THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets

• Authors: JL Sharman, University of Edinburgh; Stephen PH Alexander, University of Nottingham; Eamonn Kelly, University of Bristol; Alistair Mathie, University of Suffolk; John A Peters, University of Dundee; Emma L Veale, University of Greenwich; Jane F Armstrong, University of Edinburgh; Elena Faccenda, University of Edinburgh; Simon D Harding, University of Edinburgh; Adam J Pawson, University of Edinburgh; Christopher Southan, University of Edinburgh; Peter O Buneman, University of Edinburgh; John A Cidlowski, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina; Arthur Christopoulos, Monash University; Anthony P Davenport, University of Cambridge; Doriano Fabbro, PIQUR Therapeutics; Michael Spedding, Spedding Research Solutions SARL, Le Vésinet 78110 France; Jörg Striessnig, University of Innsbruck; Jamie A Davies, University of Edinburgh; Katelin E Ahlers-Dannen, University of Iowa; Mohammed Alqinyah, University of Georgia; Thiruma Arumugam, Natl Univ Singapore; Christopher Bodle, University of Pittsburgh; Josephine B Dagner, University of Georgia; Bandana Chakravarti, University of Iowa; Shreoshi P Choudhuri, University of Texas Southwestern Medical Center; Kirk M Druey, National Institute of Health, Bethesda; Rory A Fisher, University of Iowa; Kyle J Gerber, Tetracore Inc; John Hepler, Emory University; Shelley B Hooks, University of Georgia; Havish S Kantheti, University of Texas Southwestern; Behirda Karaj, University of Michigan; Somayeh Layeghi-Ghalehsoukhteh, Cobel Darou; Jae-Kyung Lee, University of Georgia; Zili Luo, University of Iowa; Kirill Martemyanov, Scripps Research Institute; Luke D Mascarenhas, University of Texas Southwestern; Harrison McNabb, Purdue University; Carolina Montañez‐Miranda, Emory University; Osita Ogujiofor, University of Texas Southwestern; Hoa Phan, University of Michigan; David L Roman, University of Iowa; Vincent Shaw, Michigan State University; Benita Sjogren, Purdue University; Christopher Sobey, La Trobe University; Mackenzie M Spicer, University of Iowa; Katherine E Squires, Emory University; Laurie Sutton, University of Maryland, Jupiter; Menbere Wendimu, University of Georgia; Thomas Wilkie, University of Texas Southwestern; Keqiang Xie, Scripps Research Institute; Qian Zhang, Purdue University; Yalda Zolghadri, University of Texas Southwestern
• Journal Title: BRITISH JOURNAL OF PHARMACOLOGY
• Volume: Volume 178, Number S1
• Publisher: WILEY | 2021-10-01, Pages S1-S26
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1111/bph.15537
• Subjects: Health Sciences, Pharmacology; Health Sciences, Pharmacy
• Keywords: Science & Technology; Life Sciences & Biomedicine; Pharmacology & Pharmacy

Abstract

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15537. In addition to this overview, in which are identified ‘Other protein targets’ which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.