Effects of prenatal alcohol exposure on cognitive and behavioral development: Findings from a hierarchical meta-analysis of data from six prospective longitudinal US cohorts

• Authors: Joseph L Jacobson, Wayne State University; Tugba Akkaya-Hocagil, University of Waterloo; Louise M Ryan, University of Technology Sydney; Neil C Dodge, Wayne State University; Gale A Richardson, University of Pittsburgh; Heather C Olson, University of Washington; Claire Coles, Emory University; Nancy L Day, University of Pittsburgh; Richard J Cook, University of Waterloo; Sandra W Jacobson, Wayne State University
• Journal Title: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
• Volume: Volume 45, Number 10
• Publisher: WILEY | 2021-08-26, Pages 2040-2058
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1111/acer.14686
• Subjects: Statistics; Mathematics; Health Sciences, Mental Health
• Keywords: Science & Technology; Life Sciences & Biomedicine; Substance Abuse; behavior problems; causal analysis; cognitive development; fetal alcohol spectrum disorders; IQ; meta-analysis; multiple outcomes; prenatal alcohol exposure; CITY CHILD CHARACTERISTICS; MATERNAL RISK TRAITS; SPECTRUM DISORDERS; ATTENTION-DEFICIT; ACADEMIC-ACHIEVEMENT; MEMORY IMPAIRMENT; WORKING-MEMORY; SCHOOL-AGE; DRUG-USE; ADOLESCENTS

Abstract

Background: Cognitive and behavioral sequelae of prenatal alcohol exposure (PAE) continue to be prevalent in the United States and worldwide. Because these sequelae are also common in other neurodevelopmental disorders, researchers have attempted to identify a distinct neurobehavioral profile to facilitate the differential diagnosis of fetal alcohol spectrum disorders (FASD). We used an innovative, individual participant meta-analytic technique to combine data from six large U.S. longitudinal cohorts to provide a more comprehensive and reliable characterization of the neurobehavioral deficits seen in FASD than can be obtained from smaller samples. Methods: Meta-analyses were performed on data from 2236 participants to examine effects of PAE (measured as oz absolute alcohol/day (AA/day)) on IQ, four domains of cognition function (learning and memory, executive function, reading achievement, and math achievement), sustained attention, and behavior problems, after adjusting for potential confounders using propensity scores. Results: The effect sizes for IQ and the four domains of cognitive function were strikingly similar to one another and did not differ at school age, adolescence, or young adulthood. Effect sizes were smaller in the more middle-class Seattle cohort and larger in the three cohorts that obtained more detailed and comprehensive assessments of AA/day. PAE effect sizes were somewhat weaker for parent- and teacher-reported behavior problems and not significant for sustained attention. In a meta-analysis of five aspects of executive function, the strongest effect was on set-shifting. Conclusions: The similarity in the effect sizes for the four domains of cognitive function suggests that PAE affects an underlying component or components of cognition involving learning and memory and executive function that are reflected in IQ and academic achievement scores. The weaker effects in the more middle-class cohort may reflect a more cognitively stimulating environment, a different maternal drinking pattern (lower alcohol dose/occasion), and/or better maternal prenatal nutrition. These findings identify two domains of cognition—learning/memory and set-shifting—that are particularly affected by PAE, and one, sustained attention, which is apparently spared.