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Rosemary D. Higgins, MD, Associate Dean for Research, Interim Chair, Rehabilitation Sciences, Professor, Department of Global and Community Health, College of Health and Human Services, George Mason University, 4400 University Drive 2G7, Peterson Family Health Science Hall, Room 5415, Fairfax, Virginia 22030, 703-993-1952. Email: rhiggin@gmu.edu
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Ira-Adams Chapman died following writing the manuscript. The study team appreciates her efforts in leading the follow up study, data analysis and completion of the manuscript. She is a very special person and will be missed by all of the team. Mina Chung, MD, was the research ophthalmologist at the University of Rochester and conducted primary outcome examinations for study participants recruited at this center. Dr. Chung provided important contributions to the study concept and design and she performed ophthalmologic evaluations on the 63 infants enrolled at this site. Dr. Chung died prior to preparation of the final manuscript. The study team which like to extend a special acknowledgement of her efforts on this project. The National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) through the Neonatal Research Network, and the National Eye Institute (NEI) provided grant support for the Inositol Trial. While NICHD staff had input into the study design, conduct, analysis, and manuscript drafting, the comments and views of the authors do not necessarily represent the views of NICHD, NEI, the National Institutes of Health, the Department of Health and Human Services, or the U.S. Government. Participating NRN sites collected data and transmitted it to RTI International, the data coordinating center (DCC) for the network, which stored, managed and analyzed the data for this study. On behalf of the NRN, RTI International had full access to all of the data in the study, and with the NRN Center Principal Investigators, takes responsibility for the integrity of the data and accuracy of the data analysis. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study. The following investigators, in addition to those listed as authors, participated in this study: NRN Steering Committee Chair: Richard A. Polin, MD, Division of Neonatology, College of Physicians and Surgeons, Columbia University, (2011-present). Alpert Medical School of Brown University and Women & Infants Hospital of Rhode Island (UG1 HD27904) – Abbot R. Laptook, MD; Martin Keszler, MD; Elisabeth C. McGowan, MD; Angelita M. Hensman, PhD RNC-NIC; Barbara Alksninis, PNP; Mary Lenore Keszler, MD; Andrea M. Knoll; Theresa M. Leach, MEd Emilee Little, RN BSN; Elisabeth C. McGowan, MD; Michael R. Muller, PharmD; Elisa Vieira, RN BSN; Victoria E. Watson, MS CAS. Case Western Reserve University, Rainbow Babies & Children’s Hospital (UG1 HD21364) – Michele C. Walsh, MD MS; Anna Maria Hibbs, MD MSCE; Nancy S. Newman, BA RN; Michael Banchy, RPH; Monika Bhola, MD; Jeffrey L. Blumer, MD; Allison H. Payne, MD MS; Bonnie S. Siner, RN; Elizabeth Ross, MS; Eileen K. Stork, MD; H. Gerry Taylor, PhD; Gulgun Yalcinkaya, MD; Arlene Zadell, RN. Children’s Mercy Hospital, University of Missouri Kansas City School of Medicine (UG1 