About this item:

41 Views | 24 Downloads

Author Notes:

Dalane W. Kitzman, MD, Kermit Glenn Phillips II Chair in Cardiovascular Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1045, Tel: 336-716-3274, Fax: 336-716-4995. Email: dkitzman@wakehealth.edu

In addition to partial funding for the present study from Novartis (which had no role in study conduct, data analysis, interpretation, or manuscript generation), Dr. KItzman reports the following potential financial conflicts of interest: Consultant for Abbvie, Bayer, Merck, Medtronic, Relypsa, Merck, Corvia Medical, Boehringer-Ingelheim, GSK, and Actavis, current research grant funding from Novartis, Bayer, and GSK, and stock ownership in Gilead Sciences. Dr. Upadhya has received research funding from Novarits and Corvia.

Subject:

Research Funding:

This study was funded, in part, by an investigator-initiated grant from Novartis Pharmaceuticals. However, Novartis had no role in study conduct, data analysis, interpretation, or manuscript generation.

Also funded in part by: NIH R01AG18915 and R01AG045551; The Claude D. Pepper Older Americans Independence Center of Wake Forest University NIH P30AG21332; Clinical and Translational Science Institute of Wake Forest School of Medicine NIH UL1TR001420; and the Kermit G. Phillips II Chair in Cardiovascular Medicine of Wake Forest School of Medicine.

Keywords:

  • Older Patients
  • Heart Failure

The Effect of Aliskiren on Exercise Capacity in Older Patients with Heart Failure and Preserved Ejection Fraction: A Randomized, Placebo-Controlled, Double-Blind Trial

Tools:

Journal Title:

AMERICAN HEART JOURNAL

Volume:

Volume 201

Publisher:

, Pages 164-167

Type of Work:

Article | Post-print: After Peer Review

Abstract:

In older patients (70±7 years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6 months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exercise oxygen consumption (14.9±0.2 ml/kg/min versus 14.4±0.2 ml/kg/min; p=0.10, trend) and ventilatory anaerobic threshold (888±19 m//min versus 841±18ml/min; p=0.08).

Copyright information:

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Export to EndNote