Caregiver willingness to give TPT to children living with drug- resistant TB patients

• Authors: V Rouzier, GHESKIO Centers; M Murrill, Johns Hopkins Medical Institutions; S Kim, Frontier Science Foundation; L Naini, Social and Scientific Systems, Inc.; J Shenje, South African Tuberculosis Vaccine Initiative (SATVI); E Mitchell, University of Cape Town; M Raesi, Gaborone Clinical Research Site; M Lourens, TASK Applied Science Clinical Research Site; A Mendoza, Barranco Clinical Research Site; F Conradie, Sizwe Tropical Disease Hospital; N Suryavanshi, Byramjee Jeejeebhoy Government Medical College Clinical Trials Unit; M Hughes, Harvard T H Chan School of Public Health; Sarita Shah, Emory University; G Churchyard, University of Witwatersrand; S Swindells, University of Nebraska Medical Center; A Hesseling, Stellenbosch University; A Gupta, GHESKIO Centers
• Journal Title: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
• Volume: Volume 26, Number 10
• Publisher: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | 2022-10-01, Pages 949-955
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.5588/ijtld.21.0760
• Subjects: Health Sciences, Public Health
• Keywords: Science & Technology; Life Sciences & Biomedicine; Infectious Diseases; Respiratory System; tuberculosis; contacts; pediatric; children; prophylaxis; MULTIDRUG-RESISTANT; LATENT TUBERCULOSIS; PREVENTIVE THERAPY; YOUNG-CHILDREN; CONTACTS; MANAGEMENT; HOUSEHOLDS; KNOWLEDGE; ADULT

Abstract

BACKGROUND: Pediatric household contacts (HHCs) of patients with multidrug-resistant TB (MDR-TB) are at high risk of infection and active disease. Evidence of caregiver willingness to give MDR-TB preventive therapy (TPT) to children is limited. METHODS : This was a cross-sectional study of HHCs of patients with MDR-TB to assess caregiver willingness to give TPT to children aged ,13 years. RESULT S : Of 743 adult and adolescent HHCs, 299 reported caring for children aged ,13 years of age. The median caregiver age was 35 years (IQR 27-48); 75% were women. Among caregivers, 89% were willing to give children MDR TPT. In unadjusted analyses, increased willingness was associated with TB-related knowledge (OR 5.1, 95% CI 2.3-11.3), belief that one can die of MDR-TB (OR 5.2, 95% CI 1.2-23.4), concern for MDR-TB transmission to child (OR 4.5, 95% CI 1.6-12.4), confidence in properly taking TPT (OR 4.5, 95% CI 1.6-12.6), comfort telling family about TPT (OR 5.5, 95% CI 2.1-14.3), and willingness to take TPT oneself (OR 35.1, 95% CI 11.0-112.8). CONCLUS IONS : A high percentage of caregivers living with MDR- or rifampicin-resistant TB patients were willing to give children a hypothetical MDRTPT. These results provide important evidence for the potential uptake of effective MDR TPT when implemented.