HD68284) – William E. Truog, MD; Eugenia K. Pallotto, MD MSCE; Prabhu S. Parimi, MD; Cheri Gauldin, RN BSN CCRC; Lisa Gaetano, MSN RN; Anne M. Holmes, RN MSN MBA-HCM CCRC; Kathy Johnson RN, CCRC; Allison Knutson, BSN RNC-NIC. Cincinnati Children’s Hospital Medical Center, University of Cincinnati Medical Center, and Good Samaritan Hospital (UG1 HD27853, UL1 TR77) – Kurt Schibler, MD; Cathy Grisby, BSN CCRC; Patricia Cobb, MS; Teresa L. Gratton, PA; Kristin Kirker, CRC; Stacey Tepe, BS; Sandra Wuertz, RN-BSN CCRP CLC; Kimberly Yolton, PhD. Duke University School of Medicine, University Hospital, University of North Carolina, Duke Regional Hospital, and WakeMed Health and Hospitals (UG1 HD40492, UL1 TR1117) – Ronald N. Goldberg, MD; Joanne Finkle, RN JD; Kimberley A. Fisher, PhD FNP-BC IBCLC; William F. Malcolm, MD; Patricia L. Ashley, MD PHD; Deesha Mago-Shah, MD; Chi Dang-Hornik, PharmD BCPS; Sharon F. Freedman, MD; Kathryn E. Gustafson, PhD; Mary Miller-Bell, PharmD RPh; Sasapin Grace Prakalapakorn, MD MPH; Matthew M. Laughon, MD MPH; Carl L. Bose, MD; Janice Bernhardt, MS RN; Cindy Clark, RN; Diane D. Warner, MD MPH; Michael T. O’Shea, MD MPH; Janice Wereszczak CPNP-AC/PC; Jennifer Talbert, MS RN; Stephen D. Kicklighter, MD; Sofia Aliaga, MD, MPH; Jeffery Board, MD; Kevin Gertsch, MD; Jerry Magolan, MD; Linda Manor, RPh; Jan Niklas Ulrich, MD; Ginger Rhodes-Ryan, ARNP MSN NNP-BC; Donna White, BSN, RN-BC BSN; Alexandra Bentley, MD; Laura Edwards, MD. Emory University, Children’s Healthcare of Atlanta, Grady Memorial Hospital, and Emory University Hospital Midtown (UG1 HD27851, UL1 TR454) – David P. Carlton, MD; Barbara J. Stoll, MD; Ellen C. Hale, RN BS CCRC; Yvonne Loggins, RN; Diane I. Bottcher, RN MSN; Sheena L. Carter, PhD; Colleen Mackie, BS RT; Maureen Mulligan LaRossa, RN; Lynn C. Comerford, NNP; Gloria Smike, PNP MSN; Salathiel Kendrick-Allwood, MD; Angela Leon-Hernandez, MD. Eunice Kennedy Shriver National Institute of Child Health and Human Development – Stephanie Wilson Archer, MA. Indiana University, Riley Hospital for Children and Methodist Hospital at Indiana University Health (UG1 HD27856) – Gregory M. Sokol, MD; Susan Gunn, NNP CCRC; Dianne E. Herron, RN CCRC; Abbey C. Hines, PsyD; Elizabeth Hynes, RNC-NIC; Lu-Ann Papile, MD; Lucy Smiley CCRC. McGovern Medical School at The University of Texas Health Science Center at Houston and Children’s Memorial Hermann Hospital (UG1 HD87229) – Jon E. Tyson, MD MPH; Kathleen A. Kennedy, MD MPH; Amir M. Khan, MD; Andi Duncan, MD, Ricardo Mosquera, MD, MS, Elizabeth Allain, MS; Julie Arldt-McAlister, MSN APRN; Shanti Brown, RCPhT; Allison G. Dempsey, PhD; Elizabeth Eason, MD; Farida El-Ali, RPH; Carmen Garcia, RN BSN; Kartik Kumar, MD; Janice John, CPNP; Patrick M. Jones, MD MA; M. Layne Lillie, RN BSN; Karen Martin, RN; Sara C. Martin, RN; Georgia E. McDavid, RN; Shannon McKee EdS; Hatice Ozsoy, PhD RPh; Shawna Rodgers, RN; Daniel Sperry, RN; Emily K. Stephens, RN BSN; Vu Ta, PharmD; Christine Wong, PharmD; Sharon L. Wright, MT (ASCP). Nationwide Children’s Hospital and The Ohio State University Wexner Medical Center (UG1 HD68278) – Pablo J. Sánchez, MD; Leif D. Nelin, MD; Sudarshan R. Jadcherla, MD; Amanda E. Graf, MD; Patricia Luzader, RN; Christine A. Fortney, PhD