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Author Notes:

Email: ppanuwe@emory.edu

Conceptualization, K.J.B., A.L.D., P.B.R., D.B.B. and P.P.; methodology, K.J.B., C.L.J., J.C., C.-C.T., E.I.G., P.D., A.L.D., P.B.R., D.B.B. and P.P.; validation, K.J.B., C.L.J., J.C., P.P.; formal analysis, K.J.B., D.B.B. and P.P.; investigation, A.L.D., P.B.R., D.B.B., P.P.; resources, D.B.B. and P.B.R.; data curation, K.J.B., D.B.B., P.P.; writing—original draft preparation, K.J.B.; writing—review and editing, K.J.B., C.L.J., J.C., P.D., E.I.G., A.L.D., P.B.R., C.-C.T., D.B.B., E.J.C. and P.P.; visualization, K.J.B., P.B.R., D.B.B., P.P.; supervision, A.L.D., P.B.R., D.B.B., P.P.; project administration, A.L.D., E.J.C., P.B.R., D.B.B.; funding acquisition, A.L.D., P.B.R., E.J.C. and D.B.B. All authors have read and agreed to the published version of the manuscript.

We would like to thank all the study participants, and the clinical health care providers and staff at the prenatal recruiting sites for helping with data and sample collection, and logistics and sample chemical analyses in the laboratory, especially Nathan Mutic, Nikolay Patrushev, Kristi Maxwell Logue, Castalia Thorne, Shirleta Reid, and Cassandra Hall.

The authors declare no conflict of interest.

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Research Funding:

This work was supported by the National Institute of Health (NIH) research grants (R01NR014800, R01MD009064, R24ES029490, R01MD009746, R21ES032117), NIH Center Grants (P50ES02607, P30ES019776, UH3OD023318, U2CES026560), and Environmental Protection Agency (USEPA) center grant (83615301).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Environmental Sciences
  • Toxicology
  • Environmental Sciences & Ecology
  • dust
  • persistent organic pollutants
  • Atlanta
  • African American
  • pregnant
  • PERSISTENT ORGANIC POLLUTANTS
  • POLYBROMINATED DIPHENYL ETHERS
  • NATIONAL-HEALTH
  • HUMAN EXPOSURE
  • POLYCHLORINATED BIPHENYL
  • URINARY CONCENTRATIONS
  • SERUM CONCENTRATIONS
  • FLAME RETARDANTS
  • US POPULATION
  • INDOOR DUST

Legacy Chemical Pollutants in House Dust of Homes of Pregnant African Americans in Atlanta

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Journal Title:

TOXICS

Volume:

Volume 10, Number 12

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Type of Work:

Article | Final Publisher PDF

Abstract:

We developed and applied a method for measuring selected persistent organic pollutants (POPs) (i.e., polybrominated diphenyl ethers (PBDEs), organochlorine pesticides, and polychlorinated biphenyls (PCBs)) in dust collected from pregnant African Americans (AAs) in Atlanta using isotope dilution gas chromatography-tandem mass spectrometry. Limits of quantification were ranged from 0.10 to 2.50 ng/g dust. NIST standard reference material measurements demonstrated the robustness of our method. Our accuracies ranged from 82 to 108%, relative standard deviations ranged from 2 to 16%, and extraction recoveries ranged from 76 to 102%. We measured POPs in dust collected from 34 homes of pregnant AAs participating in the Atlanta AA birth cohort study who were enrolled from 2016 to 2019. Concentrations of POPs were detected in all samples with the frequencies of detection ranging from 8 to 100%. Concentrations of PBDE congeners 99 and 47, p,p’-DDT, and PCB153 were detected at some of the highest concentrations with geometric means of 1270, 730, 63.4 and 240 ng/g, respectively. The ratio of DDT/DDE was quite large (~2.7) indicating that p,p’-DDT remains intact in homes for long periods of time. These data demonstrate that care should be taken to remediate POPs in indoor dust, especially in vulnerable, disparate segments of the population.

Copyright information:

© 2022 by the authors.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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