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Author Notes:

Edward P. Chen, MD, Professor of Surgery, Division of Cardiothoracic Surgery, 5665 Peachtree Dunwoody Rd, Suite 200, Atlanta, GA 30342. Email: edward.p.chen@emory.edu



  • Science & Technology
  • Life Sciences & Biomedicine
  • Cardiac & Cardiovascular Systems
  • Respiratory System
  • Surgery
  • Cardiovascular System & Cardiology

Fifteen Years of Aortic Valve-sparing Root Replacement and Impact of Eccentric Jets on Late Outcomes


Journal Title:



Volume 112, Number 6


, Pages 1901-1907

Type of Work:

Article | Post-print: After Peer Review


Background: Valve-sparing root replacement is more challenging with eccentric aortic insufficiency due to cusp and root asymmetry, which may impact valve durability and survival. This study analyzed the effect of jet eccentricity on long-term outcomes in tricuspid aortic valves (TAVs) and bicuspid aortic valves (BAVs). Methods: From 2005 to 2019, 111 patients (65 TAVs, 46 BAVs) with >2+ aortic insufficiency underwent valve-sparing root replacement at an academic center. Pre- and postoperative echocardiograms were analyzed. Of these, 32 patients presented with concentric jets (29 TAVs, 3 BAVs) and 71 with eccentric jets (28 TAVs, 43 BAVs). Median follow-up was 49 months (interquartile range, 12-93). Kaplan-Meier analysis and cumulative risk were used to compare long-term survival and valve-related reintervention. Results: Mean patient age was 44 ± 12 years. Compared with TAV, more BAV patients presented with eccentric jets (93.5% vs 43.1%, P <.001). All BAV patients received cusp repair compared with 52.3% of TAV patients (P <.001). At 3, 5, and 10 years the cumulative risk of aortic valve replacement for TAV (4.7%, 6.4%, and 6.4%) versus BAV (5.8%, 7.8%, and 7.8%) patients (P =.87) and concentric (0%, 0%, and 0%) versus eccentric (6.4%, 9.4%, and 9.4%) jets (P =.98) was similar. Overall survival at 10 years was 71% for TAV and 97% for BAV (P =.19) and 86% for concentric and 79% for eccentric jets (P =.17). Conclusions: In patients presenting for valve-sparing root replacement with >2+ aortic insufficiency the risk of valve-related reintervention long term was low after cusp repair in TAVs and BAVs. Current results suggest preoperative jet eccentricity does not impact long-term survival and valve durability.

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This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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