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Author Notes:

Zhou Zhu, zhouzhu@hust.edu.cn

Suiqiang Zhu, zhusuiqiang@163.com

SZ and ZZ led the study. XQ performed the data analysis and implemented the methodology. XS, WS, JM, YL, GL, and XZ collected the data. ZZ and XQ prepared the original draft. SZ reviewed and edited the final manuscript. YC touched the language of this article. All authors contributed to the article and approved the submitted version.

We would like to acknowledge all participants of this project and investigators for collecting data. We would like to thank Xiaoyan Song for collecting the data.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Subject:

Research Funding:

This work was financially supported by the National Key R&D Program of China [grant number 2017YFC1310000], the Fundamental Research Funds for the Central Universities [grant number 2018KFYXMPT015], and Hubei Technological Innovation Special Fund [grant number 2019ACA132]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ZZ and SZ had full access to all the data in the study and had final responsibility for the decision to submit for publication.

Keywords:

  • cerebral artery diseases
  • nomogram
  • post-stroke depression
  • prediction
  • stroke

Association of Cerebral Artery Stenosis With Post-stroke Depression at Discharge and 3 Months After Ischemic Stroke Onset

Tools:

Journal Title:

Frontiers in Psychiatry

Volume:

Volume 11

Publisher:

, Pages 585201-585201

Type of Work:

Article | Final Publisher PDF

Abstract:

Background: Post-stroke depression (PSD) is one of the most common complications after stroke, which seriously affects patients' recovery outcome. Although vascular depression has been extensively studied, the relationship between cerebral artery stenosis and PSD has not been clarified so far. Methods: Two hundred ninety-eight patients with ischemic stroke (72 women, 226 men) with computed tomography angiography (CTA) or magnetic resonance angiography (MRA) were included in this study. Cerebral artery stenosis ≥50% was used as the cut-off value. The DSM-V diagnostic criteria of PSD was met and the 17-item Hamilton Rating Scale for Depression (HAMD-17) score over 7 at discharge and 3 months after stroke onset was regarded as the primary outcome. The χ2-test, Mann-Whitney U-test, and t-test were used to check for statistical significance. Results: At discharge, Barthel index (p < 0.001), left middle cerebral artery stenosis (p = 0.019), drinking history (p = 0.048), basilar artery stenosis (p = 0.037) were significantly associated with PSD. At 3 months after ischemic stroke onset, Barthel index (p = 0.011), left middle cerebral artery stenosis (p = 0.012), female gender (p = 0.001) were significantly associated with PSD. Conclusions: The findings demonstrated that left middle cerebral artery and basilar artery stenosis are associated with PSD. It was suggested that cerebral artery stenosis was a risk factor of PSD and should be recognized and intervened early. Registration Number: ChiCTR-ROC-17013993.

Copyright information:

© 2020 Qiu, Miao, Lan, Sun, Chen, Cao, Li, Zhao, Zhu and Zhu.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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