Understanding Aspects of Aluminum Exposure in Alzheimer's Disease Development

• Authors: Ramesh Kandimalla, Emory University; Jayalakshmi Vallamkondu, National Institute of Technology; Edwin B Corgiat, Emory University; Kiran Dip Gill, Post Graduate Institute of Medical Education and Research
• Journal Title: BRAIN PATHOLOGY
• Volume: Volume 26, Number 2
• Publisher: Wiley | 2016-03-01, Pages 139-154
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1111/bpa.12333
• Subjects: Chemistry, Biochemistry; Health Sciences, Oncology
• Keywords: aluminum; Alzheimer's disease; amyloid‐β protein; neurofibrillary tangles

Abstract

Aluminum is a ubiquitously abundant nonessential element. Aluminum has been associated with neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis, and dialysis encephalopathy. Many continue to regard aluminum as controversial although increasing evidence supports the implications of aluminum in the pathogenesis of AD. Aluminum causes the accumulation of tau protein and Aβ protein in the brain of experimental animals. Aluminum induces neuronal apoptosis in vivo and in vitro, either by endoplasmic stress from the unfolded protein response, by mitochondrial dysfunction, or a combination of them. Some, people who are exposed chronically to aluminum, either from through water and/or food, have not shown any AD pathology, apparently because their gastrointestinal barrier is more effective. This article is written keeping in mind mechanisms of action of aluminum neurotoxicity with respect to AD.