RN; Gail E. Besner; Nehal A. Parikh, MD; David L. Rogers, MD; Richard P. Golden, MD; Catherine Olson Jordan, MD. RTI International (U10 HD36790) – Dennis Wallace, PhD; Marie G. Gantz, PhD; Carla M. Bann, PhD; Jeanette O’Donnell Auman, BS; Margaret M. Crawford, BS CCRP; Jenna Gabrio, MPH CCRP; Carolyn M. Petrie Huitema, MS CCRP; James W. Pickett II, BS; Annie M. VonLehmden, BS. Stanford University and Lucile Packard Children’s Hospital (UG1 HD27880, UL1 TR93) – Krisa P. Van Meurs, MD; David K. Stevenson, MD; M. Bethany Ball, BS CCRC; Steven Chinn, PharmD; Melinda S. Proud, RCP; Barbara Bentley, PsychD MSEd; Maria Elena DeAnda, PhD; Anne M. DeBattista, RN PNP PhD; Beth Earhart, PhD; Lynne C. Huffman, MD; Casey E. Krueger, PhD; Ryan Lucash, PhD; Hali E. Weiss, MD. University of Alabama at Birmingham Health System and Children’s Hospital of Alabama (UG1 HD34216) – Waldemar A. Carlo, MD; Namasivayam Ambalavanan, MD; Monica V. Collins, RN BSN MaEd; Shirley S. Cosby, RN BSN; Rebecca J. Quinn, PharmD; Brenda Reed Denson, PharmD; Ann Marie Arciniegas-Bernal, MD; Fred J. Biasini, PhD; Kristen C. Johnston, MSN CRNP; Cryshelle S. Patterson, PhD; Vivien A. Phillips, RN BSN; Sally Whitley, MA OTR-L FAOTA. University of California - Los Angeles, Mattel Children’s Hospital, Santa Monica Hospital, Los Robles Hospital and Medical Center, and Olive View Medical Center (UG1 HD68270) – Uday Devaskar, MD; Meena Garg, MD; Teresa Chanlaw, MPH; Rachel Geller, RN BSN. University of Iowa (UG1 HD53109, UL1 TR442) – Edward F. Bell, MD; Jane E. Brumbaugh, MD; Karen J. Johnson, RN BSN; Jacky R. Walker, RN; Claire A. Goeke, RN; Kristine M. Johnson, BSPharm RPh; Angela Merriss, BA CPhT; Joanna L. Nohr, PharmD BCPS; Susannah Q. Longmuir, MD; Arlene V. Drack, MD; Diane L. Eastman, RN CPNP MA; Scott A. Larson, MD; Kevin R. Gertsch, MD; Vikki P. Bell. University of New Mexico Health Sciences Center (UG1 HD53089, UL1TR41) – Robin K. Ohls, MD; Sandra Sundquist Beauman, MSN RNC; Tara Dupont, MD; Mary Ruffaner Hanson, RN BSN; Carol H, Hartenberger, MPH RN; Elizabeth Kuan, RN BSN; Susan J. Kunkel, PharmD; Jean Lowe, PhD; Nancy A. Morgan, RPh MBA. University of Oulu, and Oulu University Hospital, Oulu, Finland – Mikko K. Hallman, MD. University of Pennsylvania, Hospital of the University of Pennsylvania, Pennsylvania Hospital, and Children’s Hospital of Philadelphia (UG1 HD68244) – Barbara Schmidt, MD MSc; Haresh Kirpalani, MB MSc; Soraya Abbasi, MD; Aasma S. Chaudhary, BS RRT; Toni Mancini, RN BSN CCRC; William V. Anninger, MD; Judy C. Bernbaum, MD; Gil Binenbaum, MD MSCE; Noah Cook, MD; Stefanie L. Davidson, MD; Marsha Gerdes, PhD; Hallam Hurt, MD; Monte D. Mills, MD; Mina Ricciardelli, PharmD; Kenneth Rockwell, Jr., PharmD MS; Jonathan Snyder, RN BSN; Sze Man Yau, RPh. University of Rochester Medical Center, Golisano Children’s Hospital, and the University of Buffalo Women’s and Children’s Hospital of Buffalo (UG1 HD68263, UL1 TR42) – Carl D’Angio, MD; Satyan Lakshminrusimha, MD; Anne Marie Reynolds, MD MPH; Stephen A. Bean, PharmD; Melissa F. Carmen, MD; Patricia R. Chess, MD; Rosemary Jensen; Rajeev S. Ramchandran, MD; Ann Marie Turner, PharmD; Ashley Williams, MS Ed; Michael G. Sacilowski, MAT; Holly Wadkins, MA; Julianne Hunn; Aimee Horan, LPN; Melissa