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Author Notes:

Jesse J. Waggoner, MD, 1760 Haygood Drive NE, Room E-169, Bay E-1, Atlanta, GA 30322; jjwaggo@emory.edu

Potential conflicts of interest. All authors: No reported conflicts of interest.

The authors acknowledge the contribution of all research staff and team members involved in the Paraguay, ROAPS, and ELIAD studies, without whom this research would not have been possible.


Research Funding:

This work was supported by funding from the Consejo Nacional de Ciencia y Tecnología (CONACYT) with support from el Fondo para la Excelencia de la Educacción y la Investigación (FEEI), Paraguay, PINV20-239 (to M. M.); the National Institutes of Health (grant numbers U54 EB027690 02S1, U54 EB027690 03S1, U54EB027690 03S2, and UL1TR002378); and the Doris Duke Charitable Foundation (Clinical Scientist Development Award 2019089 to J. J. W.). The ROAPS study is supported by a contract from Pfizer, Inc.


  • severe acute respiratory syndrome coronavirus 2
  • subgenomic RNA
  • variants of concern

Subgenomic RNA Abundance Relative to Total Viral RNA Among Severe Acute Respiratory Syndrome Coronavirus 2 Variants

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Journal Title:

Open Forum Infectious Diseases


Volume 9, Number 11


, Pages ofac619-ofac619

Type of Work:

Article | Final Publisher PDF


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subgenomic RNA (sgRNA) may indicate actively replicating virus, but sgRNA abundance has not been systematically compared between SARS-CoV-2 variants. sgRNA was quantified in 169 clinical samples by real-time reverse-transcription polymerase chain reaction, demonstrating similar relative abundance among known variants. Thus, sgRNA detection can identify individuals with active viral replication regardless of variant.

Copyright information:

© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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