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Author Notes:

Jessica Shantha, MD, Assistant Professor of Ophthalmology, Uveitis and Medical Retina, Department of Ophthalmology, Emory University School of Medicine, 1365B Clifton Road NE, Atlanta, GA 30322, Tel: +1 404 778 2020, Fax: +1 404 778 4380. Email: jshanth@emory.edu

Steven Yeh, MD, M. Louise Simpson Associate Professor of Ophthalmology, Uveitis and Vitreoretinal Surgery, Emory University School of Medicine, Faculty Fellow, Emory Global Health Institute. Email: steven.yeh@emory.edu

Subject:

Research Funding:

This project was supported by unrestricted departmental grant from Research to Prevent Blindness, Inc. to the Emory Eye Center, Emory University School of Medicine, National Eye Institute/ National Institutes of Health core grant P30-EY06360 (Department of Ophthalmology, Emory University School of Medicine), National Eye Institute of the National Institutes of Health under award number K23 EY030158 (Shantha) and R01 EY029594 (Yeh). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

Funding support is also provided by the Macula Society, Bayer Global Ophthalmology Awards Program, the Association for Research in Vision and Ophthalmology Mallinckrodt Foundation Young Investigator Award (Yeh), Santen, Inc, and the Sitaraman Family Foundation.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Ophthalmology
  • VIRUS

Posterior Segment Ophthalmic Manifestations in Ebola Survivors, Sierra Leone

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Journal Title:

OPHTHALMOLOGY

Volume:

Volume 128, Number 9

Publisher:

, Pages 1371-1373

Type of Work:

Article | Post-print: After Peer Review

Abstract:

The largest Ebola virus disease (EVD) outbreak occurred from 2013–2016 in West Africa, leading to over 28,600 cases and 11,300 deaths and resulted in the largest cohort of EVD survivors to date.1 Another recent outbreak in Democratic Republic of the Congo (DRC) has resulted in 3,481 cases with over 1,170 survivors since August 2018.2 In studies of large EVD survivor cohorts, uveitis is the most common ocular manifestation with a 13–34% reported prevalence.3,4 Cataract, with or without uveitis, is the second most common finding and has been reported in 10% of EVD survivors.3,4 The Ebola Virus Persistence in Ocular Tissues (EVICT) study was a cross-sectional study which supported the safety of cataract surgery in EVD survivors5, but may not be generalizable to vitreoretinal surgery. Posterior segment findings in EVD survivors have been described primarily in relationship to uveitis and include vitritis, chorioretinitis and chorioretinal scarring.3,6 The prevalence of posterior segment findings in EVD survivors, particularly those that may require surgical intervention, is of particular interest given the risk of Ebola virus (EBOV) persistence in ocular tissues and fluids.7

Copyright information:

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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