Bowman, RN NP; Michele Hartley-McAndrew, MD; William Zorn, PhD; Osman Farooq, MD; Kelley Yost, PhD; Joan Merzbach, LMSW; Cait Fallone, MA; Kyle Binion, BS; Constance Orme; Premini Sabaratnam, MPH. University of Texas Southwestern Medical Center, Parkland Health & Hospital System, and Children’s Medical Center Dallas (UG1 HD40689) – Myra H. Wyckoff, MD; Luc P. Brion, MD; Diana M. Vasil, RNC-NIC; Sally S. Adams, MS RN CPNP; Christine Cha, PharmD; Juana Cisneros, RN; Maria M. De Leon, BSN RN; Frances Eubanks, BSN RN; Lynda Godowic, PharmD RPh; Laura Grau, RN; Alicia Guzman; Elizabeth Heyne, PsyD PA-C; Lizette E. Lee, RN; Helen C. Lira, PharmD; Azadeh Mozaffari, PharmD RPh; Lara Pavageau, MD; Catherine Twell Boatman, MS CIMI; Reshma Wright, RPh. Wayne State University, Hutzel Women’s Hospital and Children’s Hospital of Michigan (UG1 HD21385) – Seetha Shankaran, MD; Beena G. Sood, MD MS; Rebecca Bara, RN BSN; Prashant Agarwal, MD; Monika Bajaj, MD; Sanjay Chawla, MD; Kirsten Childs, RN BSN; Melissa February, MD; Laura A. Goldston, MA; Mary E. Johnson, RN BSN; Mirjana Lulic-Botica, RPh; Bogdan Panaitescu, MD; Eunice Woldt, RN MSN. Data and Safety Monitoring Committee – Christine A. Gleason, MD, chair, University of Washington; Marilee C. Allen, MD, Johns Hopkins University School of Medicine; Robert J. Boyle, MD, University of Virginia Health System; Traci Clemons, PhD, The EMMES Corporation; Mary E. D’Alton, MD, Columbia Ob/Gyn Midtown; Abhik Das (ex officio), PhD, RTI International; Donald Everett, MA (non-voting member), National Eye Institute; Ralph E. Kauffman, MD, University of Missouri-Kansas City, Medical Research Department at Children’s Mercy Hospital; Menachem Miodovnik, MD, Washington Hospital Center; T. Michael O’Shea, MD MPH, Wake Forest University School of Medicine; Lois Smith, MD, Harvard University Children’s Hospital; Steven J. Weiner, MS, The George Washington University; Marian Willinger (ex officio), PhD, Eunice Kennedy Shriver National Institute of Child Health and Human Development. The BOOST Study ROP Credentialing site, www.boostnz.info/ROP/[boostnz.info, allowed NRN ophthalmologists to use their online system to certify their ROP training.
None of the authors report any commercial, proprietary, or financial interest in any of the products described in this article. NICHD is the sponsor of the study and holds the investigational new drug (IND) application. Abbott Nutrition Division, Abbott Laboratories, Columbus, OH, provided the inositol product. They had no role in the: design of the trial; the analyses, interpretation, or writing of the manuscript; or the decision to submit the manuscript for publication. They provided on-site monitoring to assist in quality assurance of the data collection.
Funded by the National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)( U10 HD36790, UG1 HD27904, UG1 HD21364, UG1 HD68284, UG1 HD27853, UG1 HD40492, UG1 HD27851, UG1 HD27856, UG1 HD87229, UG1 HD68278, UG1 HD27880, UG1 HD34216, UG1 HD68270, UG1 HD53109, UG1 HD53089, UG1 HD68244, UG1 HD68263, UG1 HD40689, UG1 HD21385), the National Eye Institute (via co-funding to NICHD), and the National Center for Advancing Translational Sciences (UL1 TR41, UL1 TR42, UL1 TR77, UL1 TR93, UL1 TR442, UL1 TR454, UL1 TR1117).