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Andrei G. Fedorov, agf@gatech.edu
A.G.F. and P.A.K. conceived of the idea for the microfluidic platform and formulated research goals. A.L.C. designed, built, validated, and applied the platform with assistance and supervision from M.A.C., P.A.K, and A.G.F. Cell culture, harvesting, and biological insight were provided by D.G. and A.C.B-W. A.L.C. interpreted results and wrote the initial draft with significant input from M.A.C., P.A.K, and A.G.F. The final draft was completed with assistance from all authors.
The work described herein is supported by NSF Center for Cell Manufacturing Technologies (CMaT) Award 1648035, NSF Graduate Research Fellowship Grant No. DGE-1148903, the Marcus Center for Therapeutic Cell Characterization and Manufacturing Collaboration Grant in Cell Manufacturing, the Georgia Tech Foundation, and the Georgia Research Alliance. Partial support was also provided by Grant Number R01 GM138802 from the National Institute of General Medical Science (NIGMS), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NSF, NIGMS or NIH. Device fabrication was performed at the Georgia Tech Institute for Electronics and Nanotechnology, a member of the National Nanotechnology Coordinated Infrastructure (NNCI), which is supported by National Science Foundation Grant ECCS-2025462. The authors would like to acknowledge the Roy lab, specifically Nate Dwarshuis and Miguel Armenta Ochoa, and the Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M) staff for technical assistance with cell culture experiments.
Mason Chilmonczyk and Andrei Fedorov are inventors of the technology and are pursuing its commercialization. The terms of this arrangement have been reviewed and approved by Georgia Tech in accordance with its conflict of interest policies.