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Author Notes:

Seyma Katrinli, Email: seyma.katrunli@emory.edu

SK conceived the idea, designed the review structure, and wrote the manuscript. NCSO contributed to sections on HPA axis and ANS. JCF contributed to sections on neuroimaging and treatment, and reviewed and edited other sections of the paper. VM contributed to sections on immune biomarkers, other drivers of inflammation in PTSD, and treatment, and reviewed and edited other sections of the paper. AKS conceptualized the paper and its organization, comprehensively reviewed all sections, and provided critical edits and revisions on all drafts.

This work was funded by grants from the National Institute of Mental Health R01MH108826 (AKS) and MH115174 (VM). Figures were created with BioRender.com.

The authors declare no competing interests.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Psychiatry
  • ANTERIOR CINGULATE FUNCTION
  • INTERFERON-ALPHA THERAPY
  • QUALITY-OF-LIFE
  • DOUBLE-BLIND
  • FEAR EXTINCTION
  • HEPATITIS-C
  • INFLAMMATORY CYTOKINES
  • HIPPOCAMPAL VOLUME
  • AMYGDALA ACTIVITY
  • NEURAL REGULATION

The role of the immune system in posttraumatic stress disorder

Tools:

Journal Title:

TRANSLATIONAL PSYCHIATRY

Volume:

Volume 12, Number 1

Publisher:

, Pages 313-313

Type of Work:

Article | Final Publisher PDF

Abstract:

Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to traumatic stress. In addition to well-defined psychological and behavioral symptoms, some individuals with PTSD also exhibit elevated concentrations of inflammatory markers, including C-reactive protein, interleukin-6, and tumor necrosis factor-α. Moreover, PTSD is often co-morbid with immune-related conditions, such as cardiometabolic and autoimmune disorders. Numerous factors, including lifetime trauma burden, biological sex, genetic background, metabolic conditions, and gut microbiota, may contribute to inflammation in PTSD. Importantly, inflammation can influence neural circuits and neurotransmitter signaling in regions of the brain relevant to fear, anxiety, and emotion regulation. Given the link between PTSD and the immune system, current studies are underway to evaluate the efficacy of anti-inflammatory treatments in those with PTSD. Understanding the complex interactions between PTSD and the immune system is essential for future discovery of diagnostic and therapeutic tools.

Copyright information:

© The Author(s) 2022

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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