245; Chicago-Northwestern CRS (Steven Wolinsky), U01-HL146240; Northern California CRS (Bradley Aouizerat, Jennifer Price, and Phyllis Tien), U01-HL146242; Los Angeles CRS (Roger Detels and Matthew Mimiaga), U01-HL146333; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Miami CRS (Maria Alcaide, Margaret Fischl, and Deborah Jones), U01-HL146203; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo), U01-HL146208; UAB-MS CRS (Mirjam-Colette Kempf, Jodie Dionne-Odom, and Deborah Konkle-Parker), U01-HL146192; UNC CRS (Adaora Adimora), U01-HL146194. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional co-funding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR000004 (UCSF CTSA), UL1-TR003098 (JHU ICTR), UL1-TR001881 (UCLA CTSI), P30-AI-050409 (Atlanta CFAR), P30-AI-073961 (Miami CFAR), P30-AI-050410 (UNC CFAR), P30-AI-027767 (UAB CFAR), and P30-MH-116867 (Miami CHARM).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Infectious Diseases
  • Virology
  • NEUROCOGNITIVE IMPAIRMENT
  • INFECTED PATIENTS
  • PERFORMANCE

GlycA is associated with neuropsychological impairment in men with HIV

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Journal Title:

AIDS

Volume:

Volume 36, Number 1

Publisher:

, Pages 156-159

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Neuropsychological impairment (NPI) remains prevalent among people with HIV (PWH) despite combination antiretroviral therapy (ART).[1, 2] NPI is associated with reduced quality of life,[3] worse everyday functioning,[4] and increased mortality risk.[5, 6] Chronic inflammation may underpin NPI.[7–9] The composite blood biomarker GlycA results from the enzymatic glycosylation of circulating proteins.[10] The proteins with the highest representation within the GlycA signal include α1-acid glycoprotein, haptoglobin, α1-antitrypsin, α1-antichymotrypsin, and transferrin. Thus, GlycA appears to be an overall measure of inflammation and concentrations are relatively stable over time.[10] Higher GlycA concentration was associated with coronary artery calcification in the Multicenter AIDS Cohort Study (MACS) cardiovascular (CVD) substudy.[11–13] We investigated whether GlycA might be associated with NPI.

Copyright information:

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/).
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