Liver, visceral and subcutaneous fat in men and women of South Asian and white European descent: a systematic review and meta-analysis of new and published data

• Authors: Stamatina Iliodromiti, Queen Mary University London; James McLaren, University of Glasgow; Nazim Ghouri, University of Glasgow; Melissa R Miller, Pfizer; Olof Dahlqvist Leinhard, AMRA Med AB; Jennifer Linge, AMRA Med AB; Stuart Ballantyne, Greater Glasgow and Clyde NHS; Jonathan Platt, Greater Glasgow and Clyde NHS; John Foster, Beatson West Scotland Canc Ctr; Scott Hanvey, Derriford Hospital; Unjali Gujral, Emory University; Alka Kanaya, University of California San Francisco; Naveed Sattar, University of Glasgow; Mary Ann Lumsden, University of Glasgow; Jason MR Gill, University of Glasgow
• Journal Title: DIABETOLOGIA
• Volume: Volume 66, Number 1
• Publisher: SPRINGER | 2022-10-13, Pages 44-56
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1007/s00125-022-05803-5
• Subjects: Health Sciences, Radiology; Physics, Radiation
• Keywords: Science & Technology; Life Sciences & Biomedicine; Endocrinology & Metabolism; Abdominal; Computed tomography; Fat; Liver; Magnetic Resonance Imaging; Meta-analysis; South Asian; Systematic review; Visceral; CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; CENTRAL OBESITY; RISK; PREVALENCE; MORTALITY; ENGLAND; COUNTRY; WALES; BIRTH

Abstract

Aims/hypothesis: South Asians have a two- to fivefold higher risk of developing type 2 diabetes than those of white European descent. Greater central adiposity and storage of fat in deeper or ectopic depots are potential contributing mechanisms. We collated existing and new data on the amount of subcutaneous (SAT), visceral (VAT) and liver fat in adults of South Asian and white European descent to provide a robust assessment of potential ethnic differences in these factors. Methods: We performed a systematic review of the Embase and PubMed databases from inception to August 2021. Unpublished imaging data were also included. The weighted standardised mean difference (SMD) for each adiposity measure was estimated using random-effects models. The quality of the studies was assessed using the ROBINS-E tool for risk of bias and overall certainty of the evidence was assessed using the GRADE approach. The study was pre-registered with the OSF Registries (https://osf.io/w5bf9). Results: We summarised imaging data on SAT, VAT and liver fat from eight published and three previously unpublished datasets, including a total of 1156 South Asian and 2891 white European men, and 697 South Asian and 2271 white European women. Despite South Asian men having a mean BMI approximately 0.5–0.7 kg/m2 lower than white European men (depending on the comparison), nine studies showed 0.34 SMD (95% CI 0.12, 0.55; I2=83%) more SAT and seven studies showed 0.56 SMD (95% CI 0.14, 0.98; I2=93%) more liver fat, but nine studies had similar VAT (−0.03 SMD; 95% CI −0.24, 0.19; I2=85%) compared with their white European counterparts. South Asian women had an approximately 0.9 kg/m2 lower BMI but 0.31 SMD (95% CI 0.14, 0.48; I2=53%) more liver fat than their white European counterparts in five studies. Subcutaneous fat levels (0.03 SMD; 95% CI −0.17, 0.23; I2=72%) and VAT levels (0.04 SMD; 95% CI −0.16, 0.24; I2=71%) did not differ significantly between ethnic groups in eight studies of women. Conclusions/interpretation: South Asian men and women appear to store more ectopic fat in the liver compared with their white European counterparts with similar BMI levels. Given the emerging understanding of the importance of liver fat in diabetes pathogenesis, these findings help explain the greater diabetes risks in South Asians. Funding: There was no primary direct funding for undertaking the systematic review and meta-analysis. Graphical abstract: [Figure not available: see fulltext.]