The association between long-term exposure to ambient fine particulate matter and glaucoma: A nation-wide epidemiological study among Chinese adults

• Authors: Xueli Yang, Tianjin Medical University; Ze Yang, Tianjin Medical University; Yuanyuan Liu, Tianjin Medical University General Hospital; Xi Chen, Tianjin Medical University; Baoqun Yao, Tianjin Med Univ Gen Hosp; Fengchao Liang, Southern University of Science & Technology; Anqi Shan, Tianjin Medical University; Fangchao Liu, Chinese Academy of Medical Sciences; Song Chen, Tianjin Medical University General Hospital; Xiaochang Yan, Peking University; Jianfeng Huang, Chinese Academy of Medical Sciences; Shaoye Bo, China Fdn Disabled Persons; Yang Liu, Emory University; Naijun Tang, Tianjin Medical University; Dongfeng Gu, Southern University of Science and Technology; Hua Yan, Tianjin Medical University General Hospital
• Journal Title: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
• Volume: Volume 238
• Publisher: ELSEVIER GMBH | 2021-10-08, Pages 113858-113858
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.ijheh.2021.113858
• Subjects: Health Sciences, Medicine and Surgery; Health Sciences, Epidemiology
• Keywords: Science & Technology; Life Sciences & Biomedicine; Public, Environmental & Occupational Health; Infectious Diseases; PM2.5; Eye; Satellite-based model; AIR-POLLUTION; AQUEOUS-HUMOR; PREVALENCE; BURDEN; CYTOKINES; DISEASE

Abstract

Background: A growing body of evidence has confirmed the association between fine particulate matter (PM2.5) and ocular diseases, but little is known on the effect of long-term PM2.5 exposure on glaucoma. Methods: A national cross-sectional study of the Rural Epidemiology for Glaucoma was conducted in 10 provinces of China, and 33,701 adults aged 40 years or more were included. A satellite-based model at 1-km resolution level was used to estimate PM2.5 concentrations which were assigned to each participant according to geocoded home addresses. Logistic regression model was performed to investigate associations of long-term PM2.5 exposure with glaucoma and its subtypes. Results: Estimated PM2.5 concentrations ranged from 28.0 to 96.4 μg/m3. For each 10 μg/m3 increment in PM2.5, the adjusted odds ratios (ORs) were 1.07 (95% CI: 1.00–1.15) and 1.14 (95% CI: 1.02–1.26) for glaucoma and primary angle-closure glaucoma (PACG), respectively. A positive but non-significant association (OR = 1.05, 95% CI: 0.92–1.18) was detected between long-term exposure to PM2.5 and odds of primary open-angle glaucoma. The middle aged residents and non-smokers were more sensitive to the adverse effects of PM2.5. Conclusions: Long-term PM2.5 exposure was associated with glaucoma and PACG in Chinese adults, which provided new insights on adverse ophthalmic effect of PM2.5.