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Author Notes:

Dr. Jean Addington, Mathison Centre for Mental Health Research & Education, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 Canada. Email: jmadding@ucalgary.ca

The study was designed by Addington, Cannon, Cornblatt, Cadenhead, Woods, McGlashan, Perkins, Tsuang, Bearden, Walker, Mathalon, & Seidman. Liu undertook data analysis. Addington wrote the first draft of the manuscript. All authors contributed to and have approved the final manuscript.

This study was supported by the National Institute of Mental Health (grant U01MH081984 to Dr Addington; grant U01MH081928 to Dr Stone; grant U01MH081944 to Dr Cadenhead; grant U01MH081902 to Drs Cannon and Bearden; grant U01MH082004 to Dr Perkins; grant U01MH081988 to Dr Walker; grant U01MH082022 to Dr Woods; grant U01MH076989 to Dr Mathalon; grant UO1MH081857 to Dr Cornblatt).

Authors declare they have no conflict of interest with respect to this study.



  • Clinical high risk
  • Methodology
  • Psychosis
  • Schizophrenia
  • Adolescent
  • Humans
  • Longitudinal Studies
  • North America
  • Prodromal Symptoms
  • Prospective Studies
  • Psychotic Disorders

North American Prodrome Longitudinal Study (NAPLS 3): Methods and baseline description

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Journal Title:

Schizophrenia Research


Volume 243


, Pages 262-267

Type of Work:

Article | Post-print: After Peer Review


The North American Prodrome Longitudinal Study (NAPLS) is a consortium of nine programs focusing on youth at clinical high risk (CHR) for psychosis. Funded by the National Institute of Mental Health (NIMH), the sites are located at Emory University, Harvard University, University of Calgary, University of California at Los Angeles, at San Diego, and at San Francisco, University of North Carolina Chapel Hill, Yale University, and Zucker Hillside Hospital. There have been two previous endeavors completed by this consortium, known as NAPLS-1 and NAPLS-2. This paper first offers an overview of the methodology of the third phase of the NAPLS consortium, the second five-year prospective study NAPLS-3, which aims to determine mechanisms of the development of psychosis. In addition, we report on the ascertainment and demographics of the 710 CHR participants in NAPLS-3.

Copyright information:

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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