Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature

• Authors: Alexandra D Forrest, Emory University; Danielle M Vuncannon, Emory University; Jane Ellis, Emory University; Zvi Grunwald, Thomas Jefferson University Hospital; Frederick S Kaplan, University of Pennsylvania
• Journal Title: Case Reports in Obstetrics and Gynecology
• Volume: Volume 2022
• Publisher: Hindawi | 2022-01-01, Pages 9857766-9857766
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1155/2022/9857766
• Subjects: Health Sciences, Obstetrics and Gynecology; Health Sciences, Medicine and Surgery
• Keywords: Fibrodysplasia

Abstract

Objective. To evaluate maternal and fetal outcomes in pregnant patients with fibrodysplasia ossificans progressiva (FOP; OMIM#135100), an ultrarare genetic disorder characterized by progressive heterotopic ossification of soft tissues and cumulative disability. Methods. This is a retrospective case series of three patients with FOP who were admitted to Grady Memorial Hospital in Atlanta, Georgia, from to February 2011 to July 2021. Results. Three women delivered preterm infants at our institution. These cases posed unique anesthetic and obstetric technical challenges, particularly when securing the airway and performing cesarean delivery. Importantly, each patient received perioperative glucocorticoids for prevention of further heterotopic ossification. Conclusion. FOP is a unique clinical diagnosis encountered by obstetricians and requires multidisciplinary management for optimal outcomes.